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3.6.4.6: vesicle-fusing ATPase

This is an abbreviated version!
For detailed information about vesicle-fusing ATPase, go to the full flat file.

Word Map on EC 3.6.4.6

Reaction

ATP
+
H2O
=
ADP
 +
phosphate

Synonyms

AAA ATPase Vps4, AAA-ATPase, ATP phosphohydrolase, ATP6V0D1, ATP6V0D2, ATPase, ATPase N-ethylmaleimide sensitive factor, C06A1.1, C41C4.8, CDC-48.1, CDC-48.2, Cdc48, Cdc48p, Csc1p, Did6p, dNSF, dNSF-1, dNSF1, End13p, Grd13p, Helar-NSF, Hez-NSF, HsPEX1, HsPex1p, HsPex6p, membrane deformation AAA ATPase, N-ethyl maleimide sensitive factor, N-ethylmaleimide sensitive factor, N-ethylmaleimide sensitive fusion protein, N-ethylmaleimide sensitive-factor, N-ethylmaleimide-sensitive factor, N-ethylmaleimide-sensitive fusion protein, N-ethylmeleimide-sensitive factor, NEM-sensitive fusion protein, NSF, NSF ATPase, NSF protein, NSF-1, NSF2, nsfA, NSFII, p97, p97/VCP/Cdc48p, p97/VCP/Cdc48p homologue, p97ATPase, peptide p97, Pex1, Pex1p, pex22, Pex6p, PpPex1p, PpPex6p, rat Pex6p, Sec18, SEC18 gene product, SEC18p, SKD1, SKD1/VPS4B, SKD2, SKD2 protein, Sso0909, SsoVps4, suppresor of potassium transport growth defect, Suppressor of K+ Transport Growth Defect1, triple-A ATPase, V-ATPase, vacular protein sorting 4 B, vacuolar protein sorting 4, vacuolar protein sorting 4 protein, vasolin-containing protein, VCP, vesicle-fusing ATPase, Vesicular-fusion protein NSF, Vpl4p, Vps 4B, Vps4, Vps4 ATPase, VPS4 gene product, Vps4p, Vps4p AAA ATPase, Vpt10p

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
                3.6.4.6 vesicle-fusing ATPase

Activating Compound

Activating Compound on EC 3.6.4.6 - vesicle-fusing ATPase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ist1
-
addition of the endosomal sorting complex required for the transport III (ESCRT-III) subunit binding partner of Ist1, Did2, converts ESCRT-III subunit Ist1 from an inhibitor to a stimulator of the enzyme (maximal stimulation at 0.008 or less mM). Mutants Ist1(L168A/Y172A) and Ist1(K135A) hyperstimulate enzyme ATPase activity
-
LIP5F388A
a weak SKD1 interactor, complements the lip5 mutant for heat and salt stress tolerance, most likely due to its overexpression driven by the strong CaMV 35S promoter in the transgenic plants
-
Lyst-interacting protein5
LIP5, interacts strongly with enzyme SKD1 and stimulates the ATPase activity of the enzyme by 4 to 5fold. LIP5 is a positive regulator of enzyme SKD1 in multivesicular bodies biogenesis and is a critical target of the mitogen-activated protein kinases MPK3 and MPK6 and plays an important role in the plant immune system. Disruption of LIP5 causes compromised tolerance to both heat and salt stresses. When compared with wild-type plants, lip5 mutants accumulate increased levels of ubiquitinated protein aggregates and NaCl under heat and salt stresses, respectively. LIP5 is regulated by phosphorylation, overview. Mutation of MPK phosphorylation sites in LIP5 does not affect its interaction with SKD1 but reduces its stability and, as a result, compromises its ability to complement the basal resistance of the lip5 mutants
-
p47
-
cofactor to ATPase p97
-
SNARE complex
-
SNARE-stimulated ATP hydrolysis, all four SNARE complexes similarly stimulate the steady-state rate of NSF-catalyzed ATP hydrolysis activity, suggesting that the stimulation of ATPase activity is independent of SNARE primary sequence variation and N-terminal domain architecture
-
Vps2p helix 5 peptide C
stimulates Vps4p ATPase activity and stabilizes the hexamer
-
Vta1p
-
additional information
-