4.2.1.70: pseudouridylate synthase

This is an abbreviated version!
For detailed information about pseudouridylate synthase, go to the full flat file.

Reaction

Synonyms

16S pseudouridine 516 synthase, 16S pseudouridylate 516 synthase, 5-ribosyluracil 5'-phosphate synthetase, Depressed growth-RATE protein DEG1, IndA, More, ORP protein, Osmoprotectant regulator of PLC, P35 protein, pseudouridine monophosphate synthetase, pseudouridine synthase, pseudouridine synthase I, pseudouridine-5'-phosphate glycosidase, Pseudouridylate synthase, pseudouridylate synthetase, pseudouridylate synthetase I, pseudouridylate synthetase II, pseudouridylic acid synthetase, PSI55 synthase, psi55 tRNA pseudouridine synthase, psiMP synthetase, psisynthetase, psiUMP synthetase, PSUI, PUS, synthase, pseudouridylate, tRNA pseudouridine 55 synthase, TruB, uracil hydrolyase, YeiN

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.70 pseudouridylate synthase

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Results	in table
9218	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
2	Crystallization (Commentary)
2	General Information
4	General Stability
10	Inhibitors
1	Ki Value [mM]
9	KM Value [mM]
2	Localization
6	Metals/Ions
5	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
107	Organism
3	Pathway
37	PDB ID
5	pH Optimum
2	pH Range
9	Purification (Commentary)
1	Reaction
40	Reaction Type
72	Reference
2	Source Tissue
15	Specific Activity [micromol/min/mg]
2	Storage Stability
64	Substrates and Products (Substrate)
3	Subunits
41	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.1.70 - pseudouridylate synthase

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SYSTEMATIC NAME

IUBMB Comments

uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)

The reaction it readily reversible. While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo [5].