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4.2.1.34: (S)-2-methylmalate dehydratase

This is an abbreviated version!
For detailed information about (S)-2-methylmalate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.34

Reaction

(S)-2-methylmalate
=
2-methylfumarate
+
H2O

Synonyms

(+)-Citramalic hydro-lyase, Bxe_A3136, Dehydratase, citramalate, FumA, fumarase A, fumarase/mesaconase, FumD, Hydratase, mesaconate, Mesaconase, Mesaconase, mesaconate, mesaconase/fumarase, Mesaconate hydratase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.34 (S)-2-methylmalate dehydratase

Molecular Weight

Molecular Weight on EC 4.2.1.34 - (S)-2-methylmalate dehydratase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
160000
Aerobic bacterium
-
gel filtration
37000
-
enzyme consists of 2 components, neither component alone possesses hydrolase activity, MW of component I: 46000 Da, gel filtration, MW of component I: 310000 Da, gel filtration, 8 * 37000, SDS-PAGE
60000
60105
calculated from sequence
additional information
-
the enzyme consists of two components: component I has MW 45000 and component II has MW 310000, determined by gel filtration. A combination of both components gives the active enzyme. At pH 7.5 or below component II partially dissociates into species with molecular weights of about 165000, 82000, and 37000. At pH 9.0 these species reassociate to form active component II of about the original MW. The observed species may represent a monomer, dimer, tetramer and octamer of a single subunit