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4.1.3.24: malyl-CoA lyase

This is an abbreviated version!
For detailed information about malyl-CoA lyase, go to the full flat file.

Word Map on EC 4.1.3.24

Reaction

(2R,3S)-2-methylmalyl-CoA
=
propanoyl-CoA
+
glyoxylate

Synonyms

(3S)-malyl-CoA lyase, (3S)-malyl-coenzyme A lyase, L-malyl-CoA lyase/beta-methylmalyl-CoA lyase, L-malyl-CoA/beta-methylmalyl-CoA lyase, L-malyl-coenzyme A/beta-methylmalyl-coenzyme A lyase, lyase, malyl coenzyme A, malyl coenzyme A lyase, malyl-CoA lyase, malyl-CoA/beta-methylmalyl-CoA lyase, malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase, MCL, Mcl1, MCLC, MCLR

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.24 malyl-CoA lyase

Inhibitors

Inhibitors on EC 4.1.3.24 - malyl-CoA lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R)-4-malyl-CoA
acetyl-CoA
Ca2+
14% specific activity at 10 mM
Co2+
13% specific activity at 10 mM
glycolate
-
in direction of malyl-CoA synthesis: competitive with respect to glyoxylate and noncompetitive with respect to acetyl-CoA.In direction of malyl-CoA cleavage: competitive with respect to malyl-CoA
Ni2+
6% specific activity at 10 mM
oxalate
oxylate
-
in direction of malyl-CoA cleavage: competitive with respect to malyl-CoA
propionyl-CoA
-
in direction of malyl-CoA synthesis: uncompetitive with respect to glyoxylate and competitive with respect to acetyl-CoA. In direction of malyl-CoA cleavage: noncompetitive with respect to malyl-CoA
succinate
activity is downregulated 10fold