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0.0017 - 0.16
2'-deoxyorotidine 5'-phosphate
9
4-Thioorotidine 5'-phosphate
-
-
5
5-Azaorotidine 5'-phosphate
-
-
4.7 - 570
5-Fluoroorotidine 5'-phosphate
22
Orotidine
-
pH 7.2, 23°C, mutant enzyme C155S
0.042 - 21
orotidine 5'-monophosphate
0.000007 - 985.8
orotidine 5'-phosphate
additional information
additional information
-
0.0017
2'-deoxyorotidine 5'-phosphate
pH 7.2, 25°C, D37A mutant
0.15
2'-deoxyorotidine 5'-phosphate
pH 7.2, 25°C, wild-type enzyme
0.16
2'-deoxyorotidine 5'-phosphate
pH 7.2, 25°C, T100A mutant
4.7
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/R235A
6.6
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant S154A/Q215A
8.2
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Y217A
16
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant S154A
29
5-Fluoroorotidine 5'-phosphate
-
K59A mutant
49
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/Y271F
92
5-Fluoroorotidine 5'-phosphate
-
mutant R235A, pH 7.1, 25°C, presence of 0.1 M NaCl
92
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant R235A
95
5-Fluoroorotidine 5'-phosphate
-
wild-type, pH 7.1, 25°C, presence of 0.1 M NaCl
95
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, wild-type enzyme
190
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A
242
5-Fluoroorotidine 5'-phosphate
-
wild type enzyme
430
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Y217F
570
5-Fluoroorotidine 5'-phosphate
-
-
0.042
orotidine 5'-monophosphate
S154/Q215A mutant
0.082
orotidine 5'-monophosphate
S154 mutant
15
orotidine 5'-monophosphate
wild type enzyme
21
orotidine 5'-monophosphate
Q215A mutant
0.000007
orotidine 5'-phosphate
-
pH 7.2, 23°C, mutant enzyme C155S
0.00023
orotidine 5'-phosphate
-
below, D96A mutant
0.00048
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/Y217F/R235A
0.0005
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant V155D, pH 7.1, 25°C
0.01 - 1
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant I96S, pH 7.1, 25°C
0.01 - 1
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant V155S, pH 7.1, 25°C
0.024
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant D70N, pH 7.1, 25°C
0.11
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Y217F/R235A
0.19 - 0.2
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/R235A
0.24
orotidine 5'-phosphate
mutant T159V/V182A/Y206F, pH 7.1, 25°C
0.34
orotidine 5'-phosphate
-
K59A mutant
0.36
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant L123S, pH 7.1, 25°C
0.5
orotidine 5'-phosphate
-
mutant D71C, pH 7.2, 25°C
0.52
orotidine 5'-phosphate
-
K59A mutant
0.56
orotidine 5'-phosphate
mutant T159V/V182A, pH 7.1, 25°C
0.64
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant L123N, pH 7.1, 25°C
0.69
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant I96T, pH 7.1, 25°C
0.7
orotidine 5'-phosphate
-
mutant D76C, pH 7.2, 25°C
0.75
orotidine 5'-phosphate
-
0.9
orotidine 5'-phosphate
pH 7.2, 25°C, D37A mutant
1
orotidine 5'-phosphate
mutant R160A/V182A, pH 7.1, 25°C
1
orotidine 5'-phosphate
-
mutant R235A, pH 7.1, 25°C, presence of 0.1 M NCl
1
orotidine 5'-phosphate
pH 7.1, 25°C, mutant R235A
1.1
orotidine 5'-phosphate
mutant R160A/Y206F, pH 7.1, 25°C
1.1
orotidine 5'-phosphate
mutant T159V/Y206F, pH 7.1, 25°C
1.4
orotidine 5'-phosphate
mutant Q185A, pH 7.1, 25°C
1.5
orotidine 5'-phosphate
mutant R203A, pH 7.1, 25°C
1.5
orotidine 5'-phosphate
mutant V182A/Y206F, pH 7.1, 25°C
2 - 8
orotidine 5'-phosphate
-
pH 7, constant above pH 7, declines below pH 7
2
orotidine 5'-phosphate
mutant R160A, pH 7.1, 25°C
2.3
orotidine 5'-phosphate
mutant T159V, pH 7.1, 25°C
3
orotidine 5'-phosphate
mutant V182A, pH 7.1, 25°C
3.2
orotidine 5'-phosphate
-
mutant T80S, pH 7.2, 25°C
4
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
wild-type, pH 7.1, 25°C
4.1
orotidine 5'-phosphate
mutant Y206F, pH 7.1, 25°C
4.85
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/Y271F
5.3
orotidine 5'-phosphate
wild-type, pH 7.1, 25°C
6.7
orotidine 5'-phosphate
-
7.2
orotidine 5'-phosphate
pH 7.2, 25°C, T100A mutant
7.5
orotidine 5'-phosphate
monofunctional enzyme expressed in Escherichia coli
7.5
orotidine 5'-phosphate
pH and temperature not specified in the publication, recombinant monofunctional enzyme, OMPDC activity
8.1
orotidine 5'-phosphate
-
-
13
orotidine 5'-phosphate
-
22°C, native ODCase expressed in yeast
13.7
orotidine 5'-phosphate
-
mutant Q201H, pH 7.2, 25°C
14 - 20
orotidine 5'-phosphate
-
pH 7.2, 25°C, not affected by NaCl concentration
14.4
orotidine 5'-phosphate
-
mutant D22G, pH 7.2, 25°C
15
orotidine 5'-phosphate
-
wild-type, pH 7.1, 25°C, presence of 0.1 M NaCl
15
orotidine 5'-phosphate
pH 7.1, 25°C, wild-type enzyme
15.6
orotidine 5'-phosphate
-
pH 8.0, 37°C
19
orotidine 5'-phosphate
-
-
19
orotidine 5'-phosphate
-
22-25°C, pH 7.2, recombinant ODCase expressed in Escherichia coli
20
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Y217F
20.7
orotidine 5'-phosphate
-
21
orotidine 5'-phosphate
-
pH 7.5, 55°C
22
orotidine 5'-phosphate
-
wild type enzyme
24
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A
24.6
orotidine 5'-phosphate
multienzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase
27
orotidine 5'-phosphate
-
mutant L130M, pH 7.2, 25°C
29.7
orotidine 5'-phosphate
-
mutant V167N, pH 7.2, 25°C
30.7
orotidine 5'-phosphate
pH and temperature not specified in the publication, recombinant multienzyme complex, OMPDC activity
41
orotidine 5'-phosphate
-
Q215A mutant
42
orotidine 5'-phosphate
-
wild-type, pH 7.2, 25°C
44
orotidine 5'-phosphate
-
wild-type enzyme
44
orotidine 5'-phosphate
pH 7.2, 25°C, wild-type enzyme
985.8
orotidine 5'-phosphate
pH and temperature not specified in the publication, recombinant bifunctional enzyme, OMPDC activity
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
50% reduced kcat-value for 4-thioorotidine 5'-phosphate compared with orotidine 5'-phosphate as substrate
-
additional information
additional information
-
high catalytic proficiency
-
additional information
additional information
-
highly proficient enzyme
-
additional information
additional information
-
remarkable catalytic power
-
additional information
additional information
-
very high catalytic proficiency
-
additional information
additional information
-
very proficient enzyme
-