4.1.1.23: orotidine-5'-phosphate decarboxylase

This is an abbreviated version!
For detailed information about orotidine-5'-phosphate decarboxylase, go to the full flat file.

Reaction

Synonyms

Decarboxylase, orotidine 5'-phosphate, More, ODCase, OMP decarboxylase, OMP-DC, OMPD, OMPDC, OMPDCase, OMPdecase, Orotate decarboxylase, Orotate monophosphate decarboxylase, Orotic decarboxylase, Orotidine 5'-monophosphate decarboxylase, Orotidine 5'-phosphate decarboxylase, orotidine 5-monophosphate decarboxylase, orotidine 5-phosphate decarboxylase, Orotidine monophosphate decarboxylase, Orotidine phosphate decarboxylase, Orotidine-5'-monophosphate decarboxylase, orotidine-5'-phosphate decarboxylase, orotidine-5-monophosphate decarboxylase, Orotidylate decarboxylase, Orotidylic acid decarboxylase, Orotidylic decarboxylase, Orotodylate decarboxylase, PbrURA3, PfODCase, PfOMPDC, pm-ura3, PyrF, ScOMPDC, UMP synthase, URA3, Uridine 5'-monophosphate synthase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.23 orotidine-5'-phosphate decarboxylase

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Results	in table
14	Activating Compound
45149	AA Sequence
6	Application
1	CAS Registry Number
46	Cloned(Commentary)
12	Cofactor
37	Crystallization (Commentary)
129	Disease/ Diagnostics
10	General Information
8	General Stability
10	IC50 Value
314	Inhibitors
75	kcat/KM [mM/s]
121	Ki Value [mM]
120	KM Value [mM]
5	Localization
19	Metals/Ions
32	Molecular Weight [Da]
81	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
163	Organism
7	Pathway
501	PDB ID
30	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
2	Posttranslational Modification
130	Protein Variants
43	Purification (Commentary)
29	Reaction
28	Reaction Type
141	Reference
4	Source Tissue
24	Specific Activity [micromol/min/mg]
9	Storage Stability
233	Substrates and Products (Substrate)
43	Subunits
173	Synonyms
1	Systematic Name
27	Temperature Optimum [°C]
12	Temperature Stability [°C]
97	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 4.1.1.23 - orotidine-5'-phosphate decarboxylase

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-15°C, storage of the high molecular weight forms in presence of 0.15 mM oxipurinol prevents the spontaneous dissociation which occures when these forms are stored in 50 mM potassium phosphate, pH 7.4

Homo sapiens

-

4171

-20°C, 20% glycerol, retention of full activity for more than 2 years

Saccharomyces cerevisiae

-

4188

-25°C, stable

Pisum sativum

-

4168

-70°C, dilute buffer plus 2 mM dithiothreitol, purified UMP synthase activity retains orotidine-5'-phosphate decarboxylase activity for several months

Mus musculus

-

4180

0-4°C, stable in 10 mM potassium phosphate buffer, pH 5.8-7.5, containing 5 mM 2-mercaptoethanol for several weeks

Saccharomyces cerevisiae

-

4172

0°C or -70°C, 5 mM potassium phosphate, pH 7.0, 2 mM dithiothreitol, rapid loss of orotidine-5'-phosphate decarboxylase activity of the orotidine-5'-phosphate decarboxylase domain of UMP synthase

Mus musculus

-

4180

4°C, purified recombinant bifunctional enzyme, stability property of both domains in the bifunctional enzyme in the absence or presence of 0.5 mM PRPP and 0.5 mM UMP: half-life of the OPRT activity is about 3-4 days and 3 weeks, respectively. The OMPDC activity is much more stable with half-life of about 3-4 weeks. 90% of the bifunctional protein, stored for 4 weeks, remains as a bifunctional protein band in SDS-PAGE and image analyses

Plasmodium falciparum

Q8T6J6

748831

4°C, stable for 1 week

Pseudomonas aeruginosa

-

4189

4°C, stable for 16 months

Saccharomyces cerevisiae

-

4188