4.1.1.43: phenylpyruvate decarboxylase

This is an abbreviated version!
For detailed information about phenylpyruvate decarboxylase, go to the full flat file.

Reaction

Synonyms

ARO10, Decarboxylase, phenylpyruvate, KDC, phenyl/indolepyruvate decarboxylase, phenylpyruvate decarboxylase, PpdA, PPDC, YDR380W

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.43 phenylpyruvate decarboxylase

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Results	in table
77	AA Sequence
2	Application
1	CAS Registry Number
9	Cloned(Commentary)
8	Cofactor
2	Crystallization (Commentary)
3	Expression
4	General Information
1	General Stability
10	Inhibitors
31	kcat/KM [mM/s]
40	KM Value [mM]
5	Metals/Ions
9	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
55	Organism
9	Pathway
10	PDB ID
4	pH Optimum
3	pH Stability
6	Protein Variants
9	Purification (Commentary)
1	Reaction
1	Reaction Type
37	Reference
12	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
81	Substrates and Products (Substrate)
8	Subunits
20	Synonyms
1	Systematic Name
38	Turnover Number [1/s]

Engineering

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Engineering on EC 4.1.1.43 - phenylpyruvate decarboxylase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

E545L

Saccharomyces cerevisiae

Q06408

the mutant shows 730fold decrease in kcat (phenylpyruvate) and 38fold decrease in kcat (indole-3-pyruvate) compared to the wild type enzyme

714975

I335Y

Saccharomyces cerevisiae

Q06408

compared to the wild type enzyme, the mutant exhibits 0.6% catalytic efficiency with phenylpyruvate, 33% catalytic efficiency with 2-oxohexanoic acid, 213% catalytic efficiency with 2-oxopentanoic acid, 1.7% catalytic efficiency with 2-oxobutanoic acid, and 7% catalytic efficiency with pyruvic acid

714975

I335Y/M624W

Saccharomyces cerevisiae

Q06408

compared to the wild type enzyme, the mutant exhibits 0.02% catalytic efficiency with phenylpyruvate, 2.3% catalytic efficiency with 2-oxohexanoic acid, 25% catalytic efficiency with 2-oxopentanoic acid, no activity with 2-oxobutanoic acid, and 59% catalytic efficiency with pyruvic acid

714975

M624W

Saccharomyces cerevisiae

Q06408

compared to the wild type enzyme, the mutant exhibits 3.4% catalytic efficiency with phenylpyruvate, 32% catalytic efficiency with 2-oxohexanoic acid, 131% catalytic efficiency with 2-oxopentanoic acid, 1.4% catalytic efficiency with 2-oxobutanoic acid, and 152% catalytic efficiency with pyruvic acid

714975

Q448W

Saccharomyces cerevisiae

Q06408

compared to the wild type enzyme, the mutant exhibits 45% catalytic efficiency with phenylpyruvate, 16% catalytic efficiency with 2-oxohexanoic acid, 231% catalytic efficiency with 2-oxopentanoic acid, 62% catalytic efficiency with 2-oxobutanoic acid, and 130% catalytic efficiency with pyruvic acid

714975

additional information

Azospirillum brasilense

-

an ipdC-knockout mutant produces only 10% (w/v) of the wild type indole-3-acetic acid production level

680508