3.6.1.8: ATP diphosphatase

This is an abbreviated version!
For detailed information about ATP diphosphatase, go to the full flat file.

Reaction

ATP
+
H2O
=
AMP
+
diphosphate

Synonyms

ATPase, ATPDase, ATP pyrophosphohydrolase, pyrophosphatase, adenosine triphosphate, adenosine triphosphate pyrophosphatase, ATP pyrophosphatase, ATPdiphosphohydrolase, Pk-rec, ATPDase 1

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.8 ATP diphosphatase

Inhibitors

Inhibitors on EC 3.6.1.8 - ATP diphosphatase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
15-desoxybludein
-
0.065 mg/ml, 11% inhibition
-
AMP
-
slight inhibition
Caffeine
-
25% inhibition at 3 mM
cAMP
-
20% inhibition at 3 mM
eremantolide C
-
0.065 mg/ml, 17% inhibition
glaucolide A
-
0.065 mg/ml, 11% inhibition
glaucolide B
-
0.065 mg/ml, 16% inhibition
GMP
-
competitive inhibition with Ki: 0.001 mM
goyazensolide
-
0.065 mg/ml, 10% inhibition
isogoyazensolide
-
0.065 mg/ml, 11% inhibition
licnofolide
-
0.065 mg/ml, 22% inhibition
licoflavone B
isolated from Glycyrrhiza inflata, possesses high in vitro schistosomicidal activity against adult worms of Schistosoma mansoni. Licoflavone B causes massive damage in the worm's tegument and inhibits egg laying, without affecting mammalian Vero cells. The tegument of Schistosoma mansoni is crucial for the parasite survival and its host immune defense. Licoflavone B is highly effective in inhibiting Schistosoma mansoni ATP diphosphohydrolase, docking studies with licoflavone B and SmATPase 1 revealing a spontaneous process. The docking study predicts different interactions between licoflavone B and ATPDase 1, corroborating with the in vitro inhibitory activity. Licoflavone B also shows inhibitory activity against ATPase in Schistosoma mansoni
phosphatidylserine
-
-
thapsigargicin
-
0.065 mg/ml, 57% inhibition
thapsigargin
-
inhibits ATP hydrolysis, 70% inhibition at 0.065 mg/ml, mixed type inhibition, little or not affected by changes in free Ca2+ or Mg2+ concentrations, hydrolysis of ADP is not inhibited
UDPGlc
-
very weak
additional information
-