4.1.3.3: N-acetylneuraminate lyase
This is an abbreviated version!
For detailed information about N-acetylneuraminate lyase, go to the full flat file.
Word Map on EC 4.1.3.3
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4.1.3.3
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mannac
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2-epimerase
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n-acetylmannosamine
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aldolases
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n-glycolylneuraminic
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cmp-sialic
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dihydrodipicolinate
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3.2.1.18
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biotechnology
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neu5gc
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dhdps
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synthesis
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n-acylneuraminate
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analysis
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industry
- 4.1.3.3
- mannac
-
2-epimerase
- n-acetylmannosamine
- aldolases
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n-glycolylneuraminic
-
cmp-sialic
- dihydrodipicolinate
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3.2.1.18
- biotechnology
- neu5gc
- dhdps
- synthesis
- n-acylneuraminate
- analysis
- industry
Reaction
Synonyms
Acetylneuraminate pyruvate-lyase, class I NAL, EcNanA, Lyase, acetylneuraminate, N-acetyl-d-neuraminic acid aldolase, N-acetyl-D-neuraminic acid lyase, N-Acetylneuraminate aldolase, N-Acetylneuraminate lyase, N-acetylneuraminate pyruvate lyase, N-Acetylneuraminate pyruvate-lyase, N-Acetylneuraminic acid aldolase, N-Acetylneuraminic acid lyase, N-Acetylneuraminic aldolase, N-Acetylneuraminic lyase, NAL, NALase, NanA, NANA lyase, Neu5Ac aldolase, Neu5Ac lyase, NeuAc aldolase, NeuAc lyase, Neuraminate aldolase, Neuraminic acid aldolase, Neuraminic aldolase, NPL, PmNanA, sialate aldolase, Sialate lyase, sialate-pyruvate lyase, Sialic acid aldolase, Sialic aldolase
ECTree
4.1.3.3 N-acetylneuraminate lyaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 4.1.3.3 - N-acetylneuraminate lyase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
CTAB
about 30% residual activity at 5 mM and pH 7.5 for N-acetylneuraminate synthesis and almost complete inhibition at 5 mM for N-acetylneuraminate cleavage
hydrogen peroxide
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0% residual activity at 10 mM, 16% residual activity at 1 mM
L-lysine
50% inhibition at 0.2 mM, inhibits wild-type enzyme, but not mutant enzymes
Bromopyruvate
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50% residual activity after incubation for 4.2 min with 1 mM bromopyruvate at pH 7.2, 37°C
N-bromosuccinimide
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0% residual activity at 0.01 mM, 36% residual activity at 0.001 mM
N-bromosuccinimide
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0% residual activity at 0.1 mM, 36% residual activity at 0.01 mM
p-chloromercuribenzoate
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0% residual activity at 0.1 mM, 9% residual activity at 0.01 mM
p-chloromercuribenzoate
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0% residual activity at 0.01 mM, 44% residual activity at 0.001 mM
SDS
about 30% residual activity at 5 mM and pH 7.5 for N-acetylneuraminate synthesis and almost complete inhibition at 5 mM for N-acetylneuraminate cleavage
Zn2+
about 25% residual activity at 5 mM and pH 7.5 for N-acetylneuraminate synthesis and almost complete inhibition at 5 mM and pH 7.5 for N-acetylneuraminate cleavage
