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4.1.1.74: indolepyruvate decarboxylase

This is an abbreviated version!
For detailed information about indolepyruvate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.74

Reaction

3-(Indol-3-yl)pyruvate
=
2-(indol-3-yl)acetaldehyde
+
CO2

Synonyms

Decarboxylase, indolepyruvate, Decarboxylase, indolepyruvate (Enterobacter agglomerans clone pMB2 gene ipdC reduced), GenBank L80006-derived protein GI 1507711, Indole-3-pyruvate decarboxylase, indole-3-pyruvic acid decarboxylase, Indolepyruvate decarboxylase, Indolepyruvate decarboxylase (Enterobacter herbocola strain 299R clone pMB2 gene ipdC reduced), Indolepyruvic acid decarboxylase, IpdC, Ipyr, IPyr decarboxylase, KivD

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.74 indolepyruvate decarboxylase

Engineering

Engineering on EC 4.1.1.74 - indolepyruvate decarboxylase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D29E
-
significant decrease in Km-values
E468D
-
slight decrease in Km-values
E52D
-
decrease in Km-value for 3-(indol-3-yl)pyruvate and pyruvate, increase in Km-value for benzoylformic acid
H115K
-
slight increase in Km-value for 3-(indol-3-yl)pyruvate and pyruvate, decrease in Km-value for benzoylformic acid
Q383T
-
decrease in Km-value for pyruvate
tyrR insertional mutant
activity of tyrR in Enterobacter cloacae UW5 is abolished by insertion of a tetracycline resistance cassette into the coding sequence, creating Enterobacter cloacae J35
additional information