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4.1.2.27: sphinganine-1-phosphate aldolase

This is an abbreviated version!
For detailed information about sphinganine-1-phosphate aldolase, go to the full flat file.

Word Map on EC 4.1.2.27

Reaction

sphinganine 1-phosphate
=
Phosphoethanolamine
 +
palmitaldehyde

Synonyms

aldolase, dihydrosphingosine 1-phosphate, Dihydrosphingosine 1-phosphate aldolase, dihydrosphingosine phosphate lyase, Dpl1, Dpl1p, LegS2, S-1-P-lyase, S1P lyase, S1P-lyase, S1PL, S1PL2021, Sgpl1, sphinganine 1-phosphate lyase, sphinganine-1-phosphate aldolase, sphinganine-1-phosphate lyase, sphinganine-1-phosphate-alkanal-lyase, sphingosine 1-phosphate lyase, sphingosine phosphate lyase, sphingosine-1-phosphate lyase, sphingosine-phosphate lyase, SPL, SPL1

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.27 sphinganine-1-phosphate aldolase

Engineering

Engineering on EC 4.1.2.27 - sphinganine-1-phosphate aldolase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K271A
C218G
reduced enzyme activity
C317S
reduced enzyme activity
C344A
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
C65L
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
C65L/K67L
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
C65L/K67L/S70L/N71L
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
DELTA1-16
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
DELTA1-31
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
DELTA1-31/C65L/K67L/S70L/N71L
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
DELTA1-54
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
DELTA1-57
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
DELTA1-81
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
H129A
-
the mutation drastically impairs enzyme activity
H268A
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
H340A
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
K380A
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
K386A
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
K67L
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
K67L/S70L
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
N6A
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
N71L
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
S70L
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
S70L/N71L
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
Y105F
-
inactive
Y174F
-
the mutant is partially active
Y554A
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
Y554F
mutant constructed for structure-function analysis of Dpl1p to discover possible modes of regulation
H129A
-
the mutation drastically impairs enzyme activity
additional information
-
enzyme null mutant, exhibits dihydrosphingosine-1-phosphate lyase activity