3.7.1.9: 2-hydroxymuconate-6-semialdehyde hydrolase
This is an abbreviated version!
For detailed information about 2-hydroxymuconate-6-semialdehyde hydrolase, go to the full flat file.
Word Map on EC 3.7.1.9
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3.7.1.9
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catechols
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extradiol
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sphingomonas
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2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
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2-hydroxy-6-oxohepta-2,4-dienoate
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lignin-related
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4-hydroxy-2-oxovalerate
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xylf
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paucimobilis
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5-carboxyvanillate
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4-oxalocrotonate
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m-cresol
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isopropylbenzene
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toluate
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3-methylcatechol
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molecular biology
- 3.7.1.9
- catechols
-
extradiol
- sphingomonas
- 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
- 2-hydroxy-6-oxohepta-2,4-dienoate
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lignin-related
- 4-hydroxy-2-oxovalerate
-
xylf
- paucimobilis
- 5-carboxyvanillate
- 4-oxalocrotonate
- m-cresol
-
isopropylbenzene
- toluate
- 3-methylcatechol
- molecular biology
Reaction
Synonyms
1H-3-Hydroxy-4-oxoquinaldine 2,4-dioxygenase, 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate, 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase, 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase, 2-hydroxymuconate semialdehyde hydrolase, 2-hydroxymuconate-semialdehyde hydrolase, 2-hydroxymuconic semialdehyde hydrolase, 6-isopropyl-HODA hydrolase, CumD, HcdC, HMSH, HOD, HOD hydrolase, hydrolase, 2-hydroxymuconate semialdehyde, hydroxymuconic semialdehyde hydrolase, meta-cleavage compound hydrolase, meta-cleavage product hydrolase, MfhA, TodF, XylF
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Substrates Products
Substrates Products on EC 3.7.1.9 - 2-hydroxymuconate-6-semialdehyde hydrolase
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REACTION DIAGRAM
2-hydroxy-5-methyl-6-oxohepta-2,4-dienoate + H2O
?
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no activity with isoenzyme HODHI, 41% of the activity with 2-hydroxy-6-oxohepta-2,4-dienoate, isoenzyme HODHII
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-
?
2-hydroxy-5-methyl-muconic semialdehyde + H2O
?
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3% of the activity with 2-hydroxy-6-oxohepta-2,4-dienoate, isoenzyme HODHI. 5% of the activity with 2-hydroxy-6-oxohepta-2,4-dienoate, isoenzyme HODHI
-
-
?
2-hydroxy-7-methyl-6-oxoocta-2,4-dienoate + H2O
?
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149% of the activity with 2-hydroxy-6-oxohepta-2,4-dienoate, isoenzyme HODHI, no activity with isoenzyme HODHII
-
-
?
3-allylcatechol ring-fission product + H2O
?
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 3-allylcatechol
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-
?
3-ethylcatechol ring-fission product + H2O
?
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 3-ethylcatechol
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-
?
3-propylcatechol ring-fission product + H2O
?
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 3-propylcatechol
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-
?
4-chlorocatechol ring-fission product + H2O
?
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 4-chlorocatechol
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-
?
4-ethylcatechol ring-fission product + H2O
?
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 4-ethylcatechol
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-
?
4-methylcatechol ring-fission product + H2O
?
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 4-methylcatechol
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-
?
4-propylcatechol ring-fission product + H2O
?
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 4-propylcatechol
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-
?
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 3-allylcatechol + H2O
?
-
-
-
-
?
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 3-ethylcatechol + H2O
?
-
-
-
-
?
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 3-methylcatechol + H2O
?
-
-
-
-
?
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 3-propylcatechol + H2O
?
-
-
-
-
?
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 4-chlorocatechol + H2O
?
-
-
-
-
?
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 4-ethylcatechol + H2O
?
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-
-
-
?
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 4-methylcatechol + H2O
?
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-
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-
?
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 4-propylcatechol + H2O
?
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-
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-
?
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon catechol + H2O
?
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-
-
-
?
2-hydroxy-5-methylmuconate-6-semialdehyde + H2O
?
prepared from 4-methylcatechol
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-
?
2-hydroxy-5-methylmuconate-6-semialdehyde + H2O
?
prepared from 4-methylcatechol
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-
?
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O
?
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slight hydrolysis
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-
?
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O
?
slight hydrolytic activity
-
-
?
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O
?
slight hydrolytic activity
-
-
?
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O
?
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slight hydrolysis
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-
?
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O
?
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-
-
?
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O
?
-
-
-
?
2-hydroxy-6-oxohepta-2,4-dienoate + H2O
?
Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
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-
-
-
?
formate + 2-oxopent-4-enoate
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-
-
?
2-hydroxy-6-oxohepta-2,4-dienoate + H2O
formate + 2-oxopent-4-enoate
prepared from 3-methylcatechol, best substrate
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-
?
2-hydroxy-6-oxohepta-2,4-dienoate + H2O
formate + 2-oxopent-4-enoate
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-
-
?
2-hydroxy-6-oxohepta-2,4-dienoate + H2O
formate + 2-oxopent-4-enoate
prepared from 3-methylcatechol, best substrate
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-
?
formate + 2-oxopent-4-enoate
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metabolism of 2-hydroxymuconate 6-semialdehyde through HMS hydrolase is predominant compared to metabolism by HMS dehydrogenase
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?
2-hydroxymuconate 6-semialdehyde + H2O
formate + 2-oxopent-4-enoate
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metabolism of 2-hydroxymuconate 6-semialdehyde through HMS hydrolase is predominant compared to metabolism by HMS dehydrogenase
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?
formate + 2-oxopent-4-enoate
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-
-
?
2-hydroxymuconate semialdehyde + H2O
formate + 2-oxopent-4-enoate
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-
-
?
2-hydroxymuconate semialdehyde + H2O
formate + 2-oxopent-4-enoate
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31% of the activity with 2-hydroxy-6-oxohepta-2,4-dienoate, isoenzyme HODHI. 12% of the activity with 2-hydroxy-6-oxohepta-2,4-dienoate, isoenzyme HODHII
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-
?
2-hydroxymuconate semialdehyde + H2O
formate + 2-oxopent-4-enoate
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-
-
-
?
2-hydroxymuconate semialdehyde + H2O
formate + 2-oxopent-4-enoate
Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
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-
-
-
?
2-hydroxymuconate semialdehyde + H2O
formate + 2-oxopent-4-enoate
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2-hydroxymuconate semialdehyde
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-
?
2-hydroxymuconate semialdehyde + H2O
formate + 2-oxopent-4-enoate
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2-hydroxymuconate semialdehyde
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-
?
formate + 2-oxopent-4-enoate
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-
-
?
2-hydroxymuconate-6-semialdehyde + H2O
formate + 2-oxopent-4-enoate
prepared from catechol
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-
?
3-methylcatechol ring-fission product + H2O
?
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 3-methylcatechol
-
-
?
3-methylcatechol ring-fission product + H2O
?
Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
-
meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon 3-methylcatechol
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-
?
catechol ring-fission product + H2O
?
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon catechol
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-
?
catechol ring-fission product + H2O
?
Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
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meta-cleavage product resulting from the action of catechol 2,3-oxygenase upon catechol
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-
?
?
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the non-inducible levels of the enzyme activity appears negligible for metabolic purposes
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-
?
additional information
?
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the non-inducible levels of the enzyme activity appears negligible for metabolic purposes
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-
?
additional information
?
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enzyme of salicylate oxidation pathway
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-
?
additional information
?
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can not hydrolyze 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
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-
?
additional information
?
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can not hydrolyze 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
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-
?
additional information
?
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no activity with (2E,4E)-2,4-dihydroxy-6-oxonona-2,4-dienedioic acid
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-
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additional information
?
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Pseudomonas mandelii 7HK4
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no activity with (2E,4E)-2,4-dihydroxy-6-oxonona-2,4-dienedioic acid
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-
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additional information
?
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Pseudomonas mandelii DSM 107615
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no activity with (2E,4E)-2,4-dihydroxy-6-oxonona-2,4-dienedioic acid
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-
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additional information
?
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enzyme is part of the pathway for the catabolism of toluene and m-xylene and p-xylene
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-
?
additional information
?
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enzyme of meta-cleavage pathway for the metabolism of benzoic acids to Krebs-cycle intermediates
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-
?
additional information
?
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enzyme of the hydrolytic branch of the meta-cleavage pathway for the catabolism of catechol and alkyl-substituted catechols
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-
?
additional information
?
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can not hydrolyze 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
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-
?
additional information
?
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Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
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enzyme is part of the pathway for the catabolism of toluene and m-xylene and p-xylene
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-
?
additional information
?
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the enzyme shows the ability to hydrolyze all the three ring cleavage products from catechols although with different efficiency
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-
?
additional information
?
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the enzyme shows the ability to hydrolyze all the three ring cleavage products from catechols although with different efficiency
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-
?
additional information
?
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the enzyme shows the ability to hydrolyze all the three ring cleavage products from catechols although with different efficiency
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-
?