4.1.3.1: isocitrate lyase
This is an abbreviated version!
For detailed information about isocitrate lyase, go to the full flat file.
Word Map on EC 4.1.3.1
-
4.1.3.1
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interstrand
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malate
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lens
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eyes
-
collamer
-
postoperative
-
intraocular
-
crosslinks
-
refract
-
preoperative
-
phakic
-
acuity
-
fanconi
-
anemia
-
posterior
-
spherical
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uncorrected
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myopic
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vault
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fork
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diopter
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corneal
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astigmatism
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glyoxysomal
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fancd2
-
pupil
-
lymphocytopenia
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translesion
-
logmar
-
itaconate
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anaplerotic
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monoubiquitination
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psoralens
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monoadducts
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gaba-induced
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vision-threatening
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pupillary
-
incisions
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hyperopic
-
keratomileusis
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subcapsular
-
lasik
-
microbodies
-
biomicroscopy
-
drug development
-
snellen
-
medicine
-
as-oct
-
best-corrected
-
sn-glycerol-3-phosphate
-
spectacle
-
molecular biology
-
gelatinosa
- 4.1.3.1
-
interstrand
- malate
- lens
- eyes
-
collamer
-
postoperative
-
intraocular
-
crosslinks
-
refract
-
preoperative
-
phakic
-
acuity
-
fanconi
- anemia
-
posterior
-
spherical
-
uncorrected
-
myopic
-
vault
-
fork
-
diopter
- corneal
- astigmatism
- glyoxysomal
-
fancd2
- pupil
- lymphocytopenia
-
translesion
-
logmar
- itaconate
-
anaplerotic
-
monoubiquitination
- psoralens
-
monoadducts
-
gaba-induced
-
vision-threatening
-
pupillary
-
incisions
-
hyperopic
-
keratomileusis
-
subcapsular
-
lasik
- microbodies
-
biomicroscopy
- drug development
-
snellen
- medicine
-
as-oct
-
best-corrected
- sn-glycerol-3-phosphate
-
spectacle
- molecular biology
- gelatinosa
Reaction
Synonyms
AceA, acuD, citrate lyase, D-threo-isocitrate: glyoxylate lyase, EgGCE, FPICL1, ICL, ICL1, ICL2, isocitrase, isocitratase, isocitrate lyase, isocitrate lyase 1, isocitrate lyase 2, isocitric lyase, isocitritase, lyase, isocitrate, MtbIcl, PDP, petal death protein, SSO1333, threo-DS-Isocitrate glyoxylate-lyase
ECTree
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IC50 Value
IC50 Value on EC 4.1.3.1 - isocitrate lyase
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0.0126
(1R,2R,6E)-8-(2,5-dihydroxyphenyl)-2-hydroxy-6-methyl-1-[[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl]oct-6-en-1-yl hydrogen sulfate
Pyricularia grisea
-
-
0.01561
(2-bromo-4,5-dihydroxybenzyl)(2,3-dibromo-4,5-dihydroxybenzyl) ether
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.06819
(2-bromo-4,5-dihydroxyphenyl)(3,4-dihydroxyphenyl) ether
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.185
(2E,6E)-9-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2,6-dimethylnona-2,6-dienal
Candida albicans
-
pH 7.0, 37°C
0.1729
(2E,7E)-10-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-3,7-dimethyl-2-(2-methylprop-1-en-1-yl)deca-2,7-dienal
Candida albicans
-
pH 7.0, 37°C
0.1184
(2R)-2-[(3E,7E)-9-(hydroxymethyl)-4,8,11-trimethyldodeca-3,7,10-trien-1-yl]-2,8-dimethyl-3,4-dihydro-2H-chromen-6-ol
Candida albicans
-
pH 7.0, 37°C
0.00265
(3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5-dihydroxyphenyl)methanone
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.141
(4R,5R)-4-[(2E)-5-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2-methylpent-2-en-1-yl]-2-methyl-5-(2-methylprop-1-en-1-yl)cyclopent-2-en-1-one
Candida albicans
-
pH 7.0, 37°C
0.01716
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(4-methoxybenzylidene)furan-2(5H)-one
Candida albicans
pH and temperature not specified in the publication
0.00762
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)furan-2(5H)-one
Candida albicans
pH and temperature not specified in the publication
0.0488
(5Z)-5-(3-bromo-4-hydroxybenzylidene)-4-(3-bromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]furan-2(5H)-one
Candida albicans
pH and temperature not specified in the publication
0.089
1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.301
1-(2-aminoethyl)-1H-indol-6-ol
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.075
1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.0126
1-(4-ethylpiperazin-1-yl)-3-nitropropan-1-one
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.18
1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.137
1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-b-carboline
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.00012
1-cyclopropyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.0001
1-cyclopropyl-7-(3,5-dimethyl-4-(3-nitropropanoyl)piperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.0001
1-cyclopropyl-7-[3,5-dimethyl-4-(3-nitropropanoyl)piperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.00146
1-ethyl-6,8-difluoro-7-[3-methyl-4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.0002
1-ethyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.002
2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane
Pyricularia grisea
-
in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C
0.0028
2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-hydroxymethyldiphenylmethane
Pyricularia grisea
-
in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C
0.01477
2,2',3-tribromo-4,4',5,5'-tetrahydroxybibenzyl
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.02121
2,2'-dibromo-4,4',5,5'-tetrahydroxybibenzyl
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.0926
2,3-dibromo-4,5-dihydroxybenzyl alcohol
Pyricularia grisea
-
in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C
0.1256
2,3-dibromo-4,5-dihydroxybenzyl methyl ether
Pyricularia grisea
-
in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C
0.318
2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.015
2-[(2E,7R,8R)-7,8-dihydroxy-3-methyl-9-[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]non-2-en-1-yl]benzene-1,4-diol
Pyricularia grisea
-
-
0.0929
3,4-dihydrohyrtiosulawesine
Candida albicans
-
pH and temperature not specified in the publication
0.116
3,5-dibromo-4-hydroxyphenylethylamine
Pyricularia grisea
-
in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C
0.0021
3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethylpyrocatechol
Pyricularia grisea
-
in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C
0.04121
3-nitro-1-(4-phenylpiperazin-1-yl)propan-1-one
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.03018
3-nitro-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.116
3-nitropropionic acid
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.02806
4,4'-(oxydimethanediyl)bis(5,6-dibromobenzene-1,2-diol)
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.05847
4,4'-ethane-1,2-diyldibenzene-1,2-diol
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.01844
4,4'-methanediylbis(5,6-dibromobenzene-1,2-diol)
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.04615
4,4'-methanediylbis(5-bromobenzene-1,2-diol)
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.0039
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00314
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.02537
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00574
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.01152
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00316
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00734
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00511
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.08702
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00849
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00491
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00369
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.01543
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00586
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00298
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00372
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.0513
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00445
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.0086
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.247
5-hydroxy-1H-indole-3-carbaldehyde
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.38
6-hydroxy-4,9-dihydro-3H-beta-carboline-1-carboxylic acid
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.01163
bis(2,3-dibromo-4,5-dihydroxyphenyl) ether
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.03088
bis(2-bromo-4,5-dihydroxyphenyl) ether
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.02258
bis(3,4-dihydroxyphenyl)methanone
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.00889
bis(3-bromo-4,5-dihydroxyphenyl)methanone
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.07517
dimethyl (2Z)-2-(3,5-dibromo-4-hydroxybenzoyl)-3-(3,5-dibromo-4-hydroxyphenyl)but-2-enedioate
Candida albicans
pH and temperature not specified in the publication
0.1216
dimethyl (2Z)-2-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)but-2-enedioate
Candida albicans
pH and temperature not specified in the publication
0.0033
itaconic anhydride
Mycobacterium tuberculosis
-
in 50 mM potassium phosphate, 4 mM MgCl2, 4 mM phenylhydrazine, 12 mM cysteine, pH 7.0, at 37°C
0.01036
methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate
Candida albicans
pH and temperature not specified in the publication
0.04662
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00388
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00798
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.0076
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.0368
N-(4-bromo-3-methylphenyl)-3-nitropropanamide
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.03246
N-(4-bromophenyl)-3-nitropropanamide
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.02132
N-(4-chlorophenyl)-3-nitropropanamide
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.00563
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00653
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00409
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.00874
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
Mycobacterium tuberculosis
-
pH 7.0, 37°C
0.0674
sodium (2S)-5-furan-3-yl-2-[(1R)-1-hydroxy-2-[(1S,2R,4aR,8aR)-2-methyl-5-methylidenedecahydronaphthalen-1-yl]ethyl]pentyl sulfate
Pyricularia grisea
-
-
5
succinate
Aspergillus fumigatus
-
in 50 mM MOPS buffer, pH 7.5, with 1 mM MgCl2, 10 mM 2-mercaptoethanol, and 2.7 mM O-nitrophenyl-beta-D-galactopyranoside
0.0477
XHD-1
Mycobacterium tuberculosis
-
in 50 mM potassium phosphate, 4 mM MgCl2, 4 mM phenylhydrazine, 12 mM cysteine, pH 7.0, at 37°C
-
0.0182
XHD-2
Mycobacterium tuberculosis
-
in 50 mM potassium phosphate, 4 mM MgCl2, 4 mM phenylhydrazine, 12 mM cysteine, pH 7.0, at 37°C
-
additional information
(4S,5bR,11aS,13aS,13bR)-4-hydroxy-5b,8,8,11a,13a-pentamethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
0.00166
Candida albicans
pH and temperature not specified in the publication
0.0507
3-nitropropionate
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.051
3-nitropropionate
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.0924
3-nitropropionate
Pyricularia grisea
-
in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C
additional information
(4S,5bR,11aS,13aS,13bR)-4-hydroxy-5b,8,8,11a,13a-pentamethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
Candida albicans
-
> 0.1 mg/ml
additional information
(4S,5bS,11aR,13aS,13bR)-11a-formyl-4-hydroxy-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
Candida albicans
-
> 0.1 mg/ml
additional information
(4S,5bS,11aR,13aS,13bR)-11a-[(acetyloxy)methyl]-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1,4-diyl diacetate
Candida albicans
-
> 0.1 mg/ml
additional information
(5bS,11aR,13aS,13bR)-11a-(hydroxymethyl)-5b,8,8,13a-tetramethyl-3-oxo-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
Candida albicans
-
> 0.1 mg/ml
additional information
(5E)-5-[(2R,6E,10E)-13-furan-3-yl-2,6,10-trimethyltrideca-6,10-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
Candida albicans
-
0.027 mg/ml
additional information
(5Z)-5-[(2R,5Z,9Z)-13-furan-3-yl-2,6,10-trimethyltrideca-5,9-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
Candida albicans
-
0.0312 mg/ml
additional information
12-deacetoxy-23-acetoxy-19-O-acetylscalarin
Candida albicans
-
> 0.1 mg/ml
additional information
methyl (1R,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
Candida albicans
-
0.055 mg/ml
additional information
methyl (1S,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
Candida albicans
-
> 0.1 mg/ml
additional information
[(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methanol
Candida albicans
-
0.0457 mg/ml
additional information
[(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methyl acetate
Candida albicans
-
> 0.1 mg/ml
additional information
[(5bS,11aR,13aS,13bR)-1-methoxy-5b,8,8,13a-tetramethyl-1,5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a,13b-hexadecahydrochryseno[1,2-c]furan-11a(3H)-yl]methanol
Candida albicans
-
0.042 mg/ml