4.1.3.32: 2,3-Dimethylmalate lyase

This is an abbreviated version!
For detailed information about 2,3-Dimethylmalate lyase, go to the full flat file.

Reaction

Synonyms

(2R,3S)-dimethylmalate lyase, 2,3-dimethylmalate lyase, An07g08390, DMML, Lyase, 2,3-dimethylmalate

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.32 2,3-Dimethylmalate lyase

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Results	in table
2	Activating Compound
376	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
3	Crystallization (Commentary)
1	General Information
14	Inhibitors
13	kcat/KM [mM/s]
16	Ki Value [mM]
54	KM Value [mM]
12	Metals/Ions
12	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
8	Organism
3	Pathway
28	PDB ID
3	pH Optimum
1	pH Range
20	Protein Variants
4	Purification (Commentary)
2	Reaction
8	Reference
35	Substrates and Products (Substrate)
6	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
69	Turnover Number [1/s]

Reference

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Reference on EC 4.1.3.32 - 2,3-Dimethylmalate lyase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

5349

Pirzer, P.; Lill, U.; Eggerer, H.

Nicotinic acid metabolism. 2,3-Dimethylmalate lyase

Hoppe-Seyler's Z. Physiol. Chem.

360

1693-1702

1979

Eubacterium barkeri

527937

brenda

5350

Lill, U.; Pirzer, P.; Kukla, D.; Huber, R.; Eggerer, H.

Nicotinic acid metabolism. Enzymic preparation and absolute configuration of the substrate for 2,3-dimethylmalate lyase

Hoppe-Seyler's Z. Physiol. Chem.

361

875-884

1980

Eubacterium barkeri

7399408

brenda

5351

L�hlein, G.; Eggerer, H.

Nicotinic acid metabolism. Stereochemical course of the (2R,3S)-2,3-dimethylmalate lyase reaction

Hoppe-Seyler's Z. Physiol. Chem.

363

1103-1109

1982

Eubacterium barkeri

7141415

brenda

5352

Eggerer, H.

Completion of the degradation scheme for nicotinic acid by Clostridium barkeri

Curr. Top. Cell. Regul.

26

411-418

1985

Eubacterium barkeri

4075828

brenda

670692

Alhapel, A.; Darley, D.J.; Wagener, N.; Eckel, E.; Elsner, N.; Pierik, A.J.

Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri

Proc. Natl. Acad. Sci. USA

103

12341-12346

2006

Eubacterium barkeri

16894175

brenda

693684

Narayanan, B.; Niu, W.; Joosten, H.J.; Li, Z.; Kuipers, R.K.; Schaap, P.J.; Dunaway-Mariano, D.; Herzberg, O.

Structure and function of 2,3-dimethylmalate lyase, a PEP mutase/isocitrate lyase superfamily member

J. Mol. Biol.

386

486-503

2009

Aspergillus niger (Q2L887), Aspergillus niger

19133276

brenda

748428

Chotpatiwetchkul, W.; Jongkon, N.; Hannongbua, S.; Gleeson, M.P.

QM/MM investigation of the reaction rates of substrates of 2,3-dimethylmalate lyase A catabolic protein isolated from Aspergillus niger

J. Mol. Graph. Model.

68

29-38

2016

Aspergillus niger

27343740

brenda

748460

Jongkon, N.; Chotpatiwetchkul, W.; Gleeson, M.P.

Probing the catalytic mechanism involved in the isocitrate lyase superfamily hybrid quantum mechanical/molecular mechanical calculations on 2,3-dimethylmalate lyase

J. Phys. Chem. B

119

11473-11484

2015

Mycobacterium tuberculosis

26224328

brenda

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