4.1.3.3: N-acetylneuraminate lyase

This is an abbreviated version!
For detailed information about N-acetylneuraminate lyase, go to the full flat file.

Reaction

Synonyms

Acetylneuraminate pyruvate-lyase, class I NAL, EcNanA, Lyase, acetylneuraminate, N-acetyl-d-neuraminic acid aldolase, N-acetyl-D-neuraminic acid lyase, N-Acetylneuraminate aldolase, N-Acetylneuraminate lyase, N-acetylneuraminate pyruvate lyase, N-Acetylneuraminate pyruvate-lyase, N-Acetylneuraminic acid aldolase, N-Acetylneuraminic acid lyase, N-Acetylneuraminic aldolase, N-Acetylneuraminic lyase, NAL, NALase, NanA, NANA lyase, Neu5Ac aldolase, Neu5Ac lyase, NeuAc aldolase, NeuAc lyase, Neuraminate aldolase, Neuraminic acid aldolase, Neuraminic aldolase, NPL, PmNanA, sialate aldolase, Sialate lyase, sialate-pyruvate lyase, Sialic acid aldolase, Sialic aldolase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.3 N-acetylneuraminate lyase

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Results	in table
4	Activating Compound
2595	AA Sequence
14	Application
1	CAS Registry Number
31	Cloned(Commentary)
12	Crystallization (Commentary)
16	Disease/ Diagnostics
4	Expression
6	General Information
3	General Stability
92	Inhibitors
57	kcat/KM [mM/s]
5	Ki Value [mM]
160	KM Value [mM]
3	Localization
14	Metals/Ions
36	Molecular Weight [Da]
34	Natural Substrates/ Products (Substrates)
132	Organism
3	Oxidation Stability
6	Pathway
213	PDB ID
35	pH Optimum
9	pH Range
6	pH Stability
3	pI Value
105	Protein Variants
37	Purification (Commentary)
8	Reaction
8	Reaction Type
91	Reference
1	Renatured (Commentary)
16	Source Tissue
29	Specific Activity [micromol/min/mg]
1	Storage Stability
186	Substrates and Products (Substrate)
31	Subunits
96	Synonyms
1	Systematic Name
31	Temperature Optimum [°C]
2	Temperature Range [°C]
32	Temperature Stability [°C]
111	Turnover Number [1/s]

pH Stability

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pH Stability on EC 4.1.3.3 - N-acetylneuraminate lyase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 10

Staphylococcus hominis

-

purified recombinant enzyme, 24 h, 4°C, different buffers, over 70% activity remains

727332

6 - 7

Escherichia coli

-

at 75°C stable for more than 15 min

33332

6 - 8

Mycoplasma sp.

A0A2P1G7E2

the enzyme maintains around 95% residual cleavage activity after 120 min incubation at pH 6.0, and 85% residual cleavage activity after 120 min incubation at pH 8.0

748534

6 - 9

Escherichia coli

-

at 37°C stable for 24 h

33314

6.5 - 11

Lactiplantibacillus plantarum

-

about 80% activity (synthesis of N-acetylneuraminic acid) after 15 days at pH 8.0-10.0 and 37°C, 60% activity (synthesis of N-acetylneuraminic acid) after 15 days at pH 11.0 and 37°C

713843

7 - 10.5

Escherichia coli

-

spore-displayed N-acetyl-D-neuraminic acid aldolase is stable for 24 hours at 50°C

713852