4.1.1.65: phosphatidylserine decarboxylase

This is an abbreviated version!
For detailed information about phosphatidylserine decarboxylase, go to the full flat file.

Reaction

Synonyms

CT699, Decarboxylase, phosphatidylserine, phosphatidyl serine decarboxylase, Phosphatidylserine decarboxylase, phosphatidylserine decarboxylase 1, phosphatidylserine decarboxylase 2, phosphatidylserine decarboxylase2, PISD, PKH_072580, PS decarboxylase, PSD, PSD1, Psd1 enzyme, Psd1p, PSD2, Psd2p, PSD3, PSDC, Tb927.9.10080, type I PtdSer decarboxylase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.65 phosphatidylserine decarboxylase

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Results	in table
13	Activating Compound
32015	AA Sequence
4	Application
1	CAS Registry Number
8	Cloned(Commentary)
25	Disease/ Diagnostics
2	Expression
30	General Information
2	General Stability
40	Inhibitors
9	KM Value [mM]
98	Localization
6	Metals/Ions
27	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
287	Organism
6	Pathway
48	PDB ID
5	pH Optimum
1	pH Range
1	pH Stability
11	Posttranslational Modification
53	Protein Variants
4	Purification (Commentary)
4	Reaction
2	Reaction Type
111	Reference
24	Source Tissue
5	Specific Activity [micromol/min/mg]
6	Storage Stability
109	Substrates and Products (Substrate)
17	Subunits
98	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 4.1.1.65 - phosphatidylserine decarboxylase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

phosphatidyl-L-serine

?

5 entries

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

13 entries

additional information

?

-

4 entries

phosphatidyl-L-serine

?

Escherichia coli

-

-

4783

-

-

?

phosphatidyl-L-serine

?

Escherichia coli

-

the enzyme catalyzes the final step in the biosynthesis of phosphatidylethanolamine

4764, 4769

-

-

?

phosphatidyl-L-serine

?

Homo sapiens

-

important enzyme in the synthesis of phosphatidylethanolamine

4783

-

-

?

phosphatidyl-L-serine

?

Mammalia

-

important enzyme in the synthesis of phosphatidylethanolamine

4783

-

-

?

phosphatidyl-L-serine

?

Saccharomyces cerevisiae

-

important enzyme in the synthesis of phosphatidylethanolamine

4783

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Mus musculus

-

-

693510

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Mus musculus

-

disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects

662430

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Plasmodium knowlesi

-

-

727905

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Saccharomyces cerevisiae

-

-

661239, 693510, 694089, 727269, 727929, 727932, 727991, 728629

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Saccharomyces cerevisiae

P39006

-

694160

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Saccharomyces cerevisiae

-

phosphatidylethanolamine formed by phosphatidylserine decarboxylase 2 is the preferred substrate for phosphatidylcholine synthesis, phosphatidylethanolamine formed by phosphatidylserine decarboxylase 2 can be imported into mitochondria, although with moderate efficiency

661240

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Saccharomyces cerevisiae

-

phosphatidylserine decarboxylase 1 is the major source of cellular and mitochondrial phosphatidylethanolamine

661240

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Saccharomyces cerevisiae BY4741

-

-

727269, 727929

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Saccharomyces cerevisiae BY4742

-

-

728629

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Sinorhizobium meliloti 1021

Q9FDI9

-

692879

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Toxoplasma gondii

-

-

727992

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Toxoplasma gondii

-

liposomal phosphatidyl-L-serine

727907

-

-

?

Phosphatidyl-L-serine

Phosphatidylethanolamine + CO2

Toxoplasma gondii TaTi

-

liposomal phosphatidyl-L-serine

727907

-

-

?

additional information

?

-

Escherichia coli

-

enzyme of the phospholipid metabolism

4762

-

-

?

additional information

?

-

Rattus norvegicus

-

effect of the enzyme in neural excitation. The carboxyl groups of phosphatidylserine function as ion exchange sites in the nerve membrane

4763

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

the level of enzyme activity is partially and reversibly suppressed by inositol and further diminished by the combination of inositol and choline

4784

-

-

?

additional information

?

-

Salmonella enterica subsp. enterica serovar Typhimurium

-

enzyme of the phospholipid metabolism

4762

-

-

?