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4.2.1.24: porphobilinogen synthase

This is an abbreviated version!
For detailed information about porphobilinogen synthase, go to the full flat file.

Word Map on EC 4.2.1.24

Reaction

2 5-aminolevulinate =

porphobilinogen
+ 2 H2O

Synonyms

5-aminolaevulinic acid dehydratase, 5-aminolevulinate dehydrase, 5-aminolevulinate dehydratase, 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), 5-aminolevulinic acid dehydrase, 5-aminolevulinic acid dehydratase, 5-levulinic acid dehydratase, Al-D, ALA dehydratase, ALA synthetase, ALA-D, ALAD, ALADH, aminolevulinate dehydrase, aminolevulinate dehydratase, aminolevulinic dehydratase, CF-2, d-ALAD, delta aminolevulinic acid dehydratase, delta-ALA-D, delta-ALAD, delta-aminolevulinate dehydrase, delta-aminolevulinate dehydratase, delta-aminolevulinate dehydrataseALAD, delta-aminolevulinic acid dehydrase, delta-aminolevulinic acid dehydratase, delta-aminolevulinic dehydratase, gamma-aminolevulinic acid dehydratase, HemB, PaPBGS, PBG synthase, PBG-S, PBG-synthase, PBGS, Pcal_1709, PfALAD, PGBS, Porphobilinogen synthase, porphobilinogen synthetase, synthase, porphobilinogen, TgPBGS

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.24 porphobilinogen synthase

IC50 Value

IC50 Value on EC 4.2.1.24 - porphobilinogen synthase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
30
1-amino-4-methoxy-2-butanone
Rattus sp.
-
-
32.5
1-amino-5-hydroxy-2-pentanone
Rattus sp.
-
-
0.31
5,5'-iminobis(4-oxopentanoic acid)
Pseudomonas aeruginosa
-
-
0.96
5,5'-oxybis(4-oxopentanoic acid)
Pseudomonas aeruginosa
-
-
38
5,5'-sulfinylbis(4-oxopentanoic acid)
Pseudomonas aeruginosa
-
-
9.9
5,5'-sulfonylbis(4-oxopentanoic acid)
Pseudomonas aeruginosa
-
-
0.34
5,5'-thiobis(4-oxopentanoic acid)
Pseudomonas aeruginosa
-
-
0.01
7-(3-aminopentan-3-yl)-5-chloroquinolin-8-ol
Homo sapiens
-
0.319
Al3+
Bos taurus
-
IC50: 0.319 mM, GSH has no protective effect
1.33
alaremycin
Pseudomonas aeruginosa
-
0.004
alloxan
Mus musculus
-
pH 6.4 and 37°C
0.01917 - 0.0345
Cd2+
0.01 - 0.985
dibutyl diselenide
0.00195 - 0.274
diphenyl diselenide
0.442
Ga3+
Bos taurus
-
inhibits by competing with Zn2+, IC50: 0.442 mM, GSH has no protective effect, Zn2+ completely recovers inhibition
0.298
In3+
Bos taurus
-
inhibits by competing with Zn2+, IC50: 0.298 mM, GSH reduces inhibition, DL-dithiothreitol has modest effect on inhibition, Zn2+ completely recovers inhibition
0.058
N-(3-methoxyphenyl)-1-methyl-6-oxo-2-[(pyridin-2-ylmethyl)sulfanyl]-1,6-dihydropyrimidine-5-carboxamide
Homo sapiens
-
0.0056 - 0.0062
Pb2+
0.25 - 0.4
phenyl selenoacetylene
0.045 - 0.1
phenyl selenoxideacetylene
0.005 - 0.902
sodium selenide
0.001
succinylacetone
Toxoplasma gondii
-
-
0.0085
Tl3+
Bos taurus
-
inhibits by direct oxidation of essential sulfhydryl groups, IC50: 0.0085 mM, DL-dithiothreitol restores completely enzyme activity inhibited by Tl3+, Zn2+ is unable to change inhibition