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4.2.1.36: homoaconitate hydratase

This is an abbreviated version!
For detailed information about homoaconitate hydratase, go to the full flat file.

Word Map on EC 4.2.1.36

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
=
(Z)-but-1-ene-1,2,4-tricarboxylate
 +
H2O

Synonyms

2-hydroxy-3-carboxyadipate hydro-lyase, cis-Homoaconitase, HACN, HACNMj, Homoaconitase, Homoaconitate hydratase, Hydratase, homoaconitate, leuC, LYS4, lysF, MJ0499, MJ1271

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.36 homoaconitate hydratase

Expression

Expression on EC 4.2.1.36 - homoaconitate hydratase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
no LYS4 transcripts are observed in cells grown in low-iron medium, whereas abundant transcripts are observed in the cells grown in the high-iron medium. These results confirm the regulation of LYS4 by iron availability and indicate that the LYS4 gene is mainly transcribed when sufficient iron is present in the environment. Iron availability influences both transcript and protein levels for Lys4
-
transcription factors HAP3 or HAPX negatively regulate expression of the gene, but only in iron-depleted conditions. The transcription factors do not influence LYS4 transcript levels upon iron repletion
-
transcription of the lys3 gene shows a 3fold increase in the transcript level of this gene in strain L2 as compared with the parental strain Wis 54-1255