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4.1.2.23: 3-deoxy-D-manno-octulosonate aldolase

This is an abbreviated version!
For detailed information about 3-deoxy-D-manno-octulosonate aldolase, go to the full flat file.

Word Map on EC 4.1.2.23

Reaction

3-deoxy-D-manno-octulosonate
=
pyruvate
 +
D-arabinose

Synonyms

2-dehydro-3-deoxyphosphooctonate aldolase, 2-keto-3-deoxyoctonic aldolase, 3-deoxy-D-manno-octulosonic aldolase, 3-deoxyoctulosonic aldolase, aldolase, 2-keto-3-deoxyoctonate, D-sialic acid aldolase mutant V251I, KDO aldolase, KdsA, L-3-deoxy-manno-2-octulosonic acid aldolase, L-KDO aldolase, RS-aldolase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.23 3-deoxy-D-manno-octulosonate aldolase

Substrates Products

Substrates Products on EC 4.1.2.23 - 3-deoxy-D-manno-octulosonate aldolase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-deoxy-D-manno-octulosonate
?
show the reaction diagram
3-deoxy-D-manno-octulosonate
pyruvate + D-arabinose
show the reaction diagram
3-deoxy-L-manno-octulosonate
pyruvate + L-arabinose
show the reaction diagram
-
-
-
-
r
D-sialic acid
N-acetyl-D-mannosamine + pyruvate
show the reaction diagram
-
the RS-aldolase has a 5.8fold higher cleavage rate toward 3-deoxy-L-manno-octulosonate than toward D-sialic acid
-
-
r
N-acetyl-D-mannosamine + pyruvate
D-sialic acid
show the reaction diagram
-
-
-
-
r
pyruvate + 2-deoxy-2-fluoro-D-arabinose
3,5-dideoxy-5-fluoro-alpha-D-manno-2-octulosonic acid
show the reaction diagram
pyruvate + 2-deoxy-D-ribose
3,5-dideoxy-alpha-D-manno-2-octulosonic acid
show the reaction diagram
pyruvate + 5-azido-2,5-dideoxy-D-ribose
?
show the reaction diagram
-
at 15% of the activity with D-arabinose
-
-
?
pyruvate + D-altrose
D-erythrose + D-glyceraldehyde
show the reaction diagram
pyruvate + D-arabinose
3-deoxy-D-manno-octulosonate
show the reaction diagram
pyruvate + D-erythrose
?
show the reaction diagram
pyruvate + D-glyceraldehyde
2-dehydro-3-deoxy-D-galactonate
show the reaction diagram
pyruvate + D-lyxose
?
show the reaction diagram
-
at 35% of the activity with D-arabinose
-
-
?
pyruvate + D-ribose
3-deoxy-L-glycero-L-galacto-2-nonulosonic acid
show the reaction diagram
-
at 72% of the activity with D-arabinose
-
?
pyruvate + D-ribose
?
show the reaction diagram
pyruvate + D-threose
?
show the reaction diagram
pyruvate + L-arabinose
3-deoxy-L-manno-octulosonate
show the reaction diagram
-
-
-
-
r
pyruvate + L-glyceraldehyde
2-keto-3-deoxy-L-gluconic acid
show the reaction diagram
pyruvate + L-mannose
3-deoxy-alpha-D-arabino-2-heptulosonic acid
show the reaction diagram
-
-
-
?