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4.1.3.30: Methylisocitrate lyase

This is an abbreviated version!
For detailed information about Methylisocitrate lyase, go to the full flat file.

Word Map on EC 4.1.3.30

Reaction

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate
=
succinate
+
pyruvate

Synonyms

2-Methylisocitrate lyase, Lyase, methylisocitrate, MCL, Mcl1, methylisocitrate lyase, MICL, mmgF, PrpB, TgPrpB, yqiQ

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.30 Methylisocitrate lyase

Engineering

Engineering on EC 4.1.3.30 - Methylisocitrate lyase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L521F
-
L521 contributes to substrate specificity
L521F/S523T
-
L521 and S523 contribute to substrate specificity
S523T
-
S523 contributes to substrate specificity
L521F
-
L521 contributes to substrate specificity
-
L521F/S523T
-
L521 and S523 contribute to substrate specificity
-
S523T
-
S523 contributes to substrate specificity
-
C123S
-
the mutation has a significant effect on its mechanism in terms of both rate and stereochemistry
C123A
-
no enzyme activity
D58A
-
no enzyme activity
H125A
-
decreased kcat
K121A
-
decreased kcat
R122K
-
decreased kcat
additional information