4.1.3.1: isocitrate lyase
This is an abbreviated version!
For detailed information about isocitrate lyase, go to the full flat file.
Word Map on EC 4.1.3.1
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4.1.3.1
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interstrand
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malate
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lens
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eyes
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collamer
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postoperative
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intraocular
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crosslinks
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refract
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preoperative
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phakic
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acuity
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fanconi
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anemia
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posterior
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spherical
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uncorrected
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myopic
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vault
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fork
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diopter
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corneal
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astigmatism
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glyoxysomal
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fancd2
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pupil
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lymphocytopenia
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translesion
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logmar
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itaconate
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anaplerotic
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monoubiquitination
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psoralens
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monoadducts
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gaba-induced
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vision-threatening
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pupillary
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incisions
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hyperopic
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keratomileusis
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subcapsular
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lasik
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microbodies
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biomicroscopy
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drug development
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snellen
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medicine
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as-oct
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best-corrected
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sn-glycerol-3-phosphate
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spectacle
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molecular biology
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gelatinosa
- 4.1.3.1
-
interstrand
- malate
- lens
- eyes
-
collamer
-
postoperative
-
intraocular
-
crosslinks
-
refract
-
preoperative
-
phakic
-
acuity
-
fanconi
- anemia
-
posterior
-
spherical
-
uncorrected
-
myopic
-
vault
-
fork
-
diopter
- corneal
- astigmatism
- glyoxysomal
-
fancd2
- pupil
- lymphocytopenia
-
translesion
-
logmar
- itaconate
-
anaplerotic
-
monoubiquitination
- psoralens
-
monoadducts
-
gaba-induced
-
vision-threatening
-
pupillary
-
incisions
-
hyperopic
-
keratomileusis
-
subcapsular
-
lasik
- microbodies
-
biomicroscopy
- drug development
-
snellen
- medicine
-
as-oct
-
best-corrected
- sn-glycerol-3-phosphate
-
spectacle
- molecular biology
- gelatinosa
Reaction
Synonyms
AceA, acuD, citrate lyase, D-threo-isocitrate: glyoxylate lyase, EgGCE, FPICL1, ICL, ICL1, ICL2, isocitrase, isocitratase, isocitrate lyase, isocitrate lyase 1, isocitrate lyase 2, isocitric lyase, isocitritase, lyase, isocitrate, MtbIcl, PDP, petal death protein, SSO1333, threo-DS-Isocitrate glyoxylate-lyase
ECTree
4.1.3.1 isocitrate lyaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.1.3.1 - isocitrate lyase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate
succinate + glyoxylate
-
reversible aldol cleavage
glyoxylate shunt
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r
(2R)-ethyl-(3S)-methyl malate
2-oxobutanoate + propanoate
-
-
-
?
(2R)-isobutyl-(3S)-methyl malate
4-methyl-2-oxopentanoate + propanoate
-
-
-
?
(2R)-propyl-(3S)-methyl malate
4-methyl-2-oxopentanoate + propanoate
-
-
-
?
(2R,3S:2S,3R)-2-methyl-isocitrate
succinate + pyruvate
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-
-
?
(2R,3S:2S,3R)-2-methyl-isocitrate
succinate + pyruvate
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-
-
?
isocitrate
?
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assimilation of one-carbon compounds in the icl+ serine pathway
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-
?
isocitrate
glyoxylate + succinate
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blue-native SDS-PAGE
coupling glyoxylate formation to lactate dehydrogenase type II activity (10 U) in presence of NAD+
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?
isocitrate
succinate + glyoxylate
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pH 7.3, cell-free extracts, in presence of MgCl2 and 2,4-dinitrophenylhydrazine
analysis based on absorbance at 450 nm
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?
isocitrate
succinate + glyoxylate
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pH 7.3, cell-free extracts, in presence of MgCl2 and 2,4-dinitrophenylhydrazine
analysis based on absorbance at 450 nm
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?
isocitrate
succinate + glyoxylate
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first step in glyoxylate-bypass pathway
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?
isocitrate
succinate + glyoxylate
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regulatory enzyme playing a crucial role in fungal growth
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?
isocitrate
succinate + glyoxylate
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key enzyme of the glyoxylate cycle
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-
?
isocitrate
succinate + glyoxylate
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key enzyme of the glyoxylate cycle
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-
?
isocitrate
succinate + glyoxylate
-
-
-
-
?
isocitrate
succinate + glyoxylate
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30°C, pH 7.5, HEPES containing phenylhydrazine HCl
absorbance of glyoxylate phenylhydrazone at 334 nm
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r
isocitrate
succinate + glyoxylate
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isotopic analysis, solvent kinetic isotope effects in the direction of isocitrate cleavage arise from the initial deprotonation of the C2 hydroxyl group of isocitrate or the protonation of the aci-acid of the succinate product of the isocitrate aldolcleavage by a solvent-derived proton, equilibrium perturbation in D2O, NMR spectroscopy and mass spectrometry, modeling, overview. The final equilibrium isotopic composition of reactants in D2O reveals dideuterated succinate, protiated glyoxylate, and monodeuterated isocitrate, with the transient appearance and disappearance of monodeuterated succinate
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-
r
isocitrate
succinate + glyoxylate
-
-
-
?
isocitrate
succinate + glyoxylate
-
rate-limiting enzyme of the citric acid cycle
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?
isocitrate
succinate + glyoxylate
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first enzyme of glyoxylate shunt
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?
threo-DL-isocitrate
succinate + glyoxylate
-
-
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?
additional information
?
-
-
Lys-193, Cys-195, His-197 and His-356 are catalytic, active-site residues, while His-184 is involved in the assembly of the tetrameric enzyme
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-
?
additional information
?
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-
Mycobacterium tuberculosis isocitrate lyases are catalytically bifunctional isocitrate and methylisocitrate lyases, EC 4.1.3.1 and EC 4.1.3.30, required for growth on even and odd chain fatty acids
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?
