3.6.1.8: ATP diphosphatase
This is an abbreviated version!
For detailed information about ATP diphosphatase, go to the full flat file.
Reaction
Synonyms
adenosine triphosphate pyrophosphatase, ATP pyrophosphatase, ATP pyrophosphohydrolase, ATPase, ATPDase, ATPDase 1, ATPdiphosphohydrolase, Pk-rec, pyrophosphatase, adenosine triphosphate
ECTree
3.6.1.8 ATP diphosphataseAdvanced search results
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Inhibitors on EC 3.6.1.8 - ATP diphosphatase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
licoflavone B
isolated from Glycyrrhiza inflata, possesses high in vitro schistosomicidal activity against adult worms of Schistosoma mansoni. Licoflavone B causes massive damage in the worm's tegument and inhibits egg laying, without affecting mammalian Vero cells. The tegument of Schistosoma mansoni is crucial for the parasite survival and its host immune defense. Licoflavone B is highly effective in inhibiting Schistosoma mansoni ATP diphosphohydrolase, docking studies with licoflavone B and SmATPase 1 revealing a spontaneous process. The docking study predicts different interactions between licoflavone B and ATPDase 1, corroborating with the in vitro inhibitory activity. Licoflavone B also shows inhibitory activity against ATPase in Schistosoma mansoni
thapsigargin
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inhibits ATP hydrolysis, 70% inhibition at 0.065 mg/ml, mixed type inhibition, little or not affected by changes in free Ca2+ or Mg2+ concentrations, hydrolysis of ADP is not inhibited
additional information
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no inhibition by 0.065 mg/ml 15-desoxygoyazensolide
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additional information
in vitro schistosomicidal activity of the crude extract of Glycyrrhiza inflata roots containing echinatin, licoflavone A and licoflavone B
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additional information
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in vitro schistosomicidal activity of the crude extract of Glycyrrhiza inflata roots containing echinatin, licoflavone A and licoflavone B
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