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4.2.1.36: homoaconitate hydratase

This is an abbreviated version!
For detailed information about homoaconitate hydratase, go to the full flat file.

Word Map on EC 4.2.1.36

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
=
(Z)-but-1-ene-1,2,4-tricarboxylate
+
H2O

Synonyms

2-hydroxy-3-carboxyadipate hydro-lyase, cis-Homoaconitase, HACN, HACNMj, Homoaconitase, Homoaconitate hydratase, Hydratase, homoaconitate, leuC, LYS4, lysF, MJ0499, MJ1271

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.36 homoaconitate hydratase

Substrates Products

Substrates Products on EC 4.2.1.36 - homoaconitate hydratase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O
show the reaction diagram
(R)-homocitrate
?
show the reaction diagram
-
-
-
-
?
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
show the reaction diagram
-
i.e. cis-homoaconitate, three different stereoisomeric substrate types, cis-homo1-aconitate, cis-homo2-aconitate, and cis-homo3-aconitate, in the reaction, overview
i.e. homoisocitrate, Arg26 of MJ1271 plays a key role in homoaconitate substrate recognition, while discriminating against the hydrophobic methyl or isopropyl gamma-chains of citraconate and 3-isopropylmalate. Catalytic Ser67 and Arg69 residues in the IMPI small subunit MJ1277 model are equivalent to Ser65 and Arg67 in MJ1271, but residues Val28-Tyr29 replace the polar Arg26-Thr27 residues in the flexible loop region between alpha2 and alpha3
-
r
(Z)-but-1-ene-1,2,4-tricarboxylic acid
?
show the reaction diagram
-
-
-
-
?
(Z)-hex-1-ene-1,2,6-tricarboxylate
?
show the reaction diagram
-
-
-
-
?
(Z)-pent-1-ene-1,2,5-tricarboxylate
?
show the reaction diagram
-
-
-
-
?
2-Hydroxy-3-carboxyadipate
?
show the reaction diagram
2-hydroxybutane-1,2,4-tricarboxylate
but-1-ene-1,2,4-tricarboxylate + H2O
show the reaction diagram
cis-homoaconitate
homoisocitrate + H2O
show the reaction diagram
cis-homoaconitate + H2O
(2R,3S)-homoisocitrate
show the reaction diagram
-
-
-
-
?
additional information
?
-