4.2.1.54: lactoyl-CoA dehydratase

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For detailed information about lactoyl-CoA dehydratase, go to the full flat file.

Word Map on EC 4.2.1.54

4.2.1.54

propionicum

propionate

acrylate

dehydration

nucleatum

acrylyl-coa

coa-transferase

hydroxylamine

2-hydroxyglutaryl-coa

crotonyl-coa

fermentans

iron-sulfur

acidaminococcus

riboflavin

2-hydroxyacyl-coa

crotonase

mgcl2

chloramphenicol

Reaction

Synonyms

(R)-lactyl-CoA dehydratase, acrylyl coenzyme A hydratase, dehydratase, lactoyl-coenzyme A, lactoyl coenzyme A dehydratase, lactoyl-CoA dehydratase subunit alpha, lactyl CoA dehydratase, lactyl-CoA dehydrase, lactyl-CoA dehydratase, lactyl-coenzyme A dehydrase, LCD, lcdA

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.54 lactoyl-CoA dehydratase

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Results	in table
5	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
3	Cofactor
1	General Stability
2	Metals/Ions
3	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
35	Organism
1	Oxidation Stability
7	Pathway
2	pH Optimum
2	Purification (Commentary)
3	Reaction
2	Reaction Type
29	Reference
5	Specific Activity [micromol/min/mg]
2	Storage Stability
34	Substrates and Products (Substrate)
1	Subunits
52	Synonyms
1	Systematic Name

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Reference on EC 4.2.1.54 - lactoyl-CoA dehydratase

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33926

Baldwin, R.L.; Wood, W.A.

Lactyl-CoA dehydrase

Methods Enzymol.

683-685

1966

Megasphaera elsdenii

33927

Baldwin, R.L.; Wood, W.A.; Emery, R.S.

Lactate metabolism by Peptostreptococcus elsdenii: evidence for lactyl coenzyme A dehydrase

Biochim. Biophys. Acta

202-213

1965

Megasphaera elsdenii

14292829

33928

Schweiger, G.; Buckel, W.

On the dehydration of (R)-lactate in the fermentation of alanine to propionate by Clostridium propionicum

FEBS Lett.

171

79-84

1984

Anaerotignum propionicum

6586495

33929

Kuchta, R.D.; Hanson, G.R.; Holmquist, B.; Abeles, R.H.

Fe-S centers in lactyl-CoA dehydratase

Biochemistry

7301-7307

1986

Anaerotignum propionicum

3026450

33930

Hofmeister, A.E.M.; Buckel.W.

(R)-lactyl-CoA dehydratase from Clostridium propionicum. Stereochemistry of the dehydration of (R)-2-hydroxybutyryl-CoA to crotonyl-CoA

Eur. J. Biochem.

206

547-552

1992

Anaerotignum propionicum

1597194

33931

Brunelle, S.L.; Abeles, R.H.

The stereochemistry of hydration of acrylyl-CoA catalyzed by lactyl-CoA dehydratase

Bioorg. Chem.

118-126

1993

Anaerotignum propionicum

718680

Kandasamy, V.; Vaidyanathan, H.; Djurdjevic, I.; Jayamani, E.; Ramachandran, K.; Buckel, W.; Jayaraman, G.; Ramalingam, S.

Engineering Escherichia coli with acrylate pathway genes for propionic acid synthesis and its impact on mixed-acid fermentation

Appl. Microbiol. Biotechnol.

1191-1200

2013

Anaerotignum propionicum, Anaerotignum propionicum DSM 1682

22810300

729862

Reichardt, N.; Duncan, S.H.; Young, P.; Belenguer, A.; McWilliam Leitch, C.; Scott, K.P.; Flint, H.J.; Louis, P.

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

ISME J.

1323-1335

2014

[Clostridium] symbiosum, Clostridium botulinum, Clostridioides difficile, Clostridium novyi, Clostridium sp., Megasphaera elsdenii, Coprococcus catus, butyrate-producing bacterium SS3/4, Enterocloster asparagiformis, Anaerotignum propionicum (G3KIM4), Clostridium novyi NT, Coprococcus catus GD/7, [Clostridium] symbiosum WAL-14163, Clostridioides difficile 630, Enterocloster asparagiformis DSM 15981, Anaerotignum propionicum DSM 1682 (G3KIM4), Clostridium sp. M62/1, Clostridium sp. MSTE9 (cluster XIVb), Megasphaera elsdenii LC1 DSM 20460T, Clostridium botulinum C Eklund, Clostridium botulinum A2

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