4.1.2.27: sphinganine-1-phosphate aldolase

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For detailed information about sphinganine-1-phosphate aldolase, go to the full flat file.

Reaction

Synonyms

aldolase, dihydrosphingosine 1-phosphate, Dihydrosphingosine 1-phosphate aldolase, dihydrosphingosine phosphate lyase, Dpl1, Dpl1p, LegS2, S-1-P-lyase, S1P lyase, S1P-lyase, S1PL, S1PL2021, Sgpl1, sphinganine 1-phosphate lyase, sphinganine-1-phosphate aldolase, sphinganine-1-phosphate lyase, sphinganine-1-phosphate-alkanal-lyase, sphingosine 1-phosphate lyase, sphingosine phosphate lyase, sphingosine-1-phosphate lyase, sphingosine-phosphate lyase, SPL, SPL1

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.27 sphinganine-1-phosphate aldolase

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Results	in table
114	AA Sequence
16	Application
1	CAS Registry Number
17	Cloned(Commentary)
49	Cofactor
4	Crystallization (Commentary)
466	Disease/ Diagnostics
7	Expression
42	General Information
2	General Stability
66	IC50 Value
224	Inhibitors
1	kcat/KM [mM/s]
14	Ki Value [mM]
13	KM Value [mM]
53	Localization
2	Metals/Ions
12	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
118	Organism
5	Pathway
16	PDB ID
2	pH Optimum
4	Posttranslational Modification
32	Protein Variants
6	Purification (Commentary)
18	Reaction
2	Reaction Type
115	Reference
192	Source Tissue
8	Specific Activity [micromol/min/mg]
4	Storage Stability
141	Substrates and Products (Substrate)
17	Subunits
152	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

KM Value

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KM Value on EC 4.1.2.27 - sphinganine-1-phosphate aldolase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0194

(2E)-hexadecenal

Burkholderia pseudomallei

Q63IP8

at pH 7.5 and 37°C

748365

0.035

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled sphinganine 1-phosphate

Homo sapiens

-

37°C

707358

0.006

C17-sphinganine-1-phosphate

Mus musculus

-

pH 7.4, 37°C

727299

0.009

D-(+)-erythro-dihydrosphingosine 1-phosphate

Rattus norvegicus

-

liver enzyme

5118

-

0.016

deoxysphinganine 1-phosphonate

Rattus norvegicus

-

-

5115

0.0201

Dihydrosphingosine 1-phosphonate

Homo sapiens

-

in 0.6 mM EDTA, 0.4 mM pyridoxal 5'-phosphate, 3 mM dithiothreitol mM sucrose, 36 mM potassium phosphate buffer, and 36 mM NaF containing 0.08% Triton X-100

681269

0.009 - 0.11

sphinganine 1-phosphate

4 entries

0.11

sphinganine-phosphate

Tetrahymena pyriformis

-

-

5119

0.0057 - 0.0146

sphingosine 1-phosphate

2 entries

0.009 - 0.016

sphinganine 1-phosphate

Rattus norvegicus

-

-

653122

0.016

sphinganine 1-phosphate

Rattus norvegicus

-

-

5115

0.0482

sphinganine 1-phosphate

Burkholderia pseudomallei

Q63IP8

at pH 7.5 and 37°C

748365

0.11

sphinganine 1-phosphate

Tetrahymena pyriformis

-

-

653122

0.0057

sphingosine 1-phosphate

Mus musculus

-

in 35 mM potassium phosphate buffer (pH 7.4), 0.6 mM EDTA, 70 mM sucrose, 36 mM sodium fluoride, 0.57 mM pyridoxal 5'-phosphate, at 37°C

713741

0.0146

sphingosine 1-phosphate

Homo sapiens

-

in 0.6 mM EDTA, 0.4 mM pyridoxal 5'-phosphate, 3 mM dithiothreitol mM sucrose, 36 mM potassium phosphate buffer, and 36 mM NaF containing 0.08% Triton X-100

681269