4.2.1.18: methylglutaconyl-CoA hydratase
This is an abbreviated version!
For detailed information about methylglutaconyl-CoA hydratase, go to the full flat file.
Word Map on EC 4.2.1.18
-
4.2.1.18
-
acidurias
-
3-methylglutaconic
-
urine
-
inborn
-
3-methylglutaric
-
speech
-
3-methylcrotonyl-coa
-
3-hydroxyisovaleric
-
hypotonia
-
enoyl-coas
-
psychomotor
-
isovaleryl-coa
-
thiolase
-
medicine
- 4.2.1.18
-
acidurias
-
3-methylglutaconic
- urine
-
inborn
-
3-methylglutaric
-
speech
- 3-methylcrotonyl-coa
-
3-hydroxyisovaleric
-
hypotonia
- enoyl-coas
-
psychomotor
- isovaleryl-coa
-
thiolase
- medicine
Reaction
Synonyms
(3S)-methylglutaconyl-CoA hydratase, 3-methylglutaconyl CoA hydratase, 3-methylglutaconyl-CoA hydratase, 3-MG-CoA, 3-MGCoA-H, 3MGH, At4g16800, AU RNA binding protein/enoyl-Coenzyme A hydratase, AUH, HMG-CoA hydrolyase, hydratase, methylglutaconyl coenzyme A, LiuC, methylglutaconase, methylglutaconyl coenzyme A hydratase, MG-CoA hydratase, MGCH, Tb427.10.4000
ECTree
4.2.1.18 methylglutaconyl-CoA hydrataseAdvanced search results
results (
results (Reference
top
Reference on EC 4.2.1.18 - methylglutaconyl-CoA hydratase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Messner, B.; Eggerer, H.; Cornforth, J.W.; Mallaby, R.
Substrate stereochemistry of the hydroxymethylglutaryl-CoA lyase and methylglutaconyl-CoA hydratase reactions
Eur. J. Biochem.
53
255-264
1975
Ovis aries
-
Hilz, H.; Knappe, J.; Ringelmann, E.; Lynen, F.
Methylglutaconase, eine neue Hydratase, die am Stoffwechsel verzweigter Carbonsaeuren beteiligt ist
Biochem. Z.
329
476-489
1958
Bos taurus
-
Hermans-Lokkerbol, A.; van der Heijden, R.; Verpoorte, R.
Isocratic high-performance liquid chromatography of coenzyme A esters involved in the metabolism of 3S-hydroxy-3-methylglutaryl-coenzyme A. Detection of related enzyme activities in Catharanthus roseus plant cell culture
J. Chromatogr. A
752
123-130
1996
Catharanthus roseus
-
Gibson, K.M.
Assay of 3-methylglutaconyl-CoA hydratase
Methods Enzymol.
166
214-218
1988
Homo sapiens
Gibson, K.M.
3-Methylglutaconyl-coenzyme-A hydratase deficiency: a new case
J. Inherit. Metab. Dis.
15
363-366
1992
Homo sapiens
Narisawa, K.; Gibson, K.M.; Sweetman, L.; Nyhan, W.L.
3-Methylglutaconyl-CoA hydratase, 3-methylcrotonyl-CoA carboxylase and 3-hydroxy-3-methylglutaryl-CoA lyase deficiencies: a coupled enzyme assay useful for their detection
Clin. Chim. Acta
184
57-64
1989
Homo sapiens
Van der Heijden, R.; de Boer-Hlupa, V.; Verpoorte, R.; Duine, J.A.
Enzymes involved in the metabolism of 3-hydroxy-3-methylglutaryl-coenzyme A in Catharanthus roseus
Plant Cell
38
345-349
1994
Catharanthus roseus
-
Wong, B.J.; Gerlt, J.A.
Evolution of function in the crotonase superfamily: (3S)-methylglutaconyl-CoA hydratase from Pseudomonas putida
Biochemistry
43
4646-4654
2004
Pseudomonas putida, Pseudomonas putida PA2011
Loupatty, F.J.; Ruiter, J.P.N.; Ijlst, L.; Duran, M.; Wanders, R.J.A.
Direct nonisotopic assay of 3-methylglutaconyl-CoA hydratase in cultured human skin fibroblasts to specifically identify patients with 3-methylglutaconic aciduria type I
Clin. Chem.
50
1447-1450
2004
Homo sapiens
Mack, M.; Liesert, M.; Zschocke, J.; Peters, V.; Linder, D.; Buckel, W.
3-Methylglutaconyl-CoA hydratase from Acinetobacter sp
Arch. Microbiol.
185
297-306
2006
Acinetobacter sp. (Q3HW12), Acinetobacter sp., Acinetobacter sp. DSM 11652 (Q3HW12)
Mack, M.; Schniegler-Mattox, U.; Peters, V.; Hoffmann, G.F.; Liesert, M.; Buckel, W.; Zschocke, J.
Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism
FEBS J.
273
2012-2022
2006
Homo sapiens (Q13825), Homo sapiens
Di Rosa, G.; Deodato, F.; Loupatty, F.J.; Rizzo, C.; Carrozzo, R.; Santorelli, F.M.; Boenzi, S.; DAmico, A.; Tozzi, G.; Bertini, E.; Maiorana, A.; Wanders, R.J.; Dionisi-Vici, C.
Hypertrophic cardiomyopathy, cataract, developmental delay, lactic acidosis: a novel subtype of 3-methylglutaconic aciduria
J. Inherit. Metab. Dis.
29
546-550
2006
Homo sapiens (Q13825), Homo sapiens
Kurimoto, K.; Kuwasako, K.; Sandercock, A.; Unzai, S.; Robinson, C.; Muto, Y.; Yokoyama, S.
AU-rich RNA-binding induces changes in the quaternary structure of AUH
Proteins
75
360-372
2009
Homo sapiens (Q13825), Homo sapiens
Mercimek-Mahmutoglu, S.; Tucker, T.; Casey, B.
Phenotypic heterogeneity in two siblings with 3-methylglutaconic aciduria type I caused by a novel intragenic deletion
Mol. Genet. Metab.
104
410-413
2011
Homo sapiens
Su, B.; Ryan, R.O.
Metabolic biology of 3-methylglutaconic acid-uria: a new perspective
J. Inherit. Metab. Dis.
37
359-368
2014
Homo sapiens (Q13825)
Bock, T.; Reichelt, J.; Mueller, R.; Blankenfeldt, W.
The Structure of LiuC, a 3-hydroxy-3-methylglutaconyl CoA dehydratase involved in isovaleryl-CoA biosynthesis in Myxococcus xanthus, reveals insights into specificity and catalysis
ChemBioChem
17
1658-1664
2016
Myxococcus xanthus (Q1D5Y4), Myxococcus xanthus DK 1622 (Q1D5Y4)
de Lima Stein, M.L.; Icimoto, M.Y.; de Castro Levatti, E.V.; Oliveira, V.; Straus, A.H.; Schenkman, S.
Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei
Mol. Biochem. Parasitol.
214
36-46
2017
Trypanosoma brucei, Trypanosoma brucei Lister 427
Latimer, S.; Li, Y.; Nguyen, T.T.H.; Soubeyrand, E.; Fatihi, A.; Elowsky, C.G.; Block, A.; Pichersky, E.; Basset, G.J.
Metabolic reconstructions identify plant 3-methylglutaconyl-CoA hydratase that is crucial for branched-chain amino acid catabolism in mitochondria
Plant J.
95
358-370
2018
Arabidopsis thaliana (F4JML5)
html completed
