3.6.1.42: guanosine-diphosphatase
This is an abbreviated version!
For detailed information about guanosine-diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.42
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3.6.1.42
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charcot-marie-tooth
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neuropathy
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demyelinate
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nerve
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ganglioside-induced
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purinergic
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differentiation-associated
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ectonucleotidases
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gdpase
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apyrase
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ecto-5\'-nucleotidase
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sural
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ectonucleoside
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ntpdase3
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sh3tc2
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ecto-enzymes
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ecto-adenosine
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3.6.1.5
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ecto-ntpdase
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charcot
- 3.6.1.42
- charcot-marie-tooth
- neuropathy
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demyelinate
- nerve
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ganglioside-induced
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purinergic
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differentiation-associated
- ectonucleotidases
- gdpase
- apyrase
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ecto-5\'-nucleotidase
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sural
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ectonucleoside
- ntpdase3
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sh3tc2
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ecto-enzymes
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ecto-adenosine
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3.6.1.5
- ecto-ntpdase
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charcot
Reaction
Synonyms
APY1, DIPP1, E-NTPDase, ecto-nucleoside triphosphate diphosphohydrolase, gda1p (GDA1 gene product), Gdap1, Gdp1p, GDPase, guanosine diphosphatase, KlGdap1, phosphatase, guanosine di-, UDPase
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Natural Substrates Products
Natural Substrates Products on EC 3.6.1.42 - guanosine-diphosphatase
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REACTION DIAGRAM
UDP + H2O
UMP + phosphate
the enzyme's UDPase activity plays a role in uridine nucleotide sugar transport into Golgi vesicles
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5'-GMP + phosphate
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possible biological function in maintaining the cellular pool of GTP-GDP
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?
GDP + H2O
5'-GMP + phosphate
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GTP is an important steric effector in many biological systems, GDP a potent inhibitor: GDPase activity could be involved in preventing potential inhibitory levels of GDP from accumulating
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?
GDP + H2O
5'-GMP + phosphate
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cleaves GDP that originates from GDP-mannose after mannosylation of glycoproteins in Golgi complex
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?
GDP + H2O
5'-GMP + phosphate
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GDP is a reaction product following outer-chain mannosylation of luminal proteins and inhibitor of mannosyltransferases. It is hypothesized that GMP then returns to the cytosol. GDPase presumably serves as an essential function in processing of yeast glycoproteins
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GDP + H2O
5'-GMP + phosphate
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GDPase plays a role in O- and N-mannosylation of proteins such as chitinase and carboxypeptidase Y and glycosylation of external invertase and of mannosylation of inositolphosphorylceramides
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?
GDP + H2O
5'-GMP + phosphate
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GDP is known to be an inhibitor of mannosylation reactions in the Golgi lumen, removal of GDP by conversion to GMP, the latter not being an inhibitor of these reactions, would allow mannosylation to proceed
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GDP + H2O
5'-GMP + phosphate
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guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen
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?
GDP + H2O
GMP + phosphate
GDP hydrolysis occurs in the Golgi lumen to give GMP, which is required as antiporter for GDP-mannose transport into the Golgi lumen
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GDP + H2O
GMP + phosphate
the enzyme's GDPase activity plays a role in guanosine nucleotide sugar transport into Golgi vesicles
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GDP + H2O
GMP + phosphate
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the enzyme has a main role in protein glycosylation, enzyme deficiency leads to N-glycosylation defects of invertase
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physiological function, role in O- and N-glycosylation, and cell and hyphae morphogenesis, affects the cell surface charge and phosphate content, enzyme is not required for the adhesion of Candida albicans to epithelial cells, overview
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additional information
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physiological function, GMP and UMP are required as antiporters for guanosine and uridine nucleotide sugar transport into the Golgi lumen, involved in O-glycosylation
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additional information
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physiological function, GMP and UMP are required as antiporters for guanosine and uridine nucleotide sugar transport into the Golgi lumen, involved in O-glycosylation
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additional information
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guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen
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additional information
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GDPase is required to complete O-glycosylation of proteins
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additional information
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GDPase not essential for cell viability and growth
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additional information
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GDPase plays a role in O- and N-mannosylation of proteins such as chitinase and carboxypeptidase Y and glycosylation of external invertase and of mannosylation of inositolphosphorylceramides and in synthesis of cell wall
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additional information
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GDPase plays an important role in mannosylation of proteins and lipids by regulating the amount of GDP-mannose available in Golgi lumen
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additional information
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GDPase plays an important role in mannosylation of proteins and lipids by regulating the amount of GDP-mannose available in Golgi lumen
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additional information
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GDPase plays an important role in mannosylation of proteins and lipids by regulating the amount of GDP-mannose available in Golgi lumen
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additional information
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necessary for Golgi-specific glycosylation reactions
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additional information
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GDPase has an important role in glycosylation reactions in Golgi lumen
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additional information
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GDPase has an important role in glycosylation reactions in Golgi lumen
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additional information
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GDPase has an important role in glycosylation reactions in Golgi lumen
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