4.1.1.4: acetoacetate decarboxylase
This is an abbreviated version!
For detailed information about acetoacetate decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.4
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4.1.1.4
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clostridium
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acetobutylicum
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beijerinckii
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solventogenesis
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solventogenic
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thiolase
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isopropanol
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acetoacetyl-coa
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acetone-butanol-ethanol
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primary-secondary
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phosphotransbutyrylase
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solvent-producing
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acidogenic
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synthesis
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analysis
- 4.1.1.4
- clostridium
- acetobutylicum
- beijerinckii
-
solventogenesis
-
solventogenic
-
thiolase
- isopropanol
- acetoacetyl-coa
-
acetone-butanol-ethanol
-
primary-secondary
- phosphotransbutyrylase
-
solvent-producing
-
acidogenic
- synthesis
- analysis
Reaction
Synonyms
AAD, AADase, AADC, acetoacetic acid decarboxylase, Acetoacetic decarboxylase, ADC, CP 28/CP 29, Decarboxylase, acetoacetate, Polymyxin MI
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4.1.1.4 acetoacetate decarboxylaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 4.1.1.4 - acetoacetate decarboxylase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2,4-Dinitrophenyl acetate
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acetylation and complete inactivation of the enzyme
Acetic anhydride
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acetylation and complete inactivation of the enzyme
levulinic acid
substrate inhibition is observed with levulinic acid concentration higher than 5 mM
Acetopyruvate
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the enzyme inhibitor compound is an enamine, obtained by the tautomerization of the Schiff base initially formed from inhibitor and enzyme
Borohydride
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borohydride plus acetoacetate or 2-oxopropane sulfonate irreversibly inhibits, without affecting the latent decarboxylase. Monovalent anions protect
HCN-
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inhibitory synergism between cyanide and carbonyl compounds. The effectiveness in descending order: acetaldehyde, acetone, cyclohexanone, methyl ethyl ketone, 3-hexanone, diethyl ketone
Monovalent anions
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at pH 7.0 and above, monovalent anions are entirely noncompetitive inhibitors, as the pH is lowered the inhibition becomes increasingly uncompetitive
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