3.6.1.6: nucleoside diphosphate phosphatase

This is an abbreviated version!
For detailed information about nucleoside diphosphate phosphatase, go to the full flat file.

Word Map on EC 3.6.1.6

3.6.1.6

thiamine

apparatus

cytochemical

cisternae

microglial

cytochemistry

saccule

5'-nucleotidase

glucose-6-phosphatase

ectonucleotidases

purinergic

osmium

nadpase

monophosphatase

ramify

tetroxide

ectonucleoside

histoenzymatic

ultracytochemical

cmpase

postfix

dictyosome

g-6-pase

analysis

Reaction

Synonyms

adenosine diphosphatase, adenosinepyrophosphatase, ADPase, At3g04080, At5g18280, AtAPY1, AtAPY2, calcium activated nucleotidase 1, Cant1, CD39, CDPase, E-NTPDase1, ecto-apyrase, ecto-ATPase, ecto-nucleotidase, ectonucleoside triphosphate diphosphohydrolase, ER-UDPase, GDA1, GDPase, GDPase/UDPase, GS52, guanosine 5'-diphosphatase, guanosine diphosphatase, IDPase, inosine 5'-diphosphatase, inosine diphosphatase, lumenal ecto-nucleoside di-phosphohydrolase, lumenal NDPase, lumenal uridine diphosphatase, Lysosomal apyrase-like protein of 70 kDa, MIG-23, More, NDPase, NTPDase, NTPDase1, NTPDase1/CD39, NTPDase2, NTPDase3, NTPDase4, NTPDase5, NTPDase6, NTPDase6 (CD39L2) nucleotidase, NTPDase8, nucleoside 5'-diphosphatase, Nucleoside diphosphatase, nucleoside diphosphate phosphatase, nucleoside diphosphate phosphohydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate diphosphohydrolase-1, PAE2307, Proto-oncogene cph, SA1684, SA1684 protein, thiaminpyrophosphatase, TPPase, TTHA1091, type B nucleoside diphosphatase, type L nucleoside diphosphatase, UDA-1, UDPase

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.6 nucleoside diphosphate phosphatase

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Results	in table
7	Activating Compound
116	AA Sequence
1	Application
1	CAS Registry Number
10	Cloned(Commentary)
3	Crystallization (Commentary)
83	Disease/ Diagnostics
56	General Information
2	General Stability
2	IC50 Value
50	Inhibitors
11	kcat/KM [mM/s]
1	Ki Value [mM]
34	KM Value [mM]
37	Localization
48	Metals/Ions
20	Molecular Weight [Da]
53	Natural Substrates/ Products (Substrates)
330	Organism
1	Oxidation Stability
5	Pathway
6	PDB ID
28	pH Optimum
2	pH Range
3	pH Stability
3	Posttranslational Modification
23	Protein Variants
12	Purification (Commentary)
1	Reaction
1	Reaction Type
51	Reference
1	Renatured (Commentary)
90	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
165	Substrates and Products (Substrate)
14	Subunits
148	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
6	Temperature Stability [°C]
9	Turnover Number [1/s]

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Reference on EC 3.6.1.6 - nucleoside diphosphate phosphatase

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210202

Sano, S.; Matsuda, Y.; Nakagawa, H.

Type B nucleoside-diphosphatase of rat brain. Purification and properties of an enzyme with high thiamin pyrophosphatase activity

Eur. J. Biochem.

171

231-236

1988

Rattus norvegicus

2828050

210203

De Groot, H.; Noll, T.; Toelle, T.

Loss of latent activity of liver microsomal membrane enzymes evoked by lipid peroxidation. Studies of nucleoside diphosphatase, glucose-6-phosphatase, and UDP glucuronyltransferase

Biochim. Biophys. Acta

815

91-96

1985

Rattus norvegicus

2985117

210204

Sano, S.; Matsuda, Y.; Miyamoto, S.; Nakagawa, H.

Thiamine pyrophosphatase and nucleoside diphosphatase in rat brain

Biochem. Biophys. Res. Commun.

118

292-298

1984

Rattus norvegicus

6320828

210205

Ohkubo, I.; Taniguchi, N.; Mitsuyama, T.; Tsukada, Y.; Makita, A.

Comparative studies on nucleoside diphosphatase of rat ascites hepatoma and rat liver: activity level, purification and properties

Int. J. Biochem.

1075-1081

1982

Rattus norvegicus

6293897

210206

Yang, W.J.; Kim, K.W.; Lee, B.J.

Rat brain nucleoside diphosphatase: purification and properties of type L isoenzyme

Arch. Pharm. Res.

256-262

1994

Rattus norvegicus

210207

Brandan, E.; Fleischer, B.

Orientation and role of nucleosidediphosphatase and 5'-nucleotidase in Golgi vesicles from rat liver

Biochemistry

4640-4645

1982

Rattus norvegicus

6291586

210208

Ohkubo, I.; Ishibashi, T.; Taniguchi, N.; Makita, A.

Purification and characterization of nucleoside diphosphatase from rat-liver microsomes. Evidence for metalloenzyme and glycoprotein

Eur. J. Biochem.

112

111-118

1980

Rattus norvegicus

6256164

210209

Kawakita, N.; Yamazaki, M.

Immobilization of nucleoside diphosphatase at its allosteric site using immobilized derivatives of pyridoxal 5 -phosphate

Arch. Biochem. Biophys.

204

326-330

1980

Rattus norvegicus

6252848

210210

Finch, S.A.E.; Slater, T.F.; Stier, A.

Nucleotide metabolism by microsomal UDP-glucuronyltransferase and nucleoside diphosphatase as determined by 31P nuclear-magnetic resonance spectroscopy

Biochem. J.

177

925-930

1979

Oryctolagus cuniculus

220955

210211

Kawakita, N.; Yamazaki, M.

Allosteric properties of nucleoside diphosphatase. Activation by pyridoxal 5'-phosphate and specific modification of effector binding sites

Biochem. J.

3546-3551

1978

Rattus norvegicus

210795

210213

Ishibashi, T.; Gasa, S.; Ohkubo, I.; Makita, A.

Affinity purification and some properties of nucleoside diphosphatase from rat liver cytosol

Biochim. Biophys. Acta

525

265-274

1978

Rattus norvegicus

210813

210216

Shirasaka, T.; Arima, T.; Fujii, S.

Studies on mitochondrial and microsomal nucleoside diphosphatases of rat liver

J. Biochem.

99-106

1974

Rattus norvegicus

4373445

210217

Pinsley, C.L.; Scrutton, M.C.

Nucleoside diphosphatase from pig liver: purification and some properties

Arch. Biochem. Biophys.

158

331-345

1973

Sus scrofa

4354032

654678

Ivanenkov, V.V.; Murphy-Piedmonte, D.M.; Kirley, T.L.

Bacterial expression,characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function

Biochemistry

11726-11735

2003

Homo sapiens (O75354), Homo sapiens

14529283

656079

Failer, B.U.; Braun, N.; Zimmermann, H.

Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase

J. Biol. Chem.

277

36978-36986

2002

Rattus norvegicus (Q8K4Y7)

12167635

656961

Mikami, S.; Suganuma, R.; Hori, H.; Mitsui, T.

Purification and characterization of Golgi membrane-bound nucleoside diphosphatase from suspension-cultured cells of sycamore (Acer pseudoplatanus L.)

Plant Biotechnol.

259-265

2001

Acer pseudoplatanus

669238

Uccelletti, D.; OCallaghan, C.; Berninsone, P.; Zemtseva, I.; Abeijon, C.; Hirschberg, C.B.

ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans

J. Biol. Chem.

279

27390-27398

2004

Caenorhabditis elegans

15102851

670350

Nishiwaki, K.; Kubota, Y.; Chigira, Y.; Roy, S.K.; Suzuki, M.; Schvarzstein, M.; Jigami, Y.; Hisamoto, N.; Matsumoto, K.

An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans

Nat. Cell Biol.

31-37

2004

Caenorhabditis elegans

14688791

698165

Martin-Satue, M.; Lavoie, E.G.; Pelletier, J.; Fausther, M.; Csizmadia, E.; Guckelberger, O.; Robson, S.C.; Sevigny, J.

Localization of plasma membrane bound NTPDases in the murine reproductive tract

Histochem. Cell Biol.

131

615-628

2009

Mus musculus, Mus musculus C57BL/6, Rattus norvegicus

19125273

711898

Levesque, S.A.; Kukulski, F.; Enjyoji, K.; Robson, S.C.; Sevigny, J.

NTPDase1 governs P2X7-dependent functions in murine macrophages

Eur. J. Immunol.

1473-1485

2010

Mus musculus

20201036

718541

Lavoie, E.G.; Gulbransen, B.D.; Martin-Satue, M.; Aliagas, E.; Sharkey, K.A.; Sevigny, J.

Ectonucleotidases in the digestive system: focus on NTPDase3 localization

Am. J. Physiol. Gastrointest. Liver Physiol.

300

G608-G620

2011

Mus musculus, Mus musculus C57BL/6

21233276

718543

Fausther, M.; Lecka, J.; Soliman, E.; Kauffenstein, G.; Pelletier, J.; Sheung, N.; Dranoff, J.; Sevigny, J.

Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver

Am. J. Physiol. Gastrointest. Liver Physiol.

302

447-459

2012

Rattus norvegicus (P97687), Rattus norvegicus (Q5DRK1), Rattus norvegicus Sprague-Dawley (P97687), Rattus norvegicus Sprague-Dawley (Q5DRK1)

22135310

719196

Kauffenstein, G.; Fuerstenau, C.R.; DOrleans-Juste, P.; Sevigny, J.

The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation

Br. J. Pharmacol.

159

576-585

2010

Mus musculus, Mus musculus 129 SVJ x C57 BL/6

20067476

720736

Tanaka, K.; Nguyen, C.T.; Libault, M.; Cheng, J.; Stacey, G.

Enzymatic activity of the soybean ecto-apyrase GS52 is essential for stimulation of nodulation

Plant Physiol.

155

1988-1998

2011

Glycine max

21346172

733220

Lopez-Esparza, A.; Alvarez-Vargas, A.; Mora-Montes, H.M.; Hernandez-Cervantes, A.; Del Carmen Cano-Canchola, M.; Flores-Carreon, A.

Isolation of Sporothrix schenckii GDA1 and functional characterization of the encoded guanosine diphosphatase activity

Arch. Microbiol.

195

499-506

2013

Sporothrix schenckii, Sporothrix schenckii EH-206

23715619

733655

Krug, U.; Totzauer, R.; Zebisch, M.; Straeter, N.

The ATP/ADP substrate specificity switch between Toxoplasma gondii NTPDase1 and NTPDase3 is caused by an altered mode of binding of the substrate base

ChemBioChem

2292-2300

2013

Toxoplasma gondii (Q27895)

24115522

751452

Paganini, C.; Monti, L.; Costantini, R.; Besio, R.; Lecci, S.; Biggiogera, M.; Tian, K.; Schwartz, J.M.; Huber, C.; Cormier-Daire, V.; Gibson, B.G.; Pirog, K.A.; Forlino, A.; Rossi, A.

Calcium activated nucleotidase 1 (CANT1) is critical for glycosaminoglycan biosynthesis in cartilage and endochondral ossification

Matrix Biol.

70-90

2018

Mus musculus (Q8VCF1)

30439444

755996

Chiu, T.Y.; Lao, J.; Manalansan, B.; Loque, D.; Roux, S.J.; Heazlewood, J.L.

Biochemical characterization of Arabidopsis APYRASE family reveals their roles in regulating endomembrane NDP/NMP homoeostasis

Biochem. J.

472

43-54

2015

Arabidopsis thaliana (Q9SPM5), Arabidopsis thaliana (Q9SQG2)

26338998

756218

Tomoike, F.; Tsunetou, A.; Kim, K.; Nakagawa, N.; Kuramitsu, S.; Masui, R.

A putative adenosine kinase family protein possesses adenosine diphosphatase activity

Biosci. Biotechnol. Biochem.

2138-2143

2016

Thermus thermophilus (Q5SJC3), Pyrobaculum aerophilum (Q8ZVF7), Pyrobaculum aerophilum DSM 7523 (Q8ZVF7), Pyrobaculum aerophilum IM2 (Q8ZVF7), Thermus thermophilus DSM 579 (Q5SJC3), Pyrobaculum aerophilum NBRC 100827 (Q8ZVF7), Pyrobaculum aerophilum ATCC 51768 (Q8ZVF7), Pyrobaculum aerophilum JCM 9630 (Q8ZVF7), Thermus thermophilus ATCC 27634 (Q5SJC3)

27484886

756751

Delgado-Carmona, J.D.; Ramirez-Quijas, M.D.; Vega-Gonzalez, A.; Lopez-Romero, E.; Cuellar-Cruz, M.

Changes in GDPase/UDPase enzymatic activity in response to oxidative stress in four Candida species

Folia Microbiol. (Praha)

343-350

2015

Candida albicans, Candida parapsilosis, Pichia kudriavzevii, [Candida] glabrata

25762354

757160

Imae, K.; Saito, Y.; Kizaki, H.; Ryuno, H.; Mao, H.; Miyashita, A.; Suzuki, Y.; Sekimizu, K.; Kaito, C.

Novel nucleoside diphosphatase contributes to Staphylococcus aureus virulence

J. Biol. Chem.

291

18608-18619

2016

Staphylococcus aureus (Q7A4T2), Staphylococcus aureus, Staphylococcus aureus N315 (Q7A4T2)

27422825