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4.1.2.27: sphinganine-1-phosphate aldolase

This is an abbreviated version!
For detailed information about sphinganine-1-phosphate aldolase, go to the full flat file.

Word Map on EC 4.1.2.27

Reaction

sphinganine 1-phosphate
=
Phosphoethanolamine
 +
palmitaldehyde

Synonyms

aldolase, dihydrosphingosine 1-phosphate, Dihydrosphingosine 1-phosphate aldolase, dihydrosphingosine phosphate lyase, Dpl1, Dpl1p, LegS2, S-1-P-lyase, S1P lyase, S1P-lyase, S1PL, S1PL2021, Sgpl1, sphinganine 1-phosphate lyase, sphinganine-1-phosphate aldolase, sphinganine-1-phosphate lyase, sphinganine-1-phosphate-alkanal-lyase, sphingosine 1-phosphate lyase, sphingosine phosphate lyase, sphingosine-1-phosphate lyase, sphingosine-phosphate lyase, SPL, SPL1

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.27 sphinganine-1-phosphate aldolase

Source Tissue

Source Tissue on EC 4.1.2.27 - sphinganine-1-phosphate aldolase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
CRL 1444 (ATCC)
Manually annotated by BRENDA team
-
high expression rate
Manually annotated by BRENDA team
-
circulating T lymphocyte
Manually annotated by BRENDA team
-
CRL 1443 (ATCC)
Manually annotated by BRENDA team
-
CRL 1772 (ATCC)
Manually annotated by BRENDA team
-
high expression rate
Manually annotated by BRENDA team
-
high expression rate
Manually annotated by BRENDA team
-
the cells expressing sphingosine-1-phosphate lyase in the parenchyma o lymph nodes are CD68+ antigen-presenting cells. CD68+ antigen-presenting cells generated from human monocytes are able to internalize and irreversibly degrade sphingosine 1-phosphate
Manually annotated by BRENDA team
-
high expression rate
Manually annotated by BRENDA team
-
embryonal carcinoma cell
Manually annotated by BRENDA team
-
weak expression
Manually annotated by BRENDA team
-
CCL2 (ATCC)
Manually annotated by BRENDA team
-
HB 8065 (ATTC)
Manually annotated by BRENDA team
-
inhibition of sphingosine-1-phosphate lyase activity rendes sphingosine 1-phosphate an efficient S1P1 receptor internalizing compound and abrogated sphingosine-1-phosphate-mediated sustained signaling, suggesting that sphingosine-1-phosphate lyase by facilitating S1P1 receptor recycling is essential for sphingosine-1-phosphate-mediated sustained signaling, and that synthetic agonists are functional antagonists because they are not sphingosine-1-phosphate lyase substrates
Manually annotated by BRENDA team
-
CRL 1392 (ATCC)
Manually annotated by BRENDA team
-
silencing of sphingosine 1-phosphate lyase enhances survival after irradiation or chemotherapy by decreasing expression of proteins involved in sensing and repairing DNA damage or apoptosis, respectively. Enforced expression of sphingosine 1-phosphate lyase sensitizes cancer cells to irradiation or docetaxel by tilting the ceramide/sphingosine 1-phosphate balance toward cell death
Manually annotated by BRENDA team
-
sphingosine-1-phosphate lyase expression is almost exclusively restricted to cells on the parenchymal side of marginal reticular cells, consistent with a role in maintaining the S1P gradient between the sinuses and the parenchyma
Manually annotated by BRENDA team
-
CCL 34 (ATCC)
Manually annotated by BRENDA team
sphingosine-1-phosphate lyase is induced during myoblast differentiation
Manually annotated by BRENDA team
-
of the olfactory bulb, cerebral cortex, midbrain, hindbrain, and cerebellum, high expression rate
Manually annotated by BRENDA team
the enzyme is highly enriched in olfactory mucosal epithelium
Manually annotated by BRENDA team
-
silencing of sphingosine 1-phosphate lyase enhances survival after irradiation or chemotherapy by decreasing expression of proteins involved in sensing and repairing DNA damage or apoptosis, respectively. Enforced expression of sphingosine 1-phosphate lyase sensitizes cancer cells to irradiation or docetaxel by tilting the ceramide/sphingosine 1-phosphate balance toward cell death
Manually annotated by BRENDA team
-
higher enzyme activity than in F9 EC cells
Manually annotated by BRENDA team
-
in fresh human prostatectomy specimens, a remarkable decrease in sphingosine 1-phosphate lyase enzymatic activity is found in tumor samples, as compared with normal adjacent tissues. A significant relationship between loss of sphingosine 1-phosphate lyase expression and higher Gleason score is confirmed. Sphingosine 1-phosphate lyase protein expression and activity are inversely correlated with those of sphingosine kinase-1, the enzyme producing sphingosine 1-phosphate. Sphingosine 1-phosphate lyase and sphingosine kinase expressions are independently predictive of aggressive cancer on tissue microarray
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
thymic and splenic stromal cell
Manually annotated by BRENDA team
-
circulating T lymphocyte
Manually annotated by BRENDA team
-
lowest expression detected
Manually annotated by BRENDA team
-
high expression rate
Manually annotated by BRENDA team
-
spingosine 1-phosphate lyase is modestly expressed at day 20 of pregnancy antd then decreases. In contrast, sphingosine 1-phosphate receptor mRNA increases in endometrium and caruncular stroma of the gravid uterine horn
Manually annotated by BRENDA team
additional information