4.1.1.77: 2-oxo-3-hexenedioate decarboxylase

This is an abbreviated version!
For detailed information about 2-oxo-3-hexenedioate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.77

4.1.1.77

hydratase

catechols

4-hydroxy-2-oxovalerate

2-hydroxymuconic

tautomerase

putida

meta-cleavage

aldolase

acetaldehyde

2-hydroxy-2,4-pentadienoate

stereochemical

2-aminophenols

dehydrogenative

meta-fission

xylf

d2o

2-aminomuconate

extradiol

6-semialdehyde

metal-dependent

fumarylacetoacetate

synthesis

Reaction

(3E)-2-oxohex-3-enedioate

=

2-oxopent-4-enoate

+

CO2

Synonyms

4-OD, 4-oxalocrotonate decarboxylase, 4OD, Decarboxylase, 4-oxalocrotonate, NahK, Oxalocrotonate decarboxylase

ECTree

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.77 2-oxo-3-hexenedioate decarboxylase

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Results	in table
654	AA Sequence
2	Application
1	CAS Registry Number
4	Cloned(Commentary)
1	Crystallization (Commentary)
17	Inhibitors
5	kcat/KM [mM/s]
9	Ki Value [mM]
9	KM Value [mM]
2	Metals/Ions
4	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
42	Organism
23	Pathway
9	PDB ID
2	Protein Variants
3	Purification (Commentary)
4	Reaction
1	Reaction Type
17	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
29	Substrates and Products (Substrate)
3	Subunits
13	Synonyms
1	Systematic Name
9	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.1.1.77 - 2-oxo-3-hexenedioate decarboxylase

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(2E)-2-fluorohex-2-en-4-ynoic acid

Pseudomonas putida

-

-

(2E)-2-fluoropent-2-en-4-ynoic acid

Pseudomonas putida

-

-

(2E)-2-fluoropenta-2,4-dienoic acid

Pseudomonas putida

-

-

(2E,4E)-2-fluorohexa-2,4-dienedioic acid

Pseudomonas putida

-

-

(2E,4E)-2-fluorohexa-2,4-dienoic acid

Pseudomonas putida

-

-

(2Z)-2-fluorohex-2-en-4-ynedioic acid

Pseudomonas putida

-

-

(2Z)-2-fluoropent-2-en-4-ynoic acid

Pseudomonas putida

-

-

(2Z)-2-fluoropenta-2,4-dienoic acid

Pseudomonas putida

-

-

(2Z,4E)-2-fluorohexa-2,4-dienoic acid

Pseudomonas putida

-

-

CoCl2

-

1 mM, 47% remaining activity

FeSO4

-

1 mM, 23% remaining activity

iodoacetic acid

-

1 mM, 64% remaining activity

K3Fe(CN)6

-

1 mM, 36% remaining activity

MnSO4

-

1 mM, 9% remaining activity

N-Methylmaleimide

-

1 mM, 58% remaining activity

p-chloromercuribenzoic acid

-

1 mM, 54% remaining activity

Tiron

-

1 mM, 59% remaining activity

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Release 2023.1 (January 2023)