4.2.1.24: porphobilinogen synthase
This is an abbreviated version!
For detailed information about porphobilinogen synthase, go to the full flat file.
Word Map on EC 4.2.1.24
-
4.2.1.24
-
erythrocyte
-
heme
-
protoporphyrin
-
urinary
-
poison
-
catalase
-
workers
-
hemoglobin
-
porphyria
-
intoxication
-
urine
-
anemia
-
deaminase
-
thiobarbituric
-
gsh
-
tbars
-
succinylacetone
-
hematocrit
-
cadmium
-
hematological
-
uroporphyrinogen
-
ferrochelatase
-
tetrapyrrole
-
diselenide
-
octamer
-
lead-induced
-
delta-aminolaevulinic
-
lead-exposed
-
diphenyl
-
coproporphyria
-
cutanea
-
uroporphyrins
-
tarda
-
dimercaptosuccinic
-
coproporphyrinogen
-
smelter
-
tyrosinemia
-
peribiliary
-
occupationally
-
erythropoietic
-
medicine
-
bandgaps
-
porphyrinogenic
-
arsenic-induced
-
synthesis
-
analysis
-
organoselenium
-
proto
-
toxicokinetics
-
micrograms/100
-
furnace
-
environmental protection
-
diagnostics
- 4.2.1.24
- erythrocyte
- heme
- protoporphyrin
- urinary
-
poison
- catalase
-
workers
- hemoglobin
- porphyria
-
intoxication
- urine
- anemia
- deaminase
-
thiobarbituric
- gsh
-
tbars
- succinylacetone
-
hematocrit
- cadmium
-
hematological
- uroporphyrinogen
-
ferrochelatase
- tetrapyrrole
- diselenide
-
octamer
-
lead-induced
-
delta-aminolaevulinic
-
lead-exposed
-
diphenyl
- coproporphyria
-
cutanea
- uroporphyrins
- tarda
-
dimercaptosuccinic
- coproporphyrinogen
-
smelter
- tyrosinemia
-
peribiliary
-
occupationally
-
erythropoietic
- medicine
-
bandgaps
-
porphyrinogenic
-
arsenic-induced
- synthesis
- analysis
-
organoselenium
-
proto
-
toxicokinetics
-
micrograms/100
-
furnace
- environmental protection
- diagnostics
Reaction
2 5-aminolevulinate
=
Synonyms
5-aminolaevulinic acid dehydratase, 5-aminolevulinate dehydrase, 5-aminolevulinate dehydratase, 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), 5-aminolevulinic acid dehydrase, 5-aminolevulinic acid dehydratase, 5-levulinic acid dehydratase, Al-D, ALA dehydratase, ALA synthetase, ALA-D, ALAD, ALADH, aminolevulinate dehydrase, aminolevulinate dehydratase, aminolevulinic dehydratase, CF-2, d-ALAD, delta aminolevulinic acid dehydratase, delta-ALA-D, delta-ALAD, delta-aminolevulinate dehydrase, delta-aminolevulinate dehydratase, delta-aminolevulinate dehydrataseALAD, delta-aminolevulinic acid dehydrase, delta-aminolevulinic acid dehydratase, delta-aminolevulinic dehydratase, gamma-aminolevulinic acid dehydratase, HemB, PaPBGS, PBG synthase, PBG-S, PBG-synthase, PBGS, Pcal_1709, PfALAD, PGBS, Porphobilinogen synthase, porphobilinogen synthetase, synthase, porphobilinogen, TgPBGS
ECTree
4.2.1.24 porphobilinogen synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.2.1.24 - porphobilinogen synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-aminolevulinate
?
-
induction by 17beta-estradiol of 5-aminolevulinate
-
-
?
5-aminolevulinate
?
-
during erythropoiesis in chordates the enzyme functions as a part of the heme synthesizing machinery
-
-
?
5-aminolevulinate
?
-
second enzyme in the heme biosynthetic pathway
-
-
?
5-aminolevulinate
?
-
the second and rate-limiting enzyme of the heme-biosynthetic pathway
-
-
?
5-aminolevulinate
?
-
enzyme catalyzes the first common step in tetrapyrrole biosynthesis
-
-
?
5-aminolevulinate
?
enzyme catalyzes the first common step in tetrapyrrole biosynthesis
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
(3R)-5-aminolevulinate shows a significantly larger isotope effect than (3S)-5-aminolevulinate
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
(3R)-5-aminolevulinate shows a significantly larger isotope effect than (3S)-5-aminolevulinate
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
essential step in tetrapyrrole biosynthesis
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
the enzyme catalyzes the first common step in the biosynthesis of tetrapyrroles
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
the enzyme functions in the first common step in tetrapyrrole biosynthesis
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
incubations of erythrocytes for 24 h with glucose result in an increase of delta-ALA-D activity. Incubations of erythrocytes with 100 to 200 mM glucose for 48 h inhibit delta-ALA-D activity
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
the role of the enzyme may be confined to heme synthesis in the apicoplast that may not account for the total de novo heme biosynthesis in the parasite
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
porphobilinogen synthase catalyzes the first committed step of the tetrapyrrole biosynthesis pathway
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
enzymatic mechanism starts with formation of a C-C bond, linking C3 of the A-side 5-aminolevulinic acid to C4 of the P-side 5-aminolevulinic acid through an aldole addition
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
the enzyme catalyzes the third step of tetrapyrrole synthesis leading to the formation of heme and chlorophylls in plant tissues. In the light, both 5-aminolevulinate dehydratase activity, and protein level increases 3-4 times compared to the dark-control level. However, no change in the amount of related mRNA is observed. The apparent stability of the mRNA can be due to the abundant expression of a housekeeping gene, which shadows a related gene expressed in the light
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
the enzyme plays a rate-limiting role in heme biosynthesis of saccharomyces cerevisiae
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinate + 5-aminolevulinate
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinic acid + 5-aminolevulinic acid
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinic acid + 5-aminolevulinic acid
porphobilinogen + 2 H2O
-
-
-
?
5-aminolevulinic acid + 5-aminolevulinic acid
porphobilinogen + 2 H2O
-
-
-
-
?
5-aminolevulinic acid + 5-aminolevulinic acid
porphobilinogen + 2 H2O
-
-
-
-
?
additional information
?
-
-
the enzyme has a dual role: 1. as 5-aminolevulinate dehydatase, the second enzyme in the pathway of heme synthesis, 2. as CF-2 proteasome inhibitor
-
-
?
additional information
?
-
-
direct assay method development with incubation of erythrocyte lysate with the natural substrate, 5-aminolevulinate, followed by quantitative in situ conversion of porphobilinogen to its butyramide and mass spectrometric determination, overview. Using a carbonate buffer rather than phosphate causes nearly a 90% drop in activity and addition of zinc results in a further decrease by up to 35%
-
-
?
additional information
?
-
-
the enzyme stimulates renaturation of luciferase by hsp 70, a member of the heat shock protein 70kDa-family, up to 10fold
-
-
?
additional information
?
-
-
the enzyme stimulates renaturation of luciferase by hsp 70 up to 10fold
-
-
?
additional information
?
-
-
early enzyme of the tetrapyrrole biosynthesis pathway
-
-
?
