4.1.1.23: orotidine-5'-phosphate decarboxylase

This is an abbreviated version!
For detailed information about orotidine-5'-phosphate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.23

Reaction

orotidine 5'-phosphate
=
UMP
+
CO2

Synonyms

More, Decarboxylase, orotidine 5'-phosphate, OMP decarboxylase, OMP-DC, Orotate monophosphate decarboxylase, Orotate decarboxylase, Orotic decarboxylase, Orotidine-5'-monophosphate decarboxylase, Orotidine phosphate decarboxylase, Orotidine 5'-monophosphate decarboxylase, Orotidine monophosphate decarboxylase, Orotidine 5'-phosphate decarboxylase, Orotidylate decarboxylase, Orotidylic decarboxylase, Orotidylic acid decarboxylase, Orotodylate decarboxylase, ODCase, OMPDCase, OMPdecase, UMP synthase, Uridine 5'-monophosphate synthase, OMPDC, OMPD, PfOMPDC, orotidine-5'-phosphate decarboxylase, PbrURA3, orotidine-5-monophosphate decarboxylase, orotidine 5-monophosphate decarboxylase, orotidine 5-phosphate decarboxylase, PfODCase, PyrF, URA3, ScOMPDC, pm-ura3

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.23 orotidine-5'-phosphate decarboxylase

General Stability

General Stability on EC 4.1.1.23 - orotidine-5'-phosphate decarboxylase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
1-ribosyloxipurinol 5'-phosphate prevents loss of activity during preincubation in absence of substrate, when the inhibitor concentration is high enough to inhibit the enzyme substantially
-
Asp-70 makes a crucial contribution to enzyme stability
-
conversion of the monomer to higher molecular weight forms is associated with increased stability
-
glycerol, 50% v/v is an effective stabilizer of the orotidine-5'-phosphate decarboxylase domain at 4°C, -20°C or -70°C
-
NaCl stabilizes the dimeric active enzyme form
-
orotidine 5'-phosphate and UMP stabilize
-
unliganded enzyme without bound UMP or OMP forms heavy precipitates during purification
unstable to repeated freezing and thawing
-