4.2.1.36: homoaconitate hydratase
This is an abbreviated version!
For detailed information about homoaconitate hydratase, go to the full flat file.
Word Map on EC 4.2.1.36
-
4.2.1.36
-
alpha-aminoadipate
-
homocitrate
-
isopropylmalate
-
auxotrophy
-
homoisocitrate
-
l-lysine
-
lys4
-
jannaschii
-
saccharopine
-
methanocaldococcus
-
synthesis
-
medicine
- 4.2.1.36
- alpha-aminoadipate
- homocitrate
- isopropylmalate
-
auxotrophy
- homoisocitrate
- l-lysine
- lys4
- jannaschii
- saccharopine
-
methanocaldococcus
- synthesis
- medicine
Reaction
Synonyms
2-hydroxy-3-carboxyadipate hydro-lyase, cis-Homoaconitase, HACN, HACNMj, Homoaconitase, Homoaconitate hydratase, Hydratase, homoaconitate, leuC, LYS4, lysF, MJ0499, MJ1271
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Reference
Reference on EC 4.2.1.36 - homoaconitate hydratase
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Broquist, H.P.
cis-Homoaconitase
Methods Enzymol.
17B
114-118
1971
Saccharomyces cerevisiae
-
Betterton, H.; Fjellstedt, T.; Matsuda, M.; Ogur, M.; Tate, R.
Localization of the homocitrate pathway
Biochim. Biophys. Acta
170
459-461
1968
Saccharomyces cerevisiae
Strassman, M.; Ceci, L.N.
Enzymatic formation of cis-homoaconitic acid, an intermediate in lysine biosynthesis in yeast
J. Biol. Chem.
241
5401-5407
1966
Saccharomyces cerevisiae
Irvin, S.D.; Bhattacharjee, J.K.
A unique fungal lysine biosynthesis enzyme shares a common ancestor with tricarboxylic acid cycle and leucine biosynthetic enzymes found in diverse organisms
J. Mol. Evol.
46
401-408
1998
Aspergillus nidulans, Saccharomyces cerevisiae, Methanocaldococcus jannaschii
Weidner, G.; Steffan, B.; Brakhage, A.A.
The Aspergillus nidulans lysF gene encodes homoaconitase, an enzyme involved in the fungus-specific lysine pathway
Mol. Gen. Genet.
255
237-247
1997
Aspergillus nidulans
Ye, Z.H.; Bhattacharjee, J.K.
Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe
J. Bacteriol.
170
5968-5970
1988
Schizosaccharomyces pombe
Liebmann, B.; Muhleisen, T.W.; Muller, M.; Hecht, M.; Weidner, G.; Braun, A.; Brock, M.; Brakhage, A.A.
Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis
Arch. Microbiol.
181
378-383
2004
Aspergillus fumigatus
Lombo, T.; Takaya, N.; Miyazaki, J.; Gotoh, K.; Nishiyama, M.; Kosuge, T.; Nakamura, A.; Hoshino, T.
Functional analysis of the small subunit of the putative homoaconitase from Pyrococcus horikoshii in the Thermus lysine biosynthetic pathway
FEMS Microbiol. Lett.
233
315-324
2004
Pyrococcus horikoshii
Jia, Y.; Tomita, T.; Yamauchi, K.; Nishiyama, M.; Palmer, D.R.
Kinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilus
Biochem. J.
396
479-485
2006
Thermus thermophilus
Drevland, R.M.; Waheed, A.; Graham, D.E.
Enzymology and evolution of the pyruvate pathway to 2-oxobutyrate in Methanocaldococcus jannaschii
J. Bacteriol.
189
4391-4400
2007
Methanocaldococcus jannaschii
Jeyakanthan, J.; Drevland, R.M.; Gayathri, D.R.; Velmurugan, D.; Shinkai, A.; Kuramitsu, S.; Yokoyama, S.; Graham, D.E.
Substrate specificity determinants of the methanogen homoaconitase enzyme: structure and function of the small subunit
Biochemistry
49
2687-2696
2010
Methanocaldococcus jannaschii
Teves, F.; Lamas-Maceiras, M.; Garcia-Estrada, C.; Casqueiro, J.; Naranjo, L.; Ullan, R.V.; Scervino, J.M.; Wu, X.; Velasco-Conde, T.; Martin, J.F.
Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: homocitrate as a sensor of lysine-pathway distress
Microbiology
155
3881-3892
2009
Aspergillus nidulans (Q92412), Aspergillus nidulans, Penicillium chrysogenum (B1P2N4), Penicillium chrysogenum
Lee, E.H.; Lee, K.; Hwang, K.Y.
Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii
Acta Crystallogr. Sect. D
70
922-931
2014
Methanocaldococcus jannaschii (P81291), Methanocaldococcus jannaschii
Milewska, M.; Prokop, M.; Gabriel, I.; MilewskiWojciechowski, M.; Milewski, S.
Antifungal activity of homoaconitate and homoisocitrate analogs
Molecules
17
14022-14036
2012
Candida albicans
Wang, J.; Wu, Y.; Sun, X.; Yuan, Q.; Yan, Y.
De novo biosynthesis of glutarate via alpha-keto acid carbon chain extension and decarboxylation pathway in Escherichia coli
ACS Synth. Biol.
6
1922-1930
2017
Saccharomyces cerevisiae (P49367), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P49367)
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