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4.2.1.24: porphobilinogen synthase

This is an abbreviated version!
For detailed information about porphobilinogen synthase, go to the full flat file.

Word Map on EC 4.2.1.24

Reaction

2 5-aminolevulinate =

porphobilinogen
+ 2 H2O

Synonyms

5-aminolaevulinic acid dehydratase, 5-aminolevulinate dehydrase, 5-aminolevulinate dehydratase, 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), 5-aminolevulinic acid dehydrase, 5-aminolevulinic acid dehydratase, 5-levulinic acid dehydratase, Al-D, ALA dehydratase, ALA synthetase, ALA-D, ALAD, ALADH, aminolevulinate dehydrase, aminolevulinate dehydratase, aminolevulinic dehydratase, CF-2, d-ALAD, delta aminolevulinic acid dehydratase, delta-ALA-D, delta-ALAD, delta-aminolevulinate dehydrase, delta-aminolevulinate dehydratase, delta-aminolevulinate dehydrataseALAD, delta-aminolevulinic acid dehydrase, delta-aminolevulinic acid dehydratase, delta-aminolevulinic dehydratase, gamma-aminolevulinic acid dehydratase, HemB, PaPBGS, PBG synthase, PBG-S, PBG-synthase, PBGS, Pcal_1709, PfALAD, PGBS, Porphobilinogen synthase, porphobilinogen synthetase, synthase, porphobilinogen, TgPBGS

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.24 porphobilinogen synthase

Molecular Weight

Molecular Weight on EC 4.2.1.24 - porphobilinogen synthase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
183500
mutant enzyme R240A, pH 9, analytical ultracentrifugation
188500
mutant enzyme R240A, pH 7, analytical ultracentrifugation
197000
variant F12L, equilibrium sedimentation
197900
mutant enzyme F12L, pH 7, analytical ultracentrifugation
212400
mutant enzyme R240A, pH 7, dynamic light scattering
214400
mutant enzyme F12L, pH 7, dynamic light scattering
220000
gel filtration, analytical ultracentrifugation
240000
-
gel filtration
244000
252000
-
gel filtration
260000
270000
-
gel filtration
275000
-
glycerol density gradient centrifugation
280000
282000
285000
-
gel filtration
289000
-
equilibrium sedimentation
30000
-
8 * 30000, SDS-PAGE
309000
-
gel filtration
31000
-
8 * 31000, SDS-PAGE
317600
wild-type enzyme, pH 7, dynamic light scattering
32000
-
subunit of L273R, analyzed by SDS-PAGE
320000
-
gel filtration, recombinant TgPBGS is purified as a stable octamer
324000
-
density gradient centrifugation
335000
-
gel filtration
345000
-
gel filtration
34800
-
analyzed by SDS-PAGE
34900
-
8 * 34900, equilibrium sedimentation in presence of 6 M guanidine-HCl
35000
350000
-
gel filtration
35856
6 * 35856, calculation from nucleotide sequence
36000
36690
-
theoretical monomer molecular mass
37000
37832
-
6 * 37832, electrospray ionization mass spectrometry
38000
40000
42000
-
6 * 42000, SDS-PAGE
43000
-
8 * 43000, SDS-PAGE
45000
-
x * 45000, SDS-PAGE
46000
-
8 * 46000, mature recombinant enzyme, SDS-PAGE
50000
-
6 * 50000, SDS-PAGE
69600
mutant enzyme W19A, pH 7, analytical ultracentrifugation
78600
mutant enzyme W19A, pH 7, dynamic light scattering
additional information