4.1.1.23: orotidine-5'-phosphate decarboxylase

This is an abbreviated version!
For detailed information about orotidine-5'-phosphate decarboxylase, go to the full flat file.

Reaction

Synonyms

Decarboxylase, orotidine 5'-phosphate, More, ODCase, OMP decarboxylase, OMP-DC, OMPD, OMPDC, OMPDCase, OMPdecase, Orotate decarboxylase, Orotate monophosphate decarboxylase, Orotic decarboxylase, Orotidine 5'-monophosphate decarboxylase, Orotidine 5'-phosphate decarboxylase, orotidine 5-monophosphate decarboxylase, orotidine 5-phosphate decarboxylase, Orotidine monophosphate decarboxylase, Orotidine phosphate decarboxylase, Orotidine-5'-monophosphate decarboxylase, orotidine-5'-phosphate decarboxylase, orotidine-5-monophosphate decarboxylase, Orotidylate decarboxylase, Orotidylic acid decarboxylase, Orotidylic decarboxylase, Orotodylate decarboxylase, PbrURA3, PfODCase, PfOMPDC, pm-ura3, PyrF, ScOMPDC, UMP synthase, URA3, Uridine 5'-monophosphate synthase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.23 orotidine-5'-phosphate decarboxylase

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Results	in table
14	Activating Compound
45149	AA Sequence
6	Application
1	CAS Registry Number
46	Cloned(Commentary)
12	Cofactor
37	Crystallization (Commentary)
129	Disease/ Diagnostics
10	General Information
8	General Stability
10	IC50 Value
314	Inhibitors
75	kcat/KM [mM/s]
121	Ki Value [mM]
120	KM Value [mM]
5	Localization
19	Metals/Ions
32	Molecular Weight [Da]
81	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
163	Organism
7	Pathway
501	PDB ID
30	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
2	Posttranslational Modification
130	Protein Variants
43	Purification (Commentary)
29	Reaction
28	Reaction Type
141	Reference
4	Source Tissue
24	Specific Activity [micromol/min/mg]
9	Storage Stability
233	Substrates and Products (Substrate)
43	Subunits
173	Synonyms
1	Systematic Name
27	Temperature Optimum [°C]
12	Temperature Stability [°C]
97	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 4.1.1.23 - orotidine-5'-phosphate decarboxylase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Orotidine 5'-phosphate

?

3 entries

Orotidine 5'-phosphate

UMP + CO2

55 entries

additional information

?

-

Treponema denticola

-

the enzyme is required for 5-fluoroorotic acid toxicity

679903

-

-

?

Orotidine 5'-phosphate

?

Mus musculus

-

required for the biosynthesis of uridylic acid

4170

-

-

?

Orotidine 5'-phosphate

?

Pseudomonas aeruginosa

-

final step in pyrimidine biosynthesis

4189

-

-

?

Orotidine 5'-phosphate

?

Saccharomyces cerevisiae

-

final step in pyrimidine biosynthesis

4184

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Bacillus subtilis

-

-

649331

-

649331

?

Orotidine 5'-phosphate

UMP + CO2

Bacillus subtilis

-

-

650143

-

650143

?

Orotidine 5'-phosphate

UMP + CO2

Bacillus subtilis

-

-

694055

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Bacillus subtilis

P25971

catalyzes the final step in the de novo biosynthesis of uridine monophosphate

653646

-

653646

?

Orotidine 5'-phosphate

UMP + CO2

Blakeslea trispora

Q870M2

last common step in pyrimidine biosynthesis, constitutive expression

651380

-

651380

?

Orotidine 5'-phosphate

UMP + CO2

Blakeslea trispora NRRL2895(+)

Q870M2

last common step in pyrimidine biosynthesis, constitutive expression

651380

-

651380

?

Orotidine 5'-phosphate

UMP + CO2

Escherichia coli

-

-

649331

-

649331

?

Orotidine 5'-phosphate

UMP + CO2

Escherichia coli

-

-

694055, 694518

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Escherichia coli

-

catalyzes the last step in the de novo synthesis of UMP

649973

-

649973

?

Orotidine 5'-phosphate

UMP + CO2

Escherichia coli

-

last step in the de novo synthesis of pyrimidine nucleotides

652881

-

652881

?

Orotidine 5'-phosphate

UMP + CO2

Helicobacter pylori

-

-

694477

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Homo sapiens

-

-

693556, 694055, 694477, 716948

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Homo sapiens

P11172

-

695160

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Homo sapiens

P11172

UMP synthase is a bifunctional enzyme that catalyzes the penultimate and last steps in the de novo biosynthesis of UMP, the bifunctional enzyme combines the orotate phosphoribosyltransferase and the orotidine-5'-monophosphate decarboxylase activities on a single polypeptide chain

677324

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Methanococcus thermoautotrophicum

-

-

694055

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Methanothermobacter thermautotrophicus

-

-

650934

-

650934

?

Orotidine 5'-phosphate

UMP + CO2

Methanothermobacter thermautotrophicus

-

-

681286, 681320, 692755, 693558

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Methanothermobacter thermautotrophicus

O26232

-

693556, 694475, 694477

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Methanothermobacter thermautotrophicus

-

catalyzes the final step in the de novo biosynthesis of UMP

651572

-

651572

?

Orotidine 5'-phosphate

UMP + CO2

Methanothermobacter thermautotrophicus

-

catalyzes the last step of de novo pyrimidine synthesis

650145

-

650145

?

Orotidine 5'-phosphate

UMP + CO2

Methanothermobacter thermautotrophicus

-

last step in the biosynthesis of pyrimidine nucleotides

653647

-

653647

?

Orotidine 5'-phosphate

UMP + CO2

Myrothecium gramineum

Q2HZ31

-

679898

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Pestalotiopsis microspora

A0A0A0WDU2

-

747654

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Pestalotiopsis microspora NK17

A0A0A0WDU2

-

747654

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium falciparum

-

-

680570, 694055, 694477

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium falciparum

Q8T6J6

-

690945, 748831

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium falciparum

-

-

748831

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium falciparum

Q8IJH3

-

681320, 693556

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium falciparum

-

-

693556

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium falciparum

Q8IJH3

-

693558

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium falciparum

A0A1D3TG46

-

746944

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium falciparum

-

the sixth enzyme in the pathway catalyzing formation of uridine 5'-monophosphate

657769

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium falciparum

-

final step in the de novo synthesis of uridine 5'-monophosphate, UMP, defects in the enzyme are lethal in the malaria parasite

677396

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Plasmodium vivax

-

-

694055

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Rhodotorula toruloides

B3GF12

-

695277

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

-

649331

-

649331

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

-

649479

-

649479

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

-

649921

-

649921

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

-

650513

-

650513

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

-

652109

-

652109

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

-

678241, 682233, 690986, 692757, 694055

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

P03962

-

690984, 746572, 747089, 748024, 748039

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

catalyzes the critical final step in the pyrimidine biosynthetic pathway

649975

-

649975

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

catalyzes the final step of de novo pyrimidine nucleotide biosynthesis

649542

-

649542

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

P03962

catalyzes the final step of pyrimidine biosynthesis

650068

-

650068

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

production of UMP, the biosynthetic precursor of pyrimidine nucleotides

651942

-

651942

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae

-

the enzyme is the most effective pure protein catalyst known in nature

678582

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae ATCC 204508 / S288c

P03962

-

746572, 747089, 748024, 748039

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae BJ5424

-

-

650513

-

650513

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae BJ5424

-

production of UMP, the biosynthetic precursor of pyrimidine nucleotides

651942

-

651942

?

Orotidine 5'-phosphate

UMP + CO2

Saccharomyces cerevisiae BJ5464

-

catalyzes the final step of de novo pyrimidine nucleotide biosynthesis

649542

-

649542

?

Orotidine 5'-phosphate

UMP + CO2

Staphylococcus aureus

-

-

694477

-

-

?

Orotidine 5'-phosphate

UMP + CO2

Sulfolobus acidocaldarius

-

-

651345

-

651345

?

Orotidine 5'-phosphate

UMP + CO2

Sulfolobus acidocaldarius DG6 / ATCC 49426

-

-

651345

-

651345

?

Orotidine 5'-phosphate

UMP + CO2

Treponema denticola

-

the enzyme is required for de novo pyrimidine synthesis catalyzing the key final step in de novo synthesis of UMP

679903

-

-

?