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4.1.3.1: isocitrate lyase

This is an abbreviated version!
For detailed information about isocitrate lyase, go to the full flat file.

Word Map on EC 4.1.3.1

Reaction

isocitrate
=
succinate
 +
glyoxylate

Synonyms

AceA, acuD, citrate lyase, D-threo-isocitrate: glyoxylate lyase, EgGCE, FPICL1, ICL, ICL1, ICL2, isocitrase, isocitratase, isocitrate lyase, isocitrate lyase 1, isocitrate lyase 2, isocitric lyase, isocitritase, lyase, isocitrate, MtbIcl, PDP, petal death protein, SSO1333, threo-DS-Isocitrate glyoxylate-lyase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.1 isocitrate lyase

Expression

Expression on EC 4.1.3.1 - isocitrate lyase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Ca2+, K+, and Na+ have little effect on the regulation of activity of ICL isoforms
-
degradation of the aceA mRNA, encoding the enzyme, by RNase E/G, that cleaves the aceA mRNA at a single-stranded AU-rich region in the 3' untranslated region. The level of aceA mRNA is approximately 3fold higher in the rneG knockout mutant strain D2281 compared to the wild-type strain
during infection, significant ICL gene expression in conidia, appressoria, mycelia and hyphae
-
enzyme activity is induced under alternating day/night cycles
-
enzyme expression is induced by acetate
expressed in macrophages
-
ICL in a rabbit meningitis model is upregulated after 7 days in the subarachnoid space
-
in bloodstream infection, ICL is downregulated in the initial stages of infection (10 min)
-
in planta, ICL1 expression is continuously down-regulated upon germination. During the later stages of the infection of wheat, the level of ICL1 expression is extremely low
increased aceA (icl) mRNA expression in response to human macrophages. ICL mRNA levels markedly increase in lungs of mice and in human lung granulomas, as well as in the lymphocyte region of necrotic granulomas
-
induced during growth on acetate but not on xylose
is induced in Candida albicans exposed to human neutrophils. In bloodstream infection, ICL is upregulated beginning about 20 min after infection and reaches a 20fold increase after 60 min. ICL expression is detected during growth on Casamino acids, glutamate or peptone, and under starvation conditions
-
regulated by carbon sources
-
the highest isoform ICL1 activity is observed on the 3rd day of germination; then the activity and expression of the corresponding gene decreases, while the activity of isoform ICL2 and gene expression increases to the 7th day of germination and then remains at the same level
-
transcript level of the ICL gene increases following phagocytosis by murine macrophages. After macrophage internalization of conidia the ICL-encoding gene (acuD) is highly expressed
-