4.1.3.1: isocitrate lyase

This is an abbreviated version!
For detailed information about isocitrate lyase, go to the full flat file.

Word Map on EC 4.1.3.1

4.1.3.1

interstrand

malate

lens

eyes

collamer

postoperative

intraocular

crosslinks

refract

preoperative

phakic

acuity

fanconi

anemia

posterior

spherical

uncorrected

myopic

vault

fork

diopter

corneal

astigmatism

glyoxysomal

fancd2

pupil

lymphocytopenia

translesion

logmar

itaconate

anaplerotic

monoubiquitination

psoralens

monoadducts

gaba-induced

vision-threatening

pupillary

incisions

hyperopic

keratomileusis

subcapsular

lasik

microbodies

biomicroscopy

drug development

snellen

medicine

as-oct

best-corrected

sn-glycerol-3-phosphate

spectacle

molecular biology

gelatinosa

Reaction

Synonyms

AceA, acuD, citrate lyase, D-threo-isocitrate: glyoxylate lyase, EgGCE, FPICL1, ICL, ICL1, ICL2, isocitrase, isocitratase, isocitrate lyase, isocitrate lyase 1, isocitrate lyase 2, isocitric lyase, isocitritase, lyase, isocitrate, MtbIcl, PDP, petal death protein, SSO1333, threo-DS-Isocitrate glyoxylate-lyase

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.3 Oxo-acid-lyases

4.1.3.1 isocitrate lyase

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Results	in table
42	Activating Compound
16957	AA Sequence
15	Application
1	CAS Registry Number
45	Cloned(Commentary)
8	Crystallization (Commentary)
19	Expression
61	General Information
4	General Stability
120	IC50 Value
523	Inhibitors
5	kcat/KM [mM/s]
24	Ki Value [mM]
130	KM Value [mM]
18	Localization
95	Metals/Ions
114	Molecular Weight [Da]
98	Natural Substrates/ Products (Substrates)
822	Organism
3	Oxidation Stability
7	Pathway
118	PDB ID
56	pH Optimum
8	pH Range
4	pH Stability
3	pI Value
4	Posttranslational Modification
63	Protein Variants
72	Purification (Commentary)
4	Reaction
2	Reaction Type
210	Reference
59	Source Tissue
80	Specific Activity [micromol/min/mg]
31	Storage Stability
235	Substrates and Products (Substrate)
72	Subunits
208	Synonyms
1	Systematic Name
27	Temperature Optimum [°C]
4	Temperature Range [°C]
37	Temperature Stability [°C]
31	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 4.1.3.1 - isocitrate lyase

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0.0126

(1R,2R,6E)-8-(2,5-dihydroxyphenyl)-2-hydroxy-6-methyl-1-[[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl]oct-6-en-1-yl hydrogen sulfate

Pyricularia grisea

678657

0.01561

(2-bromo-4,5-dihydroxybenzyl)(2,3-dibromo-4,5-dihydroxybenzyl) ether

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.06819

(2-bromo-4,5-dihydroxyphenyl)(3,4-dihydroxyphenyl) ether

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.185

(2E,6E)-9-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2,6-dimethylnona-2,6-dienal

Candida albicans

pH 7.0, 37°C

714425

0.1729

(2E,7E)-10-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-3,7-dimethyl-2-(2-methylprop-1-en-1-yl)deca-2,7-dienal

Candida albicans

pH 7.0, 37°C

714425

0.1184

(2R)-2-[(3E,7E)-9-(hydroxymethyl)-4,8,11-trimethyldodeca-3,7,10-trien-1-yl]-2,8-dimethyl-3,4-dihydro-2H-chromen-6-ol

Candida albicans

pH 7.0, 37°C

714425

0.00265

(3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5-dihydroxyphenyl)methanone

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.141

(4R,5R)-4-[(2E)-5-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2-methylpent-2-en-1-yl]-2-methyl-5-(2-methylprop-1-en-1-yl)cyclopent-2-en-1-one

Candida albicans

pH 7.0, 37°C

714425

0.01716

(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(4-methoxybenzylidene)furan-2(5H)-one

Candida albicans

Q9P8Q7

pH and temperature not specified in the publication

727150

0.00762

(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)furan-2(5H)-one

Candida albicans

Q9P8Q7

pH and temperature not specified in the publication

727150

0.0488

(5Z)-5-(3-bromo-4-hydroxybenzylidene)-4-(3-bromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]furan-2(5H)-one

Candida albicans

Q9P8Q7

pH and temperature not specified in the publication

727150

0.4

(E)-2-(3-methylnon-2-enyl)benzene-1,4-diol

Candida albicans

677867

0.29

(E)-2-(4-hydroxy-3-methylbut-2-enyl)benzene-1,4-diol

Candida albicans

677867

0.28

(E)-2-(9-hydroxy-3-methylnon-2-enyl)benzene-1,4-diol

Candida albicans

677867

0.089

1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714420

0.301

1-(2-aminoethyl)-1H-indol-6-ol

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714420

0.075

1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714420

0.0126

1-(4-ethylpiperazin-1-yl)-3-nitropropan-1-one

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.18

1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714420

0.137

1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-b-carboline

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714420

0.379

1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline

Candida albicans

0.874 mg/ml

696655

0.00012

1-cyclopropyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.0001

1-cyclopropyl-7-(3,5-dimethyl-4-(3-nitropropanoyl)piperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.0001

1-cyclopropyl-7-[3,5-dimethyl-4-(3-nitropropanoyl)piperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Mycobacterium tuberculosis

pH and temperature not specified in the publication

727341

0.00146

1-ethyl-6,8-difluoro-7-[3-methyl-4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.0002

1-ethyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.002

2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane

Pyricularia grisea

in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C

680310

0.0028

2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-hydroxymethyldiphenylmethane

Pyricularia grisea

in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C

680310

0.01477

2,2',3-tribromo-4,4',5,5'-tetrahydroxybibenzyl

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.02121

2,2'-dibromo-4,4',5,5'-tetrahydroxybibenzyl

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.0926

2,3-dibromo-4,5-dihydroxybenzyl alcohol

Pyricularia grisea

in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C

680310

0.1256

2,3-dibromo-4,5-dihydroxybenzyl methyl ether

Pyricularia grisea

in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C

680310

0.61

2-(3-methylbut-2-enyl)benzene-1,4-diol

Candida albicans

677867

1.02

2-allylbenzene-1,4-diol

Candida albicans

677867

0.318

2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714420

0.015

2-[(2E,7R,8R)-7,8-dihydroxy-3-methyl-9-[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]non-2-en-1-yl]benzene-1,4-diol

Pyricularia grisea

678657

0.0929

3,4-dihydrohyrtiosulawesine

Candida albicans

pH and temperature not specified in the publication

748756

0.116

3,5-dibromo-4-hydroxyphenylethylamine

Pyricularia grisea

in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C

680310

0.0021

3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethylpyrocatechol

Pyricularia grisea

in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C

680310

0.04121

3-nitro-1-(4-phenylpiperazin-1-yl)propan-1-one

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.03018

3-nitro-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.00166 - 0.0924

3-nitropropionate

6 entries

0.116

3-nitropropionic acid

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.02806

4,4'-(oxydimethanediyl)bis(5,6-dibromobenzene-1,2-diol)

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.05847

4,4'-ethane-1,2-diyldibenzene-1,2-diol

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.01844

4,4'-methanediylbis(5,6-dibromobenzene-1,2-diol)

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.04615

4,4'-methanediylbis(5-bromobenzene-1,2-diol)

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.0039

4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00314

4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.02537

4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00574

4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.01152

4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00316

4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00734

4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00511

4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.08702

4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00849

4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00491

5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00369

5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.01543

5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00586

5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00298

5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00372

5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.0513

5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00445

5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.0086

5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.247

5-hydroxy-1H-indole-3-carbaldehyde

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714420

0.799

5-hydroxy-1H-indole-3-carboxylic acid methyl ester

Candida albicans

0.153 mg/ml

696655

0.247

5-hydroxyindole-3-carbaldehyde

Candida albicans

0.0398 mg/ml

696655

0.38

6-hydroxy-4,9-dihydro-3H-beta-carboline-1-carboxylic acid

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714420

0.01163

bis(2,3-dibromo-4,5-dihydroxyphenyl) ether

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.03088

bis(2-bromo-4,5-dihydroxyphenyl) ether

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.02258

bis(3,4-dihydroxyphenyl)methanone

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.00889

bis(3-bromo-4,5-dihydroxyphenyl)methanone

Candida albicans

pH not specified in the publication, temperature not specified in the publication

714419

0.6

CdCl2

Mycobacterium tuberculosis

701127

0.07517

dimethyl (2Z)-2-(3,5-dibromo-4-hydroxybenzoyl)-3-(3,5-dibromo-4-hydroxyphenyl)but-2-enedioate

Candida albicans

Q9P8Q7

pH and temperature not specified in the publication

727150

0.1216

dimethyl (2Z)-2-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)but-2-enedioate

Candida albicans

Q9P8Q7

pH and temperature not specified in the publication

727150

0.318

hyrtiosin A

Candida albicans

0.061 mg/ml

696655

0.089

hyrtiosin B

Candida albicans

0.285 mg/ml

696655

0.06

Itaconate

Candida albicans

677867

0.0033

itaconic anhydride

Mycobacterium tuberculosis

in 50 mM potassium phosphate, 4 mM MgCl2, 4 mM phenylhydrazine, 12 mM cysteine, pH 7.0, at 37°C

679472

0.01036

methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate

Candida albicans

Q9P8Q7

pH and temperature not specified in the publication

727150

0.04662

N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00388

N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00798

N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.0076

N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.0368

N-(4-bromo-3-methylphenyl)-3-nitropropanamide

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.03246

N-(4-bromophenyl)-3-nitropropanamide

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.02132

N-(4-chlorophenyl)-3-nitropropanamide

Mycobacterium tuberculosis

pH not specified in the publication, temperature not specified in the publication

714444

0.00563

N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00653

N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00409

N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.00874

N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide

Mycobacterium tuberculosis

pH 7.0, 37°C

727419

0.301

serotonin

Candida albicans

0.053 mg/ml

696655

0.0674

sodium (2S)-5-furan-3-yl-2-[(1R)-1-hydroxy-2-[(1S,2R,4aR,8aR)-2-methyl-5-methylidenedecahydronaphthalen-1-yl]ethyl]pentyl sulfate

Pyricularia grisea

678657

succinate

Aspergillus fumigatus

in 50 mM MOPS buffer, pH 7.5, with 1 mM MgCl2, 10 mM 2-mercaptoethanol, and 2.7 mM O-nitrophenyl-beta-D-galactopyranoside

679978

0.0477

XHD-1

Mycobacterium tuberculosis

in 50 mM potassium phosphate, 4 mM MgCl2, 4 mM phenylhydrazine, 12 mM cysteine, pH 7.0, at 37°C

679472

0.0182

XHD-2

Mycobacterium tuberculosis

in 50 mM potassium phosphate, 4 mM MgCl2, 4 mM phenylhydrazine, 12 mM cysteine, pH 7.0, at 37°C

679472

0.8

ZnCl2

Mycobacterium tuberculosis

701127

additional information

(4S,5bR,11aS,13aS,13bR)-4-hydroxy-5b,8,8,11a,13a-pentamethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate

16 entries