4.1.2.27: sphinganine-1-phosphate aldolase
This is an abbreviated version!
For detailed information about sphinganine-1-phosphate aldolase, go to the full flat file.
Word Map on EC 4.1.2.27
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4.1.2.27
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sphingolipids
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ceramide
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sphingoid
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egress
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lymphopenia
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dihydrosphingosine-1-phosphate
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medicine
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fingolimod
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s1p-degrading
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sphks
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4-deoxypyridoxine
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steroid-resistant
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analysis
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lyase-deficient
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s1p-dependent
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spinster
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s1p-induced
- 4.1.2.27
- sphingolipids
- ceramide
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sphingoid
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egress
- lymphopenia
- dihydrosphingosine-1-phosphate
- medicine
- fingolimod
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s1p-degrading
-
sphks
- 4-deoxypyridoxine
-
steroid-resistant
- analysis
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lyase-deficient
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s1p-dependent
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spinster
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s1p-induced
Reaction
Synonyms
aldolase, dihydrosphingosine 1-phosphate, Dihydrosphingosine 1-phosphate aldolase, dihydrosphingosine phosphate lyase, Dpl1, Dpl1p, LegS2, S-1-P-lyase, S1P lyase, S1P-lyase, S1PL, S1PL2021, Sgpl1, sphinganine 1-phosphate lyase, sphinganine-1-phosphate aldolase, sphinganine-1-phosphate lyase, sphinganine-1-phosphate-alkanal-lyase, sphingosine 1-phosphate lyase, sphingosine phosphate lyase, sphingosine-1-phosphate lyase, sphingosine-phosphate lyase, SPL, SPL1
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 4.1.2.27 - sphinganine-1-phosphate aldolase
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REACTION DIAGRAM
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
pathway of sphingomyelin degradation, sphingosine 1-phosphate is an important element of signal transduction pathways that regulate cell proliferation and cell death
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ir
phosphoethanolamine + palmitaldehyde
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ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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?
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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ir
sphinganine 1-phosphate
phosphoethanolamine + palmitaldehyde
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ir
additional information
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critical role in maintenance of intestinal integrity and normal reproduction
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metabolic pathways of the enzyme substrates
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role in ceramide metabolism and cell fate
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role in ceramide metabolism and cell fate
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acts on 1-phosphorylated derivatives of sphingoid bases, products are an aliphatic fatty aldehyde and phosphoethanolamine
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additional information
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metabolic pathways of the enzyme substrates
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additional information
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enzyme is responsible for the ultimate step in sphingolipid breakdown, converting phosphorylated long chain bases into ethanolamine phosphate and fatty aldehyde
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metabolic relationship between substrates and products of biosynthesis and degradation of sphingosine bases
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additional information
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enzyme catalyzes a rate-limiting step in sphingolipid catabolism
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additional information
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metabolic pathways of the enzyme substrates
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