4.2.1.12: phosphogluconate dehydratase

This is an abbreviated version!
For detailed information about phosphogluconate dehydratase, go to the full flat file.

Reaction

Synonyms

6-PG dehydrase, 6-phospho-D-gluconate dehydratase, 6-phosphogluconate dehydrase, 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, 6PGDT, dehydratase, phosphogluconate, EDD, Edd protein, gluconate 6-phosphate dehydratase, gluconate-6-phosphate dehydratase, PGDH

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.12 phosphogluconate dehydratase

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Results	in table
1	Activating Compound
10714	AA Sequence
1	Application
1	CAS Registry Number
2	Cloned(Commentary)
1	Cofactor
1	Expression
6	General Information
2	General Stability
7	Inhibitors
2	KM Value [mM]
9	Metals/Ions
3	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
52	Organism
2	Oxidation Stability
6	Pathway
2	PDB ID
1	pH Optimum
2	Purification (Commentary)
3	Reaction
1	Reaction Type
45	Reference
2	Source Tissue
4	Specific Activity [micromol/min/mg]
76	Substrates and Products (Substrate)
2	Subunits
21	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]

Substrates Products

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Substrates Products on EC 4.2.1.12 - phosphogluconate dehydratase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

6-phospho-D-gluconate

2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O

2 entries

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

48 entries

6-phospho-D-gluconate

?

25 entries

additional information

?

-

Escherichia coli

-

multicopy plasmid suppression of stationary phase chaperone toxicity in E. coli by phosphogluconate dehydratase and the N-terminus of DnaK

33657

-

-

?

6-phospho-D-gluconate

2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O

Saccharomyces cerevisiae

-

-

730093

-

-

?

6-phospho-D-gluconate

2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O

Vibrio cholerae serotype O1

-

-

729922

-

-

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Acidiphilium cryptum

-

-

4980

-

4980

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Bradyrhizobium japonicum

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Bradyrhizobium japonicum CC409

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Bradyrhizobium lupini

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Bradyrhizobium lupini RL3001

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Escherichia coli

-

-

33654

-

33654

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Escherichia coli

-

-

33657

-

33657

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Escherichia coli

-

-

33658

-

33658

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Legionella pneumophila

-

-

704329

-

-

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Legionella pneumophila AM511

-

-

704329

-

-

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Mesorhizobium loti

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Mesorhizobium loti NZP2213

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Methylobacillus glycogenes

-

-

33645

-

33645

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Methylobacillus sp.

-

-

33645

-

33645

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Methylobacillus sp. VSB-792

-

-

33645

-

33645

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Methylophilus methanolovorus

-

-

33645

-

33645

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Nitrospirillum amazonense

-

-

33647

-

33647

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pelomonas saccharophila

-

-

33655

-

33655

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Protaminobacter candidus

-

-

33645

-

33645

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas aeruginosa

-

-

33648

-

33648

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas chlororaphis

Q1PAG1

Entner-Doudoroff pathway

681712

-

-

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas chlororaphis

Q1PAG1

mutants deficient of 6-phosphogluconate dehydratase grow on succinate but not on glucose, role of 6-phosphogluconate dehydratase in metabolism during root colonisation and induction of systemic resistance

681712

-

-

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas chlororaphis O6

Q1PAG1

Entner-Doudoroff pathway

681712

-

-

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas chlororaphis O6

Q1PAG1

mutants deficient of 6-phosphogluconate dehydratase grow on succinate but not on glucose, role of 6-phosphogluconate dehydratase in metabolism during root colonisation and induction of systemic resistance

681712

-

-

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas fluorescens

-

-

33653

-

33653

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas fluorescens

-

-

33656

-

33656

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas fluorescens A3.12

-

-

33656

-

33656

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas mildenbergii

-

-

33655

-

33655

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas putida

-

-

33651

-

33651

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Pseudomonas putida

-

-

33655

-

33655

ir

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium leguminosarum

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium leguminosarum CC224

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium leguminosarum SU391

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium phaseoli

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium phaseoli CC365

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium sp.

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium sp.

-

-

33649

-

33649

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium sp. BICC609

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium sp. BICC610

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium sp. BICC613

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium sp. BICC614

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Rhizobium sp. U8

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Sinorhizobium meliloti

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Sinorhizobium meliloti SU216

-

-

4981

-

4981

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Xanthomonas oryzae pv. oryzae

-

-

702838

-

-

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Xanthomonas oryzae pv. oryzae KACC10859

-

-

702838

-

-

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Zymomonas mobilis

-

-

33650

-

33650

?

6-phospho-D-gluconate

6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O

Zymomonas mobilis

-

-

33652

-

33652

?

6-phospho-D-gluconate

?

Acidiphilium cryptum

-

key enzyme of the pentose phosphate pathway and the Entner-Doudoroff pathway

4980

-

-

?

6-phospho-D-gluconate

?

Bradyrhizobium japonicum

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Bradyrhizobium japonicum CC409

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Bradyrhizobium lupini

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Bradyrhizobium lupini RL3001

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Mesorhizobium loti

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Mesorhizobium loti NZP2213

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Pelomonas saccharophila

-

-

33655

-

-

?

6-phospho-D-gluconate

?

Pseudomonas fluorescens

-

the enzyme is significantly induced at all stages of growth assayed

33653

-

-

?

6-phospho-D-gluconate

?

Pseudomonas mildenbergii

-

-

33655

-

-

?

6-phospho-D-gluconate

?

Pseudomonas putida

-

-

33655

-

-

?

6-phospho-D-gluconate

?

Rhizobium leguminosarum

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium leguminosarum CC224

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium leguminosarum SU391

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium phaseoli

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium phaseoli CC365

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium sp.

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium sp. BICC609

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium sp. BICC610

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium sp. BICC613

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium sp. BICC614

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Rhizobium sp. U8

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Sinorhizobium meliloti

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Sinorhizobium meliloti SU216

-

enzyme of the Entner-Doudoroff pathway

4981

-

-

?

6-phospho-D-gluconate

?

Zymomonas mobilis

-

key enzyme in the Entner-Doudoroff pathway

33652

-

-

?