4.2.1.36: homoaconitate hydratase
This is an abbreviated version!
For detailed information about homoaconitate hydratase, go to the full flat file.
Word Map on EC 4.2.1.36
-
4.2.1.36
-
alpha-aminoadipate
-
homocitrate
-
isopropylmalate
-
auxotrophy
-
homoisocitrate
-
l-lysine
-
lys4
-
jannaschii
-
saccharopine
-
methanocaldococcus
-
synthesis
-
medicine
- 4.2.1.36
- alpha-aminoadipate
- homocitrate
- isopropylmalate
-
auxotrophy
- homoisocitrate
- l-lysine
- lys4
- jannaschii
- saccharopine
-
methanocaldococcus
- synthesis
- medicine
Reaction
Synonyms
2-hydroxy-3-carboxyadipate hydro-lyase, cis-Homoaconitase, HACN, HACNMj, Homoaconitase, Homoaconitate hydratase, Hydratase, homoaconitate, leuC, LYS4, lysF, MJ0499, MJ1271
ECTree
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Systematic Name
Systematic Name on EC 4.2.1.36 - homoaconitate hydratase
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(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]
Requires a [4Fe-4S] cluster for activity. The enzyme from the hyperthermophilic eubacterium Thermus thermophilus can catalyse the reaction shown above but cannot catalyse the previously described reaction, i.e. formation of (R)-homocitrate by hydration of cis-homoaconitate. The enzyme responsible for the conversion of cis-homoaconitate into (R)-homocitrate in T. thermophilus is unknown at present but the reaction can be catalysed in vitro using aconitate hydratase from pig (EC 4.2.1.3) [2].