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4.1.2.21: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase

This is an abbreviated version!
For detailed information about 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, go to the full flat file.

Word Map on EC 4.1.2.21

Reaction

2-dehydro-3-deoxy-6-phospho-D-galactonate
=
pyruvate
+
D-glyceraldehyde 3-phosphate

Synonyms

2-dehydro-3-deoxy-6-phosphogalactonate aldolase, 2-dehydro-3-deoxyphosphogalactonate aldolase, 2-keto-3-deoxy-6-phosphogalactonate aldolase, 2-keto-3-deoxy-6-phosphogalactonic aldolase, 2-keto-3-deoxygalactonate-6-phosphate aldolase, 2-oxo-3-deoxy-6-phosphogalactonate aldolase, 2-oxo-3-deoxygalactonate 6-phosphate aldolase, 6-phospho-2-dehydro-3-deoxygalactonate aldolase, 6-Phospho-2-keto-3-deoxygalactonate aldolase, aldolase, phospho-2-keto-3-deoxygalactonate, DgoA, KDPGal, KDPGal aldolase, Phospho-2-keto-3-deoxygalactonic aldolase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.21 2-dehydro-3-deoxy-6-phosphogalactonate aldolase

Engineering

Engineering on EC 4.1.2.21 - 2-dehydro-3-deoxy-6-phosphogalactonate aldolase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F33I/D58N/Q72H/A75V/V85A/V154F
-
higher activity compared to the wild type enzyme
V154T
the mutant shows reduced activity compared to the wild type enzyme
additional information
-
mutant NR8.276-2 exhibits a 60fold improvement in the ratio kcat/KM relative to that of the wild type enzyme