4.2.1.24: porphobilinogen synthase

This is an abbreviated version!
For detailed information about porphobilinogen synthase, go to the full flat file.

Reaction

2 5-aminolevulinate =

Synonyms

5-aminolaevulinic acid dehydratase, 5-aminolevulinate dehydrase, 5-aminolevulinate dehydratase, 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), 5-aminolevulinic acid dehydrase, 5-aminolevulinic acid dehydratase, 5-levulinic acid dehydratase, Al-D, ALA dehydratase, ALA synthetase, ALA-D, ALAD, ALADH, aminolevulinate dehydrase, aminolevulinate dehydratase, aminolevulinic dehydratase, CF-2, d-ALAD, delta aminolevulinic acid dehydratase, delta-ALA-D, delta-ALAD, delta-aminolevulinate dehydrase, delta-aminolevulinate dehydratase, delta-aminolevulinate dehydrataseALAD, delta-aminolevulinic acid dehydrase, delta-aminolevulinic acid dehydratase, delta-aminolevulinic dehydratase, gamma-aminolevulinic acid dehydratase, HemB, PaPBGS, PBG synthase, PBG-S, PBG-synthase, PBGS, Pcal_1709, PfALAD, PGBS, Porphobilinogen synthase, porphobilinogen synthetase, synthase, porphobilinogen, TgPBGS

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.24 porphobilinogen synthase

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Results	in table
8	Activating Compound
38384	AA Sequence
13	Application
1	CAS Registry Number
20	Cloned(Commentary)
15	Crystallization (Commentary)
736	Disease/ Diagnostics
3	Expression
11	General Information
3	General Stability
34	IC50 Value
220	Inhibitors
1	kcat/KM [mM/s]
27	Ki Value [mM]
36	KM Value [mM]
11	Localization
89	Metals/Ions
70	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
522	Organism
2	Oxidation Stability
8	Pathway
81	PDB ID
42	pH Optimum
7	pH Range
1	pH Stability
1	pI Value
25	Protein Variants
35	Purification (Commentary)
8	Reaction
3	Reaction Type
194	Reference
116	Source Tissue
27	Specific Activity [micromol/min/mg]
3	Storage Stability
117	Substrates and Products (Substrate)
36	Subunits
109	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
2	Turnover Number [1/s]

Synonyms

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Synonyms on EC 4.2.1.24 - porphobilinogen synthase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5-aminolaevulinic acid dehydratase

Rattus sp.

-

-

691205

5-aminolevulinate dehydrase

-

-

-

-

5-aminolevulinate dehydratase

4 entries

5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)

-

-

-

-

5-aminolevulinic acid dehydrase

-

-

-

-

5-aminolevulinic acid dehydratase

2 entries

5-levulinic acid dehydratase

-

-

-

-

Al-D

Homo sapiens

-

-

210691

ALA dehydratase

Agrobacterium tumefaciens

-

-

701765

ALA synthetase

Gallus gallus

-

-

210704

ALA-D

2 entries

ALAD

12 entries

ALADH

-

-

-

-

aminolevulinate dehydrase

-

-

-

-

aminolevulinate dehydratase

-

-

-

-

aminolevulinic dehydratase

-

-

-

-

CF-2

Homo sapiens

-

240-kDa proteasome inhibitor

210724

d-ALAD

Homo sapiens

-

-

666988

delta aminolevulinic acid dehydratase

Rattus norvegicus

-

-

729333

delta-ALA-D

4 entries

delta-ALAD

2 entries

delta-aminolevulinate dehydrase

-

-

-

-

delta-aminolevulinate dehydratase

5 entries

delta-aminolevulinate dehydrataseALAD

Mus musculus

-

-

728984

delta-aminolevulinic acid dehydrase

-

-

-

-

delta-aminolevulinic acid dehydratase

8 entries

delta-aminolevulinic dehydratase

2 entries

gamma-aminolevulinic acid dehydratase

-

-

-

-

HemB

2 entries

PaPBGS

Pseudomonas aeruginosa

Q59643

-

678204

PBG synthase

Desulfovibrio vulgaris

Q72DS3

-

696120

PBG-S

Saccharomyces cerevisiae

-

-

649625

PBG-synthase

2 entries

PBGS

5 entries

Pcal_1709

2 entries

PfALAD

Plasmodium falciparum

-

-

652563

PGBS

Escherichia coli

-

-

210728

Porphobilinogen synthase

7 entries

porphobilinogen synthetase

-

-

-

-

synthase, porphobilinogen

-

-

-

-

TgPBGS

Toxoplasma gondii

-

-

704678

5-aminolevulinate dehydratase

-

-

-

-

5-aminolevulinate dehydratase

Agrobacterium tumefaciens

-

-

701765

5-aminolevulinate dehydratase

Escherichia coli

-

-

691351

5-aminolevulinate dehydratase

Escherichia coli Rosetta(DE3)

-

-

-

5-aminolevulinic acid dehydratase

-

-

-

-

5-aminolevulinic acid dehydratase

Zea mays

-

-

730630

ALA-D

Homo sapiens

-

-

210685, 679261

ALA-D

Rattus norvegicus

-

-

664767

ALAD

-

-

-

-

ALAD

Gammarus pulex

-

-

679956

ALAD

Haloarcula argentinensis

-

-

727376

ALAD

Homo sapiens

-

-

713748

ALAD

Homo sapiens

P13716

-

746631

ALAD

Ictalurus punctatus

-

-

210726

ALAD

Mus musculus

-

-

652563

ALAD

Oncorhynchus mykiss

-

-

703782

ALAD

Plasmodium falciparum

-

-

652563

ALAD

Rattus norvegicus

-

-

681018, 714924

ALAD

Saccharomyces cerevisiae

P05373

-

649757, 663501

ALAD

Zea mays

-

-

716637, 730630

delta-ALA-D

Homo sapiens

-

-

651009, 677436, 678572, 679258, 682908, 702882, 714758

delta-ALA-D

Mus musculus

-

-

653996, 728984, 729907

delta-ALA-D

Rattus norvegicus

-

-

679181, 682119, 716429, 729333

delta-ALA-D

Rattus norvegicus Wistar

-

-

-

delta-ALAD

-

-

-

-

delta-ALAD

Homo sapiens

-

-

730290

delta-aminolevulinate dehydratase

-

-

-

-

delta-aminolevulinate dehydratase

Homo sapiens

-

-

693344, 694568, 714758

delta-aminolevulinate dehydratase

Mus musculus

-

-

729907

delta-aminolevulinate dehydratase

Rattus norvegicus

-

-

691169, 716429

delta-aminolevulinate dehydratase

Rattus norvegicus Wistar

-

-

-

delta-aminolevulinic acid dehydratase

-

-

-

-

delta-aminolevulinic acid dehydratase

Chamelea gallina

-

-

693971

delta-aminolevulinic acid dehydratase

Haloarcula argentinensis

-

-

727376

delta-aminolevulinic acid dehydratase

Homo sapiens

-

-

713748, 730290

delta-aminolevulinic acid dehydratase

Parus major

-

-

695128

delta-aminolevulinic acid dehydratase

Rattus norvegicus

-

-

691672, 695196

delta-aminolevulinic acid dehydratase

Streptomyces yokosukanensis

-

-

694843

delta-aminolevulinic acid dehydratase

Zea mays

-

-

716637

delta-aminolevulinic dehydratase

-

-

-

-

delta-aminolevulinic dehydratase

Rattus norvegicus

-

-

714924

HemB

Escherichia coli

-

-

749311

HemB

Escherichia coli

P0ACB2

-

746631

PBG-synthase

Rattus norvegicus

-

-

716429

PBG-synthase

Rattus norvegicus Wistar

-

-

-

PBGS

Bos taurus

-

-

666966

PBGS

Drosophila melanogaster

-

-

652435

PBGS

Homo sapiens

P13716

-

652574, 680737, 704601

PBGS

Rhodobacter capsulatus

Q6IVV3

-

664453

PBGS

Saccharomyces cerevisiae

-

-

716012

Pcal_1709

Pyrobaculum calidifontis

A3MWV9

locus name

746631

Pcal_1709

Pyrobaculum calidifontis JCM 11548

A3MWV9

locus name

-

Porphobilinogen synthase

-

-

-

-

Porphobilinogen synthase

Desulfovibrio vulgaris

Q72DS3

-

696120

Porphobilinogen synthase

Homo sapiens

P13716

-

690939, 704601

Porphobilinogen synthase

Pisum sativum

-

-

690898

Porphobilinogen synthase

Pseudomonas aeruginosa

Q59643

-

701747

Porphobilinogen synthase

Rattus sp.

-

-

691205

Porphobilinogen synthase

Toxoplasma gondii

-

-

704678