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3.6.1.6: nucleoside diphosphate phosphatase

This is an abbreviated version!
For detailed information about nucleoside diphosphate phosphatase, go to the full flat file.

Word Map on EC 3.6.1.6

Reaction

a nucleoside diphosphate
+
H2O
=
a nucleoside phosphate
+
phosphate

Synonyms

adenosine diphosphatase, adenosinepyrophosphatase, ADPase, At3g04080, At5g18280, AtAPY1, AtAPY2, calcium activated nucleotidase 1, Cant1, CD39, CDPase, E-NTPDase1, ecto-apyrase, ecto-ATPase, ecto-nucleotidase, ectonucleoside triphosphate diphosphohydrolase, ER-UDPase, GDA1, GDPase, GDPase/UDPase, GS52, guanosine 5'-diphosphatase, guanosine diphosphatase, IDPase, inosine 5'-diphosphatase, inosine diphosphatase, lumenal ecto-nucleoside di-phosphohydrolase, lumenal NDPase, lumenal uridine diphosphatase, Lysosomal apyrase-like protein of 70 kDa, MIG-23, More, NDPase, NTPDase, NTPDase1, NTPDase1/CD39, NTPDase2, NTPDase3, NTPDase4, NTPDase5, NTPDase6, NTPDase6 (CD39L2) nucleotidase, NTPDase8, nucleoside 5'-diphosphatase, Nucleoside diphosphatase, nucleoside diphosphate phosphatase, nucleoside diphosphate phosphohydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate diphosphohydrolase-1, PAE2307, Proto-oncogene cph, SA1684, SA1684 protein, thiaminpyrophosphatase, TPPase, TTHA1091, type B nucleoside diphosphatase, type L nucleoside diphosphatase, UDA-1, UDPase

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.6 nucleoside diphosphate phosphatase

Engineering

Engineering on EC 3.6.1.6 - nucleoside diphosphate phosphatase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D209A
-
site-directed mutagenesis, the mutant enzyme shows reduced activity compared to the wild-type enzyme
E182A
-
site-directed mutagenesis, the mutant enzyme shows reduced activity compared to the wild-type enzyme
Q216A
-
site-directed mutagenesis, the mutant enzyme shows reduced activity compared to the wild-type enzyme
S214A
-
site-directed mutagenesis, the mutant enzyme shows reduced activity compared to the wild-type enzyme
C139S
mutant enzyme lacking the single free sulfhydryl is more stable than the wild-type enzyme under refolding conditions, 10-15°C, 2-3 days. The mutant enzyme is less susceptible to oxidative inactivation than the wild-type enzyme
R302H
inactive
D106A
site-directed mutagenesis, the mutant shows highly reduced nucleoside diphosphatase activity
D123A/E124A
site-directed mutagenesis, the mutant shows highly reduced nucleoside diphosphatase activity
Y88A
site-directed mutagenesis, the mutant shows highly reduced nucleoside diphosphatase activity
D106A
-
site-directed mutagenesis, the mutant shows highly reduced nucleoside diphosphatase activity
-
D123A/E124A
-
site-directed mutagenesis, the mutant shows highly reduced nucleoside diphosphatase activity
-
Y88A
-
site-directed mutagenesis, the mutant shows highly reduced nucleoside diphosphatase activity
-
E493G
the mutant of isoform NTPDase1 shows conversion of ATP/ADP specificity compared to the wild type enzyme
R492G
the mutant of isoform NTPDase1 shows conversion of ATP/ADP specificity compared to the wild type enzyme
R492G/E493G
the mutant of isoform NTPDase1 shows conversion of ATP/ADP specificity compared to the wild type enzyme
additional information