4.2.1.34: (S)-2-methylmalate dehydratase
This is an abbreviated version!
For detailed information about (S)-2-methylmalate dehydratase, go to the full flat file.
Reaction
Synonyms
(+)-Citramalic hydro-lyase, Bxe_A3136, Dehydratase, citramalate, FumA, fumarase A, fumarase/mesaconase, FumD, Hydratase, mesaconate, Mesaconase, Mesaconase, mesaconate, mesaconase/fumarase, Mesaconate hydratase
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Substrates Products
Substrates Products on EC 4.2.1.34 - (S)-2-methylmalate dehydratase
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REACTION DIAGRAM
(L)-citramalate
mesaconate + H2O
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enzyme is specific to (L)-citramalate, the rate of dehydration of (D)-citramalate is below 10% of that for the (L) isomer
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r
(L)-citramalate
mesaconate + H2O
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enzyme is specific to (L)-citramalate, the rate of dehydration of (D)-citramalate is below 10% of that for the (L) isomer
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r
(S)-citramalate
mesaconate + H2O
the catalytic efficiency of FumA with (S)-citramalate/mesaconate is about 4% of that with fumarate or (S)-malate
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-
r
(S)-citramalate
mesaconate + H2O
Escherichia coli W3110 / K-12
the catalytic efficiency of FumA with (S)-citramalate/mesaconate is about 4% of that with fumarate or (S)-malate
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r
(S)-malate
fumarate + H2O
the catalytic efficiency of FumA with (S)-citramalate/mesaconate is about 4% of that with fumarate or (S)-malate
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r
(S)-malate
fumarate + H2O
Escherichia coli W3110 / K-12
the catalytic efficiency of FumA with (S)-citramalate/mesaconate is about 4% of that with fumarate or (S)-malate
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r
(S)-malate
heterologously produced FumD is a promiscuous mesaconase/fumarase with a 2- to 3-fold preference for mesaconate over fumarate
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r
fumarate + H2O
(S)-malate
heterologously produced FumD is a promiscuous mesaconase/fumarase with a 2- to 3fold preference for mesaconate over fumarate
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r
fumarate + H2O
(S)-malate
the catalytic efficiency of FumA with (S)-citramalate/mesaconate is about 4% of that with fumarate or (S)-malate
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r
fumarate + H2O
(S)-malate
Escherichia coli ATCC 700728 / O157:H7
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heterologously produced FumD is a promiscuous mesaconase/fumarase with a 2- to 3-fold preference for mesaconate over fumarate
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r
fumarate + H2O
(S)-malate
Escherichia coli W3110 / K-12
the catalytic efficiency of FumA with (S)-citramalate/mesaconate is about 4% of that with fumarate or (S)-malate
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-
r
fumarate + H2O
(S)-malate
Escherichia coli W3110 / K-12
heterologously produced FumD is a promiscuous mesaconase/fumarase with a 2- to 3fold preference for mesaconate over fumarate
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-
r
mesaconate + H2O
(S)-citramalate
heterologously produced FumD is a promiscuous mesaconase/fumarase with a 2- to 3-fold preference for mesaconate over fumarate
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-
r
mesaconate + H2O
(S)-citramalate
heterologously produced FumD is a promiscuous mesaconase/fumarase with a 2- to 3fold preference for mesaconate over fumarate
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-
r
mesaconate + H2O
(S)-citramalate
the catalytic efficiency of FumA with (S)-citramalate/mesaconate is about 4% of that with fumarate or (S)-malate
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-
r
mesaconate + H2O
(S)-citramalate
Escherichia coli ATCC 700728 / O157:H7
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heterologously produced FumD is a promiscuous mesaconase/fumarase with a 2- to 3-fold preference for mesaconate over fumarate
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-
r
mesaconate + H2O
(S)-citramalate
Escherichia coli W3110 / K-12
the catalytic efficiency of FumA with (S)-citramalate/mesaconate is about 4% of that with fumarate or (S)-malate
-
-
r
mesaconate + H2O
(S)-citramalate
Escherichia coli W3110 / K-12
heterologously produced FumD is a promiscuous mesaconase/fumarase with a 2- to 3fold preference for mesaconate over fumarate
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-
r
mesaconate + H2O
(S)-citramalate
mesaconase activity of class I fumarase contributes to mesaconate utilization by Burkholderia xenovorans. Mesaconate is metabolized through its hydration to (S)-citramalate. The first reaction of the pathway, the mesaconate hydratase (mesaconase) reaction, is catalyzed by a class I fumarase. The latter compound is then metabolized to acetyl-CoA and pyruvate with the participation of two enzymes of the itaconate degradation pathway, a promiscuous itaconate-CoA transferase able to activate (S)-citramalate in addition to itaconate and (S)-citramalyl-CoA lyase
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?
mesaconate + H2O
(S)-citramalate
Paraburkholderia xenovorans DSMZ 17367 / LB400
mesaconase activity of class I fumarase contributes to mesaconate utilization by Burkholderia xenovorans. Mesaconate is metabolized through its hydration to (S)-citramalate. The first reaction of the pathway, the mesaconate hydratase (mesaconase) reaction, is catalyzed by a class I fumarase. The latter compound is then metabolized to acetyl-CoA and pyruvate with the participation of two enzymes of the itaconate degradation pathway, a promiscuous itaconate-CoA transferase able to activate (S)-citramalate in addition to itaconate and (S)-citramalyl-CoA lyase
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Aerobic bacterium
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constitutive enzyme, the enzyme may play a role in the interconversion between S-malate and fumarate in addition to that between S-citramalate and mesaconate
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additional information
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key enzyme of the mesaconate pathway of (S)-glutamate fermentation
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