4.1.1.43: phenylpyruvate decarboxylase
This is an abbreviated version!
For detailed information about phenylpyruvate decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.43
-
4.1.1.43
-
2-phenylethanol
-
decarboxylases
-
pdc5
-
isobutanol
-
tyrosol
-
rose-like
-
4-hydroxyphenylacetic
-
2-keto
-
fusel
-
4-hydroxyphenylpyruvate
-
diphosphate-dependent
-
isoamyl
-
synthesis
- 4.1.1.43
- 2-phenylethanol
- decarboxylases
- pdc5
- isobutanol
- tyrosol
-
rose-like
-
4-hydroxyphenylacetic
-
2-keto
-
fusel
- 4-hydroxyphenylpyruvate
-
diphosphate-dependent
-
isoamyl
- synthesis
Reaction
Synonyms
ARO10, Decarboxylase, phenylpyruvate, KDC, phenyl/indolepyruvate decarboxylase, phenylpyruvate decarboxylase, PpdA, PPDC, YDR380W
ECTree
4.1.1.43 phenylpyruvate decarboxylaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.1.1.43 - phenylpyruvate decarboxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-ketohexanoic acid
pentanal + CO2
-
1% activity compared to phenylpyruvate
-
-
?
2-oxo-4-phenylbutanoic acid
?
9% activity compared to phenylpyruvate
-
-
?
2-Oxo-isohexanoate
?
-
at approximately 5% of the activity with phenylpyruvate
-
-
?
2-oxobutanoic acid
?
0.2% activity compared to phenylpyruvate
-
-
?
2-oxohexanoic acid
?
6% activity compared to phenylpyruvate
-
-
?
2-oxopentanoic acid
?
1% activity compared to phenylpyruvate
-
-
?
3-methyl-2-oxobutanoic acid
?
1% activity compared to phenylpyruvate
-
-
?
3-methyl-2-oxopentanoic acid
?
2% activity compared to phenylpyruvate
-
-
?
4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
63% activity compared to phenylpyruvate
-
-
?
4-methyl-2-oxopentanoic acid
?
6% activity compared to phenylpyruvate
-
-
?
4-methylthio-2-oxobutanoic acid
?
6% activity compared to phenylpyruvate
-
-
?
4-phenyl-2-oxobutanoic acid
3-phenylpropanal + CO2
-
2.3% activity compared to phenylpyruvate
-
-
?
5-phenyl-2-oxopentanoic acid
4-phenylbutanal + CO2
-
110% activity compared to phenylpyruvate
-
-
?
benzoylformic acid
?
0.2% activity compared to phenylpyruvate
-
-
?
indole-3-pyruvic acid + acetaldehyde
3-hydroxy-1-(3-indoyl)-2-butanone
Achromobacter eurydice
-
-
-
?
pyruvic acid
?
0.02% activity compared to phenylpyruvate
-
-
?
2-Oxo-gamma-ethylthiobutanoate
beta-Ethiopropanal + CO2
-
at approximately 30% of the activity with phenylpyruvate
-
-
?
2-Oxohexanoate
Pentanal + CO2
-
at approximately 31% of the activity with phenylpyruvate
-
-
?
4-methylthio-2-oxobutanoate
beta-methiopropanal + CO2
-
at approximately 23% of the activity with phenylpyruvate
-
-
?
indole-3-pyruvate
indoleacetaldehyde + CO2
-
10.4% activity compared to phenylpyruvate
-
-
?
indole-3-pyruvate
indoleacetaldehyde + CO2
preferred substrate, 100% activity
-
-
?
indolepyruvate
indoleacetaldehyde + CO2
-
higher affinity for indolepyruvate than for phenylpyruvate but a 10fold higher specificity for the latter
-
-
?
Indolepyruvate
Indoleethanal + CO2
-
at 48% of the activity with phenylpyruvate
-
-
?
Phenylpyruvate
Phenylacetaldehyde + CO2
-
converts phenylpyruvate with a 10fold higher specificity than indolepyruvate despite a slightly higher affinity for the latter
-
-
?
Phenylpyruvate
Phenylacetaldehyde + CO2
-
first step in the Ehrlich pathway
-
?
Phenylpyruvate
Phenylacetaldehyde + CO2
preferred substrate, 100% activity
-
-
?
phenylpyruvate + acetaldehyde
3-hydroxy-1-phenyl-2-butanone
Achromobacter eurydice
-
stereoselective
-
?
phenylpyruvate + acetaldehyde
3-hydroxy-1-phenyl-2-butanone
Achromobacter eurydice
-
stereoselective, best yields of 34-35% is obtained at acetaldehyde concentrations of 50-100 mM with 5 mM concentration of phenylpyruvate using the crude cell extract
-
?
phenylpyruvate + acetaldehyde
3-hydroxy-1-phenyl-2-butanone
Achromobacter eurydice SC 16386
-
stereoselective
-
?
phenylpyruvate + acetaldehyde
3-hydroxy-1-phenyl-2-butanone
Achromobacter eurydice SC 16386
-
stereoselective, best yields of 34-35% is obtained at acetaldehyde concentrations of 50-100 mM with 5 mM concentration of phenylpyruvate using the crude cell extract
-
?
phenylpyruvate + acetaldehyde
3-hydroxy-1-phenyl-2-butanone
-
stereoselective
-
?
phenylpyruvate + acetaldehyde
3-hydroxy-1-phenyl-2-butanone
-
stereoselective
-
?
phenylpyruvate + acetaldehyde
3-hydroxy-1-phenyl-2-butanone
-
-
-
?
phenylpyruvate + n-butyraldehyde
3-hydroxy-1-phenyl-2-hexanone
Achromobacter eurydice
-
-
-
?
phenylpyruvate + n-butyraldehyde
3-hydroxy-1-phenyl-2-hexanone
Achromobacter eurydice SC 16386
-
-
-
?
phenylpyruvate + pentanal
3-hydroxy-1-phenyl-2-heptanone
Achromobacter eurydice
-
-
-
?
phenylpyruvate + pentanal
3-hydroxy-1-phenyl-2-heptanone
Achromobacter eurydice SC 16386
-
-
-
?
phenylpyruvate + propionaldehyde
3-hydroxy-1-phenyl-2-pentanone
Achromobacter eurydice
-
-
-
?
phenylpyruvate + propionaldehyde
3-hydroxy-1-phenyl-2-pentanone
Achromobacter eurydice SC 16386
-
-
-
?
additional information
?
-
Achromobacter eurydice
-
the acyloic condensation yield decreases with increasing chain length for straigth chain aliphatic aldehydes from 76% for acetaldehyde to 42% for valeraldehyde, using longer chain aldehydes, aromatic aldehydes, bromoacetaldehyde, bromopropionaldehyde and acrolin, either none or negligible amounts of the acyloin products are obtained
-
?
additional information
?
-
Achromobacter eurydice SC 16386
-
the acyloic condensation yield decreases with increasing chain length for straigth chain aliphatic aldehydes from 76% for acetaldehyde to 42% for valeraldehyde, using longer chain aldehydes, aromatic aldehydes, bromoacetaldehyde, bromopropionaldehyde and acrolin, either none or negligible amounts of the acyloin products are obtained
-
?
additional information
?
-
-
completely inactive toward benzoylformate
-
-
?
additional information
?
-
-
no activity with benzoylformate and indole-glyoxylic acid
-
-
?
additional information
?
-
-
enzyme is involved in Phe catabolism
-
-
?
additional information
?
-
-
double mutants blocked in both phenylalanine dehydrogenase and phenylpyruvate decarboxylase completely fail to catabolize Phe
-
-
?
additional information
?
-
-
double mutants blocked in both phenylalanine dehydrogenase and phenylpyruvate decarboxylase completely fail to catabolize Phe
-
-
?
additional information
?
-
PPDC is essentially unable to utilize pyruvate and 3-indoleglyoxylic acid
-
-
?
additional information
?
-
-
PPDC is essentially unable to utilize pyruvate and 3-indoleglyoxylic acid
-
-
?
