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4.1.3.1: isocitrate lyase

This is an abbreviated version!
For detailed information about isocitrate lyase, go to the full flat file.

Word Map on EC 4.1.3.1

Reaction

isocitrate
=
succinate
 +
glyoxylate

Synonyms

AceA, acuD, citrate lyase, D-threo-isocitrate: glyoxylate lyase, EgGCE, FPICL1, ICL, ICL1, ICL2, isocitrase, isocitratase, isocitrate lyase, isocitrate lyase 1, isocitrate lyase 2, isocitric lyase, isocitritase, lyase, isocitrate, MtbIcl, PDP, petal death protein, SSO1333, threo-DS-Isocitrate glyoxylate-lyase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.1 isocitrate lyase

Specific Activity

Specific Activity on EC 4.1.3.1 - isocitrate lyase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.002
-
knock-out mutant enzyme after growth on gluconate, crude extract
0.0029
-
in cell-free extracts after cell growth in YPD medium
0.003
-
knock-out mutant enzyme after growth on gluconate + heptanoate, crude extract
0.004
0.0048
-
in cell-free extracts after cell growth in YPD medium containing 1 M NaCl
0.005
-
in cell-free extracts after cell growth in YPD medium containing 1 M KCl
0.011
-
control cells, pH 7.3
0.022
-
strain BW3709, 0.2% glucose (batch)
0.023
-
strain BW3767, 0.2% glucose (batch)
0.024
-
isoform ICL2, at pH 6.5 and 25°C
0.03
-
isoform ICL1, with 5 mM MnCl2, at pH 6.5 and 25°C
0.034
-
strain BW2952, 0.2% glucose (batch)
0.035
-
isoform ICL2, with 5 mM MnCl2, at pH 6.5 and 25°C
0.04
-
homogenate
0.043
-
wild-type enzyme after growth on gluconate, crude extract
0.053
-
Al-stressed cells, pH 7.3
0.088
-
strain BW3480, 0.02% glucose (chemostat)
0.138
0.155
-
strain MG1655, 0.2% glucose (batch)
0.19
-
strain BW3708, 0.2% glucose (batch)
0.22
-
crude cell extract
0.248
-
strain BW2952, 0.02% glucose (chemostat)
0.321
-
wild-type enzyme after growth on gluconate + heptanoate, crude extract
0.471
-
strain BW3767, 0.02% glucose (chemostat)
0.48
-
isoform ICL1, at pH 6.5 and 25°C
0.538
-
strain BW3709, 0.02% glucose (chemostat)
0.586
37°C, wild type
0.636
isocitrate lyase activity
1.066
-
strain BW2952, 0.2% acetate (batch)
1.227
-
strain BW3767, 0.2% acetate (batch)
1.656
-
strain BW3709, 0.2% acetate (batch)
1.674
-
strain MG1655, 0.02% glucose (chemostat)
1.778
-
strain BW3708, 0.02% glucose (chemostat)
1.83
Lupinus sp.
-
-
10.1
-
-
10.5
-
mutant Q217K
14.5
-
mutant Q207H
14.6
-
wild-type
2.084
-
strain MG1655, 0.2% acetate (batch)
3.075
-
strain BW3708, 0.2% acetate (batch)
3.68
Lupinus sp.
-
-
3.85
pH and temperature not specified in the publication
4.4
-
ICL2, 1003fold purified
4.45
-
-
4.9
-
ICL1, 123fold purified
4.96
-
-
5.19
malate synthase activity
5.28
-
pH 7.5, 25°C
5.5
-
pH 7.5, 25°C
5.81
-
pH 7.5, 25°C
7.9
-
after 30fold purification
8.01
Candida brassicae
-
-
8.4
-
after 38.2fold purification
8.8 - 10.9
-
-
9.48
-
-
9.5
-
purified ICL
9.9 - 11
-
-
additional information