4.2.1.35: (R)-2-methylmalate dehydratase

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For detailed information about (R)-2-methylmalate dehydratase, go to the full flat file.

Reaction

Synonyms

Citraconase, Citraconate hydratase, Citramalate hydro-lyase, Hydratase, citraconate

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.35 (R)-2-methylmalate dehydratase

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Results	in table
4	Activating Compound
157	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
7	Inhibitors
1	KM Value [mM]
1	Metals/Ions
2	Natural Substrates/ Products (Substrates)
6	Organism
7	Pathway
9	PDB ID
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
1	Specific Activity [micromol/min/mg]
7	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name

Inhibitors

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Inhibitors on EC 4.2.1.35 - (R)-2-methylmalate dehydratase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2,2'-dipyridyl

Pseudomonas sp.

-

1 mM, 99% inhibition in absence of GSH, 74% inhibition in presence of 0.5 mM GSH

5671

Cu2+

Pseudomonas sp.

-

-

5671

diphosphate

Pseudomonas sp.

-

1 mM, 99% inhibition in absence of GSH, 74% inhibition in presence of 0.5 mM GSH

5671

EDTA

Pseudomonas sp.

-

1 mM, 99% inhibition in absence of GSH, 74% inhibition in presence of 0.5 mM GSH

5671

Hg2+

Pseudomonas sp.

-

-

5671

iodoacetate

Pseudomonas sp.

-

-

5671

PCMB

Pseudomonas sp.

-

-

5671