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4.2.1.75: uroporphyrinogen-III synthase

This is an abbreviated version!
For detailed information about uroporphyrinogen-III synthase, go to the full flat file.

Word Map on EC 4.2.1.75

Reaction

Hydroxymethylbilane
=
uroporphyrinogen III
+
H2O

Synonyms

CobA/HemD, Hydroxymethylbilane hydrolyase [cyclizing], hydroxymethylbilane hydrolyase, cyclizing, Isomerase, uroporphyrinogen, Porphobilinogenase, Synthase, uroporphyrinogen III co-, U3S, URO synthase, uro'gen III synthase, URO-synthase, UROIIIS, Uroporphyrinogen III co-synthase, Uroporphyrinogen III cosynthase, Uroporphyrinogen III synthase, Uroporphyrinogen isomerase, Uroporphyrinogen-III cosynthase, Uroporphyrinogen-III cosynthetase, uroporphyrinogen-III-synthase, UROS

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.75 uroporphyrinogen-III synthase

Expression

Expression on EC 4.2.1.75 - uroporphyrinogen-III synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
branchpoint sequence mutation markedly reduces the wild type transcript and enzyme activity
-
the efficiency of Uros gene suppression is developmentally regulated, being most effective in mature seedling leaves compared with newly emergent leaves
-
the hepatic and splenic URO-synthase activities are normal or elevated (1-1.6fold) compared with age and sex-matched feline control activities in the dominantly inherited acute intermittent porphyria lines
-