4.1.1.5: acetolactate decarboxylase
This is an abbreviated version!
For detailed information about acetolactate decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.5
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4.1.1.5
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diacetyl
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2,3-butanediol
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lactis
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lactococcus
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brewer
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diacetylactis
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biovar
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aerogenes
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butanediol
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brewing
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wort
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synthesis
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nutrition
- 4.1.1.5
- diacetyl
- 2,3-butanediol
- lactis
- lactococcus
-
brewer
- diacetylactis
-
biovar
- aerogenes
-
butanediol
- brewing
-
wort
- synthesis
- nutrition
Reaction
Synonyms
ADC, ALD, aldB, ALDC, alpha-Acetolactate decarboxylase, AlsD, BudA1, Decarboxylase, acetolactate
ECTree
4.1.1.5 acetolactate decarboxylaseAdvanced search results
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results (Engineering
Engineering on EC 4.1.1.5 - acetolactate decarboxylase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
E251A
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site-directed mutagenesis, the mutant shows highly reduced activity
E251Q
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site-directed mutagenesis, the mutant shows highly reduced activity
R142A
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site-directed mutagenesis, the mutant shows highly reduced activity
R142K
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site-directed mutagenesis, the mutant shows 60% reduced activity compared to the wild-type enzyme
T55A
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site-directed mutagenesis, the mutant shows 2.5fold increased activity compared to the wild-type enzyme
T55S
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site-directed mutagenesis, the mutant shows 2fold increased activity compared to the wild-type enzyme
K52D
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the mutant has almost no variation on enzyme activity, but exhibits improved stability over pH 4.0-5.0 compared to the wild type enzyme
K52E
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the mutant has almost no variation on enzyme activity, but exhibits improved stability over pH 4.0-5.0 compared to the wild type enzyme
N43D
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the mutant has almost no variation on enzyme activity, but exhibits improved stability over pH 4.0-5.0 compared to the wild type enzyme
N43D/K52D
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the mutant shows dramatically improved acidic stability with prolonged half-life of 3.5 h (compared to the wild type of 1.5 h) at pH 4.0
additional information
additional information
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decrease in the activity of Ald is a consequence of diacetyl accumulation in mutant UV-3
additional information
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decrease in the activity of Ald is a consequence of diacetyl accumulation in mutant UV-3
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additional information
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alpha-acetolactate decarboxylase-negative mutant 483 MI with similar growth and acidification characteristics as the parental strain CNRZ 483, the mutant accumulates alpha-acetolactate, which spontaneously degrades to acetoin and diacetyl
additional information
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enzyme deficiency in a mutant strain has no effect on its specific growth rate, the mutant accumulates alpha-acetolactate, which results in an increased diacetyl formation compared to wild-type strain
additional information
alpha-acetolactate decarboxylase-deficient mutant TIL865
additional information
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alpha-acetolactate decarboxylase-deficient mutant TIL865
additional information
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alpha-acetolactate decarboxylase-deficient mutant TIL865
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