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4.1.3.30: Methylisocitrate lyase

This is an abbreviated version!
For detailed information about Methylisocitrate lyase, go to the full flat file.

Word Map on EC 4.1.3.30

Reaction

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate
=
succinate
+
pyruvate

Synonyms

2-Methylisocitrate lyase, Lyase, methylisocitrate, MCL, Mcl1, methylisocitrate lyase, MICL, mmgF, PrpB, TgPrpB, yqiQ

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.30 Methylisocitrate lyase

Inhibitors

Inhibitors on EC 4.1.3.30 - Methylisocitrate lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4E)-4-[(4,7-dichloro-2-phenyl-1H-indol-3-yl)methylidene]-2,4-dihydro-3H-pyrazol-3-one
-
-
(4E)-4-[(5-methyl-2-phenyl-1H-indol-3-yl)methylidene]-2,4-dihydro-3H-pyrazol-3-one
-
-
(4E)-4-[(6,7-dichloro-2-phenyl-1H-indol-3-yl)methylidene]-2,4-dihydro-3H-pyrazol-3-one
-
-
(4Z)-5-methyl-4-[(1H-pyrrol-2-yl)methylidene]-2,4-dihydro-3H-pyrazol-3-one
-
-
(4Z)-5-methyl-4-[(pyridin-4-yl)methylidene]-2,4-dihydro-3H-pyrazol-3-one
-
-
3-(4,7-dichloro-2-phenyl-1H-indol-3-yl)-4-methyl-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carbothioamide
-
-
3-(6,7-dichloro-2-phenyl-1H-indol-3-yl)-4-methyl-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carbothioamide
-
-
3-(6,7-dichloro-2-phenyl-1H-indol-3-yl)-4-methyl-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carboxamide
-
-
3-Bromopyruvate
-
complete inactivation at equimolar concentrations
4-methyl-3-(1H-pyrrol-2-yl)-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carboxamide
-
-
4-methyl-3-(5-methyl-2-phenyl-1H-indol-3-yl)-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carbothioamide
-
-
4-methyl-3-(5-methyl-2-phenyl-1H-indol-3-yl)-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carboxamide
-
-
4-methyl-3-(pyridin-4-yl)-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carbothioamide
-
-
4-methyl-3-(pyridin-4-yl)-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carboxamide
-
-
6,7-dichloro-3-(4-methyl-2-phenyl-2,3,3a,6-tetrahydropyrazolo[3,4-c]pyrazol-3-yl)-2-phenyl-1H-indole
-
-
Ca2+
-
40% inactivation at 2 mM; inhibition at 2 mM
Cu2+
-
10 mM, in presence of 2.5 mM Mg2+, 10% inhibition
Hg2+
-
10 mM, in presence of 2.5 mM Mg2+, 30% inhibition
iodoacetate
-
-
isocitrate
-
-
Itaconic acid
-
itaconic acid specifically inhibits growth of wild-type cells on acetate and propionate, but not dextrose, in an ICL-dependent manner, and elicited metabolomic changes similar to those observed with ICL-deficient cells. Enzyme ICL inhibition by itaconic acid results in a specific decrease in intrabacterial pH from pH 7.3 to pH 6.4 in propionat-grown cells, not in acetate-grown cells
NADH
-
noncompetitive
NADPH
-
noncompetitive
p-chloromercuribenzoate
-
-
Pb2+
-
10 mM, in presence of 2.5 mM Mg2+, 14% inhibition. 11% activation, when added instead of Mg2+
sulfhydryl reagents
-
-
Zn2+
-
10 mM, in presence of 2.5 mM Mg2+, 34% inhibition