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4.2.1.22: cystathionine beta-synthase

This is an abbreviated version!
For detailed information about cystathionine beta-synthase, go to the full flat file.

Word Map on EC 4.2.1.22

Reaction

L-serine
+
L-homocysteine
=
L-cystathionine
 +
H2O

Synonyms

Beta-thionase, CBS, CBS424, CDCP2, CNNM2, Cys4, CysB, cystathionine beta synthase, cystathionine beta-synthase, cystathionine beta-synthase domain-containing protein, cystathionine-beta-synthase, Cysteine synthase, EC 4.2.1.21, hCBS, Hemoprotein H-450, LbrM.17.0230, Methylcysteine synthase, osmoprotectant transporter OpuC, PF1953, PH0267, Serine sulfhydrase, Serine sulfhydrylase, Serine sulphhydrase, TA0289, TM0935, TV1335, yCBS, ytCBS

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.22 cystathionine beta-synthase

Inhibitors

Inhibitors on EC 4.2.1.22 - cystathionine beta-synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(5Z)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-methyl-2-(methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one
-
compound derived from polyandrocarpamines A and B, i.e. 2-aminoimidazolone compounds isolated from the ascidian Polyandrocarpa sp.
2,4-Dichlorophenol
2-methoxy-4-[(Z)-(5-oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]phenyl acetate
-
compound derived from polyandrocarpamines A and B, i.e. 2-aminoimidazolone compounds isolated from the ascidian Polyandrocarpa sp.
alizarin
Amino-oxyacetate
-
complete inhibition at 0.05 mM
aminooxyacetic acid
beta-chloro-L-alanine
-
-
bithionol
carbon monoxide
closantel
Co3+
-
Co3+ has 30-60% of the specific activity of Fe3+-CBS
cyanide
-
-
Dichlorophene
Dithionite
-
2fold decrease in enzyme activity due to altered oxidation state of the heme
ellagic acid
Hexachlorophene
Hg2+
-
reactivity of Co(III) hCBS with HgCl2 is consistent with a loss of the cysteine(thiolate) ligand. 2-Mercaptoethanol is unable to reverse the Hg-induced ligand switch, in contrast to some other heme-thiolate proteins
HgCl2
hydroxylamine
iodoacetate
-
-
L-cystathione
-
product inhibition
L-homocysteine
Mn3+
-
Mn3+ has 30-60% of the specific activity of Fe3+-CBS
nitric oxide
p-chloromercuribenzoate
-
-
peroxynitrite
exposure to peroxynitrite does not modify bound pyridoxal 5'-phosphate but leads to nitration of Trp208, Trp43 and Tyr223 and alterations in the heme environment including loss of thiolate coordination, conversion to high-spin and bleaching, with no detectable formation of oxoferryl compounds nor promotion of one-electron processes
purpurogallin
quercetin
Rafoxanide
regulatory domain
-
exerts an inhibitory effect on the enzyme, deletion is correlated with a 1fold increase in catalytic activity
-
titanium citrate
-
2fold decrease in enzyme activity due to altered oxidation state of the heme
additional information
-